Výsledky vyhledávání - "Matt A. Peterson"

An efficient one-pot synthesis of 2-aminobenzothiazoles from substituted anilines using benzyltrimethylammonium dichloroiodate and ammonium thiocyanate in DMSO:H2O

Autor: Reuben Dass, Matt A. Peterson

Publikováno v: Tetrahedron Letters. 83:153388

Treatment of a variety of substituted anilines with benzyltrimethylammonium dichloroiodate (1.2 equiv) and ammonium thiocyanate (1.0 equiv) in DMSO:H2O (9:1) at 70 °C gave the corresponding 2-aminobenzothiazoles in excellent isolated yields (75–97

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::980ef01eaefee53fb435bf3f3aaa3ded
https://doi.org/10.1016/j.tetlet.2021.153388

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An efficient microwave assisted synthesis of N′-aryl/(alkyl)-substituted N-(4-hydroxy-6-phenylpyrimidin-2-yl)guanidines: Scope and limitations

Autor: Paulo A. Machicao, Matt A. Peterson, Scott R. Burt, Nathan B. Lohner, J.D. Singleton, Ryan K. Christensen

Publikováno v: Tetrahedron Letters. 58:2318-2321

Treatment of N-[(4-hydroxy-6-phenyl)pyrimidin-2-yl]cyanamide with 1° alkyl or arylamines in isopropyl alcohol for only 10 min at 110–120 °C under microwave conditions gave the corresponding N′-alkyl(aryl)guanidine derivatives in excellent yield

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ede72c5d72c664a4bad954a01bd4ce72
https://doi.org/10.1016/j.tetlet.2017.03.063

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Synthesis and biological evaluation of novel pyrazolo[1,5-a]pyrimidines: Discovery of a selective inhibitor of JAK1 JH2 pseudokinase and VPS34

Autor: Rachel Smith, Reuben Dass, Matt A. Peterson, Nathaniel R. Neubert, Zak R. Webber, Justin D. Singleton, Marc D.H. Hansen

Publikováno v: Bioorganicmedicinal chemistry letters. 30(2)

A series of novel 3,6-di-substituted or 3-substituted pyrazolo[1,5-a]pyrimidines were prepared via a microwave-assisted approach that generated a broad array of derivatives in good yields (20–93%, ave. = 59%). The straightforward synthesis involved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c49c48014fdddeffb96dd3448a3626a
https://pubmed.ncbi.nlm.nih.gov/31831383

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Efficient synthesis of 5′-O(N)-carbamyl and -polycarbamyl nucleosides

Autor: Matt A. Peterson, Jadd R. Shelton

Publikováno v: Tetrahedron Letters. 54:6882-6885

A simple and efficient method for the preparation of 5′-O(N)-carbamyl and 5′-O(N)-polycarbamyl nucleoside derivatives is reported. The method consisted of treatment of 2′,3′-O-protected purine (Ado, Ino) or pyrimidine nucleosides (Thd, Urd) w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::435c7b1dcd0a54ef18263f5aca5b9d5b
https://doi.org/10.1016/j.tetlet.2013.10.029

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An efficient one-pot conversion of Boc-protected adenines to N6-ureas

Autor: Dominique Schols, Paulo A. Machicao, Matt A. Peterson

Publikováno v: Tetrahedron Letters. 56:6574-6576

Treatment of Boc-protected N 9 -aryladenines with 1° alkylamines (1.1 equiv) and DMAP (1.1 equiv) in DMF at 80 °C in the presence of activated 5 A molecular sieves gave the corresponding N 6 -urea derivatives in excellent yields (66–96%). Select

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ca3159c3da3a5ab12695084a822b1e9
https://doi.org/10.1016/j.tetlet.2015.10.021

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ChemInform Abstract: An Efficient One-Pot Conversion of Boc-Protected Adenines to N6-Ureas

Autor: Dominique Schols, Matt A. Peterson, Paulo A. Machicao

Publikováno v: ChemInform. 47

The reaction products are screened for antiproliferative activity against a panel consisting of L1210, CEM, and HeLa cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb11e773748d0d8810adcbb6c7bc1fcf
https://doi.org/10.1002/chin.201612072

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Synthesis and SAR of 2′,3′-bis-O-substituted N6, 5′-bis-ureidoadenosine derivatives: Implications for prodrug delivery and mechanism of action

Autor: Christopher E. Cutler, Jadd R. Shelton, Matt A. Peterson, Jan Balzarini, Megan S. Browning

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 22:6067-6071

A series of 2',3'-bis-O-silylated or -acylated derivatives of lead compound 3a (2',3'-bis-O-tert-butyldimethylsilyl-5'-deoxy-5'-(N-methylcarbamoyl)amino-N(6)-(N-phenylcarbamoyl)adenosine) were prepared and evaluated for antiproliferative activity aga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34287fd4034027ead3ecb9a6c8bef5d2
https://doi.org/10.1016/j.bmcl.2012.08.050

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Synthesis, SAR, and preliminary mechanistic evaluation of novel antiproliferative N6,5′-bis-ureido- and 5′-carbamoyl-N6-ureidoadenosine derivatives

Autor: Jan Balzarini, Christopher E. Cutler, Marcelio Oliveira, Jadd R. Shelton, Matt A. Peterson

Publikováno v: Bioorganic & Medicinal Chemistry. 20:1008-1019

We have developed efficient methods for the preparation of N(6),5'-bis-ureidoadenosine derivatives and their 5'-carbamoyl-N(6)-ureido congeners. Treatment of 5'-azido-5'-deoxy-N(6)-(N-alkyl or -arylurea)adenosine derivatives (6a-d) with H(2)/Pd-C or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2348f2f2a8089f0a90f4314efda2b672
https://doi.org/10.1016/j.bmc.2011.11.043

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