Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Matt E. Oates"'
Autor:
Chang Lu, Jan Zaucha, Rihab Gam, Hai Fang, Ben Smithers, Matt E. Oates, Miguel Bernabe-Rubio, James Williams, Natalie Zelenka, Arun Prasad Pandurangan, Himani Tandon, Hashem Shihab, Raju Kalaivani, Minkyung Sung, Adam J. Sardar, Bastian Greshake Tzovoras, Davide Danovi, Julian Gough
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Systematically predicting phenotypes or disease risks based on the information of an individual’s genetic variation remains an unsolved challenge. Here, the authors develop a knowledge-based approach for performing and evaluating hypothesis-free ph
Externí odkaz:
https://doaj.org/article/fe21f256cb6b4004bd97bf5b493f46e6
Publikováno v:
Pandurangan, A P, Stahlhacke, J, Oates, M E, Smithers, B & Gough, J 2019, ' The SUPERFAMILY 2.0 database : a significant proteome update and a new webserver ', Nucleic Acids Research, vol. 47, no. D1, pp. D490-D494 . https://doi.org/10.1093/nar/gky1130
Nucleic Acids Research
Nucleic Acids Research
Here, we present a major update to the SUPERFAMILY database and the webserver. We describe the addition of new SUPERFAMILY 2.0 profile HMM library containing a total of 27 623 HMMs. The database now includes Superfamily domain annotations for million
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9457cd654a4a005bf2ce9703529c957
https://doi.org/10.1093/nar/gky1130
https://doi.org/10.1093/nar/gky1130
Autor:
Matt E. Oates, Richard Connor, Ravi V. Mural, Lirong Zeng, Bangjun Zhou, Julian Gough, Xuanyang Chen, Gregory B. Martin
Publikováno v:
Plant Physiology. 173:1371-1390
Of the three classes of enzymes involved in ubiquitination, ubiquitin-conjugating enzymes (E2) have been often incorrectly considered to play merely an auxiliary role in the process, and few E2 enzymes have been investigated in plants. To reveal the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa13115a0ce3d71b1f1a3eae4eb395c
https://doi.org/10.1104/pp.16.01190
https://doi.org/10.1104/pp.16.01190
Publikováno v:
Smithers, B, Oates, M & Gough, J 2019, ' 'Why genes in pieces?'-revisited ', Nucleic Acids Research, vol. 47, no. 10, pp. 4970-4973 . https://doi.org/10.1093/nar/gkz284
Nucleic Acids Research
Nucleic Acids Research
The alignment between the boundaries of protein domains and the boundaries of exons could provide evidence for the evolution of proteins via domain shuffling, but literature in the field has so far struggled to conclusively show this. Here, on larger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ed1b6e241fbd99984e1acb05897ecb
https://research-information.bris.ac.uk/en/publications/c57db84b-882e-486b-9381-79a887fa931d
https://research-information.bris.ac.uk/en/publications/c57db84b-882e-486b-9381-79a887fa931d
Publikováno v:
Protein Science. 25:1030-1036
We have identified that the collagen helix has the potential to be disruptive to analyses of intrinsically disordered proteins. The collagen helix is an extended fibrous structure that is both promiscuous and repetitive. Whilst its sequence is predic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa606d13b5ce43fdce7a0d470a0c7b2d
https://doi.org/10.1002/pro.2913
https://doi.org/10.1002/pro.2913
Autor:
Matt E. Oates, Harukazu Suzuki, Christian M. Nefzger, Owen J. L. Rackham, Jose M. Polo, Alistair R. R. Forrest, Carsten O. Daub, Enrico Petretto, Yoshihide Hayashizaki, Jaber Firas, Jay W. Shin, Hai Fang, Julian Gough, Anja S Knaupp, Melissa L. Holmes
Publikováno v:
Rackham, O J L, Firas, J, Fang, H, Oates, M E, Holmes, M L, Knaupp, A S, Suzuki, H, Nefzger, C M, Daub, C O, Shin, J W, Petretto, E, Forrest, A R R, Hayashizaki, Y & Polo, J M & Gough, J 2016, ' A predictive computational framework for direct reprogramming between human cell types ', Nature Genetics, vol. 48, no. 3, pp. 331-335 . https://doi.org/10.1038/ng.3487
Transdifferentiation, the process of converting from one cell type to another without going through a pluripotent state, has great promise for regenerative medicine. The identification of key transcription factors for reprogramming is currently limit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a441d839ee3859233a23cecc47bc9649
https://doi.org/10.1038/ng.3487
https://doi.org/10.1038/ng.3487
Autor:
Tilman Flock, Robert J. Weatheritt, Julian Gough, Natasha S. Latysheva, Marija Buljan, Louis Maddox, M. Madan Babu, Matt E. Oates
Publikováno v:
Molecular Cell
Latysheva, NS, Oates, ME, Maddox, L, Flock, T, Gough, J, Buljan, M, Weatheritt, RJ & Babu, M M 2016, ' Molecular Principles of Gene Fusion Mediated Rewiring of Protein Interaction Networks in Cancer ', Molecular Cell, vol. 63, no. 4, pp. 579-592 . https://doi.org/10.1016/j.molcel.2016.07.008
Latysheva, NS, Oates, ME, Maddox, L, Flock, T, Gough, J, Buljan, M, Weatheritt, RJ & Babu, M M 2016, ' Molecular Principles of Gene Fusion Mediated Rewiring of Protein Interaction Networks in Cancer ', Molecular Cell, vol. 63, no. 4, pp. 579-592 . https://doi.org/10.1016/j.molcel.2016.07.008
Summary Gene fusions are common cancer-causing mutations, but the molecular principles by which fusion protein products affect interaction networks and cause disease are not well understood. Here, we perform an integrative analysis of the structural,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0e74426004e7e1a79ac7b7552748bc2
http://europepmc.org/articles/PMC5003813
http://europepmc.org/articles/PMC5003813
Autor:
Maxim Scheremetjew, Catherine Rivoire, Matt E. Oates, Ioannis Xenarios, Matthew Fraser, Daniel Kahn, Teresa K. Attwood, Dominique Guyot, Conor McMenamin, Daniel H. Haft, Craig McAnulla, Amaia Sangrador-Vegas, Robert D. Finn, Gift Nuka, Claudia Rato, Siew-Yit Yong, Julian Gough, Louise C. Daugherty, Alex Bateman, Cathy H. Wu, Christian J. A. Sigrist, Christine A. Orengo, Ian Sillitoe, Nicole Redaschi, Ivica Letunic, Hsin-Yu Chang, Paul Thomas, Rodrigo Lopez, Sarah Hunter, Darren A. Natale, Marco Punta, Alex L. Mitchell, Hongzhan Huang, Huaiyu Mi, Sebastien Pesseat, Peer Bork
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2015, 43 (D1), pp.D213-D221. ⟨10.1093/nar/gku1243⟩
Nucleic Acids Research, 2015, 43 (D1), pp.D213-D221. ⟨10.1093/nar/gku1243⟩
Nucleic Acids Research, vol. 43, no. Database issue, pp. D213-D221
Nucleic Acids Research D1 (43), D213-D221. (2015)
Europe PubMed Central
Nucleic Acids Research, Oxford University Press, 2015, 43 (D1), pp.D213-D221. ⟨10.1093/nar/gku1243⟩
Nucleic Acids Research, 2015, 43 (D1), pp.D213-D221. ⟨10.1093/nar/gku1243⟩
Nucleic Acids Research, vol. 43, no. Database issue, pp. D213-D221
Nucleic Acids Research D1 (43), D213-D221. (2015)
Europe PubMed Central
The InterPro database (http://www.ebi.ac.uk/interpro/) is a freely available resource that can be used to classify sequences into protein families and to predict the presence of important domains and sites. Central to the InterPro database are predic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6fe6fa011989500816ffe5fee26d23c
http://doc.rero.ch/record/295272/files/gku1243.pdf
http://doc.rero.ch/record/295272/files/gku1243.pdf
Autor:
Daniel Estévez Prado, AJ Venkatakrishnan, M. Madan Babu, Julian Gough, Matt E. Oates, Tilman Flock
Publikováno v:
Current Opinion in Structural Biology. 27:129-137
The seven-transmembrane (7TM) helix fold of G-protein coupled receptors (GPCRs) has been adapted for a wide variety of physiologically important signaling functions. Here, we discuss the diversity in the structured and disordered regions of GPCRs bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8854d26d839fa04bb6597deccf9dc8
https://doi.org/10.1016/j.sbi.2014.08.002
https://doi.org/10.1016/j.sbi.2014.08.002
Autor:
Matt E. Oates, Philip C. J. Donoghue, Julian Gough, Hai Fang, Alistair M. Hetherington, Elodie Marchadier
Publikováno v:
Marchadier, E S G, Oates, M, Fang, H, Donoghue, P, Hetherington, A & Gough, J 2016, ' Evolution of the calcium-based intracellular signalling system ', Genome Biology and Evolution, vol. 8, no. 7, pp. 2118-2132 . https://doi.org/10.1093/gbe/evw139
Genome Biology and Evolution
Genome Biology and Evolution, Society for Molecular Biology and Evolution, 2016, 8 (7), pp.2118-2132. ⟨10.1093/gbe/evw139⟩
Genome Biology and Evolution 7 (8), 2118-2132. (2016)
Genome Biology and Evolution
Genome Biology and Evolution, Society for Molecular Biology and Evolution, 2016, 8 (7), pp.2118-2132. ⟨10.1093/gbe/evw139⟩
Genome Biology and Evolution 7 (8), 2118-2132. (2016)
International audience; To progress our understanding of molecular evolution from a collection of well-studied genes toward the level of the cell, we must consider whole systems. Here, we reveal the evolution of an important intracellular signaling s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a556e7aa714b8a7b7068b0b777648601
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid: