Výsledky vyhledávání - "Matt D. Medlin"

Blocking Ligand Occupancy of the αVβ3 Integrin Inhibits the Development of Nephropathy in Diabetic Pigs

Autor: Dwight A. Bellinger, W. L. Flowers, Matt D. Medlin, K. Gollahon, Walker H. Busby, Kara R Stewart, Paul Dunbar, Amit Patel, Stefani Garbacik, Timothy C. Nichols, David R. Clemmons, Laura A. Maile, Nikol Garbacik

Publikováno v: Endocrinology. 155:4665-4675

Hyperglycemia stimulates secretion of αVβ3 ligands from vascular cells, including endothelial cells, resulting in activation of the αVβ3 integrin. This study determined whether blocking ligand occupancy of αVβ3 would inhibit the development of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c225b03e9d23b34f957c64b0e56129
https://doi.org/10.1210/en.2014-1318

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Nuclear RhoA signaling regulates MRTF-dependent SMC-specific transcription

Autor: Lee E. Mangiante, Kevin D. Mangum, Laura Weise-Cross, Joan M. Taylor, Dean P. Staus, Christopher P. Mack, Matt D. Medlin

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 307:H379-H390

We have previously shown that RhoA-mediated actin polymerization stimulates smooth muscle cell (SMC)-specific transcription by regulating the nuclear localization of the myocardin-related transcription factors (MRTFs). On the basis of the recent demo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e60b97553353b863a7f2383fc50f6a
https://doi.org/10.1152/ajpheart.01002.2013

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Formin Homology Domain–Containing Protein 1 Regulates Smooth Muscle Cell Phenotype

Autor: Dean P. Staus, Alicia L. Blaker, Joan M. Taylor, Christopher P. Mack, Matt D. Medlin

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 31:360-367

Objective— Our goal was to test whether formin homology protein 1 (FHOD1) plays a significant role in the regulation of smooth muscle cell (SMC) differentiation and, if so, whether Rho kinase (ROCK)–dependent phosphorylation in the diaphanous aut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d81f170e2fda367f64926aa17d26787
https://doi.org/10.1161/atvbaha.110.212993

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Sphingosine 1-Phosphate Receptor 2 Signals Through Leukemia-Associated RhoGEF (LARG), to Promote Smooth Muscle Cell Differentiation

Autor: Joan M. Taylor, Adi D. Dubash, Dean P. Staus, Christopher P. Mack, Matt D. Medlin

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 30:1779-1786

Objective— The goals of this study were to identify the signaling pathway by which sphingosine 1-phosphate (S1P) activates RhoA in smooth muscle cells (SMC) and to evaluate the contribution of this pathway to the regulation of SMC phenotype. Method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9effe0d4d77603eae54f2201c78230d4
https://doi.org/10.1161/atvbaha.110.209395

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Quantifying Sphingosine-1-Phosphate-Dependent Activation of the RhoGTPases

Autor: Joan M. Taylor, Christopher P. Mack, Matt D. Medlin

Publikováno v: Methods in Molecular Biology ISBN: 9781617797996

The GPCR-coupled sphingosine-1-phosphate (S1P) receptors regulate a number of important cell -functions, including proliferation, migration, and adhesion. Since these processes require dynamic regulation of the actin cytoskeleton, the ability to moni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ebb84d9dfa5e6f2a592af47a44fc1d
https://doi.org/10.1007/978-1-61779-800-9_8

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