Zobrazeno 1 - 10
of 297
pro vyhledávání: '"Matt van de Rijn"'
Autor:
Thomas Yang Sun, MD, MHS, Brandon Nguyen, BA, Simon B. Chen, MD, Yasodha Natkunam, MD, PhD, Sukhmani Padda, MD, Matt van de Rijn, MD, Robert West, MD, PhD, Joel W. Neal, MD, PhD, Heather Wakelee, MD, Jonathan W. Riess, MD, MS
Publikováno v:
JTO Clinical and Research Reports, Vol 4, Iss 4, Pp 100498- (2023)
Introduction: CD47 is a tumor antigen that inhibits phagocytosis leading to immune evasion. Anti-CD47 therapy is a promising new immunotherapy across numerous tumor types, but it has not been tested in thymic epithelial tumors (TETs): thymomas and th
Externí odkaz:
https://doaj.org/article/30e41af60d4241beac6dc7f512ddccc4
Autor:
Myung Chang Lee, Hongchen Cai, Christopher W. Murray, Chuan Li, Yan Ting Shue, Laura Andrejka, Andy L. He, Alessandra M.E. Holzem, Alexandros P. Drainas, Julie H. Ko, Garry L. Coles, Christina Kong, Shirley Zhu, ChunFang Zhu, Jason Wang, Matt van de Rijn, Dmitri A. Petrov, Monte M. Winslow, Julien Sage
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111990- (2023)
Summary: Small cell lung cancer (SCLC) is a lethal form of lung cancer. Here, we develop a quantitative multiplexed approach on the basis of lentiviral barcoding with somatic CRISPR-Cas9-mediated genome editing to functionally investigate candidate r
Externí odkaz:
https://doaj.org/article/0a467d5273d64bf6976383eac519d5b0
Autor:
Angela Tolwani, Magdalena Matusiak, Nam Bui, Erna Forgó, Sushama Varma, Lucia Baratto, Andrei Iagaru, Alexander J. Lazar, Matt van de Rijn, Joanna Przybyl
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-10 (2021)
Abstract Metabolic reprogramming of tumor cells and the increase of glucose uptake is one of the hallmarks of cancer. In order to identify metabolic pathways activated in leiomyosarcoma (LMS), we analyzed transcriptomic profiles of distinct subtypes
Externí odkaz:
https://doaj.org/article/fc3aae85255741adb708ed42e7403540
Autor:
Andrew J. Gentles, Angela Bik-Yu Hui, Weiguo Feng, Armon Azizi, Ramesh V. Nair, Gina Bouchard, David A. Knowles, Alice Yu, Youngtae Jeong, Alborz Bejnood, Erna Forgó, Sushama Varma, Yue Xu, Amanda Kuong, Viswam S. Nair, Rob West, Matt van de Rijn, Chuong D. Hoang, Maximilian Diehn, Sylvia K. Plevritis
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-22 (2020)
Abstract Background Tumors comprise a complex microenvironment of interacting malignant and stromal cell types. Much of our understanding of the tumor microenvironment comes from in vitro studies isolating the interactions between malignant cells and
Externí odkaz:
https://doaj.org/article/cc0f2098680f4d72b3ab8a49201dc29f
Autor:
Joanna Przybyl, Lien Spans, Kristen Ganjoo, Nam Bui, David Mohler, Jeffrey Norton, George Poultsides, Maria Debiec-Rychter, Matt van de Rijn
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
High-level amplification of MDM2 and other genes in the 12q13–15 locus is a hallmark genetic feature of well-differentiated and dedifferentiated liposarcomas (WDLPS and DDLPS, respectively). Detection of this genomic aberration in plasma cell-free
Externí odkaz:
https://doaj.org/article/2d53d83c1672452da1da60f50e69f872
Autor:
Claire Baniel, Christopher H. Yoo, Alice Jiang, Rie von Eyben, David G. Mohler, Kristen Ganjoo, Nam Bui, Sarah S. Donaldson, Lynn Million, Matt van de Rijn, Justin Moon Oh, Susan M. Hiniker
Publikováno v:
Practical Radiation Oncology. 13:e301-e307
Tenosynovial giant cell tumor (TGCT) is a rare proliferative disorder of synovial membrane that previously was known as pigmented villonodular synovitis (PVNS). Primary treatment involves surgical resection, however, complete removal of all disease i
Autor:
Mushriq Al-Jazrawe, Steven Xu, Raymond Poon, Qingxia Wei, Joanna Przybyl, Sushama Varma, Matt van de Rijn, Benjamin A. Alman
Publikováno v:
Cancer Research Communications. 3:697-708
The interaction between neoplastic and stromal cells within a tumor mass plays an important role in cancer biology. However, it is challenging to distinguish between tumor and stromal cells in mesenchymal tumors because lineage-specific cell surface
Autor:
David G.P. van IJzendoorn, Magdalena Matusiak, Gregory W. Charville, Geert Spierenburg, Sushama Varma, Deana R.C. Colburg, Michiel A.J. van de Sande, Kirsten van Langevelde, David G. Mohler, Kristen N. Ganjoo, Nam Q. Bui, Raffi S. Avedian, Judith V.M.G. Bovée, Robert Steffner, Robert B. West, Matt van de Rijn
Publikováno v:
Clinical Cancer Research, 28(22), 4934-4946. AMER ASSOC CANCER RESEARCH
Purpose: A major component of cells in tenosynovial giant cell tumor (TGCT) consists of bystander macrophages responding to CSF1 that is overproduced by a small number of neoplastic cells with a chromosomal translocation involving the CSF1 gene. An a
Autor:
Nam Q. Bui, Neda Nemat-Gorgani, Ajay Subramanian, Ileana A. Torres, Marta Lohman, Timothy J. Sears, Matt van de Rijn, Gregory W. Charville, Hans-Christoph Becker, David S. Wang, Gloria L. Hwang, Kristen N. Ganjoo, Everett J. Moding
Publikováno v:
Clinical Cancer Research.
Purpose: Immune checkpoint inhibition has led to promising responses in soft tissue sarcomas (STSs), but the majority of patients do not respond and biomarkers of response will be crucial. Local ablative therapies may augment systemic responses to im
Autor:
Inga-Marie Schaefer, Yuexiang Wang, Cher-wei Liang, Nacef Bahri, Anna Quattrone, Leona Doyle, Adrian Mariño-Enríquez, Alexandra Lauria, Meijun Zhu, Maria Debiec-Rychter, Susanne Grunewald, Jaclyn F. Hechtman, Armelle Dufresne, Cristina R. Antonescu, Carol Beadling, Ewa T. Sicinska, Matt van de Rijn, George D. Demetri, Marc Ladanyi, Christopher L. Corless, Michael C. Heinrich, Chandrajit P. Raut, Sebastian Bauer, Jonathan A. Fletcher
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
In gastrointestinal stromal tumours early mutations in known genes are frequently followed by chromosome 14q deletion. Here the authors find mutations resulting in loss of MAX protein expression conserved between primary tumours and metastases in the
Externí odkaz:
https://doaj.org/article/f99b7b0f7dfb4944b7bbfdf9272bbf4d