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IMMU-33. CCL4 DRIVES GLIOBLASTOMA (GBM) TUMOR MICROENVIRONMENT (TME) REPROGRAMMING AFTER TREATMENT WITH A NOVEL MRNA VACCINE

Autor: Farhad Dastmalchi, Nagheme Thomas, Matt Frain, Ghaidaa Ebrahim, Ginger Moore, Macaulay Tomdio, Hector Mendez-Gomez, Elias Sayour, Vignesh Subramaniam, Thomas Angelini, Duane Mitchell, Maryam Rahman

Publikováno v: Neuro-Oncology. 24:vii138-vii138

INTRODUCTION Our group has developed a patented vaccine platform that combines an mRNA-nanoparticle with CXCL9 loaded polyethylene glycol (PEG) hydrogel. The HCM vaccine is given SQ and recruits a diverse immune cell population to deliver a large pay

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::947120a22fbc85e9670751633ad4082d
https://doi.org/10.1093/neuonc/noac209.530

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DDDR-29. THE HYDROGEL-CXCL9-MRNA (HCM) VACCINE RESULTS IN SIGNIFICANT ANTI-TUMOR EFFICACY THROUGH RECRUITMENT OF NATURAL KILLER (NK) CELLS

Autor: Farhad Dastmalchi, Nagheme Thomas, Ghaidaa Ebrahim, Matt Frain, Ginger Moore, Hector Mendez-Gomez, Elias Sayour, Macaulay Tomdio, Vignesh Subramaniam, Thomas Angelini, Duane Mitchell, Maryam Rahman

Publikováno v: Neuro-Oncology. 24:vii105-vii105

INTRODUCTION: Immunotherapy for GBM has resulted in limited benefits to overall survival due to the targeting of limited antigens and the hostile TME. Our group has developed a patented vaccine platform that combines an mRNA-nanoparticle with CXCL9 l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25bd1bd44589edaad510a2338b8a5dbb
https://doi.org/10.1093/neuonc/noac209.394

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