Výsledky vyhledávání

Multiple N-Methylation of MT-II Backbone Amide Bonds Leads to Melanocortin Receptor Subtype hMC1R Selectivity: Pharmacological and Conformational Studies

Autor: Johannes G. Beck, Lucas Doedens, Horst Kessler, Florian Opperer, Matt Dedek, Victor J. Hruby, Erin S. Palmer, Minying Cai

Publikováno v: Journal of the American Chemical Society. 132:8115-8128

Multiple N-methylation is a novel technology to improve bioavailability of peptides and increase receptor subtype selectivity. This technique has been applied here to the superpotent but nonselective cyclic peptide MT-II. A library of all possible 31

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468edb7745ff65c0ab7e63036bef7394
https://doi.org/10.1021/ja101428m

Zobrazit plný text záznamu

Induction of antioxidant and detoxification response by oxidants in cardiomyocytes: Evidence from gene expression profiling and activation of Nrf2 transcription factor

Autor: Jeffery Johnson, Steve Morrissy, Matt Dedek, Sally E. Purdom-Dickinson, Yan Lin, Qin M. Chen

Publikováno v: Journal of Molecular and Cellular Cardiology. 42:159-176

Mild or low doses of oxidants are known to prime cells towards resistance against further damage. In cardiomyocytes, we found that pretreatment with 100 microM H(2)O(2) prevents the cells from apoptosis induced by doxorubicin (Dox). Affymetrix microa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f27c2b7c23a3172cac6233b43a0fb03
https://doi.org/10.1016/j.yjmcc.2006.09.012

Zobrazit plný text záznamu

Peptide and non-peptide mimetics utilize different pathways for signal transduction

Autor: Victor J, Hruby, Minying, Cai, Matt, Dedek, Hongchang, Qu, Erin, Palmer, Alexander, Mayorov, Dev, Trivedi, George, Tsaprailis, Yingqui, Yang

Publikováno v: Advances in experimental medicine and biology. 611

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3586b9764c9be307e554128153779154
https://pubmed.ncbi.nlm.nih.gov/19400204

Zobrazit plný text záznamu

Peptide and Non-Peptide Mimetics Utilize Different Pathways for Signal Transduction

Autor: Yingqui Yang, George Tsaprailis, Hongchang Qu, Minying Cai, Alexander V. Mayorov, Erin S. Palmer, Matt Dedek, Dev Trivedi, Victor J. Hruby

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9780387736563

Introduction Despite the central importance of peptides as drugs such as insulin, oxytocin, calcitonin, ace inhibitors, etc., there has been a prejudice against developing peptide drugs. Instead large efforts are made to develop non-peptide small mol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df65f1120a589df8f623769b094ec466
https://doi.org/10.1007/978-0-387-73657-0_137

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání