Variants in the β-globin locus are associated with pneumonia in African American children

Autor: Halligan, Nadine L.N., Hanks, Sarah C., Matsuo, Karen, Martins, Taylor, Zöllner, Sebastian, Quasney, Michael W., Scott, Laura J., Dahmer, Mary K.

Publikováno v: In Human Genetics and Genomics Advances 9 January 2025 6(1)

Relationship between Body Mass Index, C-Peptide, and Delta-5-Desaturase Enzyme Activity Estimates in Adult Males.

Autor: Pickens, C. Austin¹, Matsuo, Karen H.¹, Fenton, Jenifer I.¹ imigjeni@msu.edu

Publikováno v: PLoS ONE. 3/29/2016, Vol. 11 Issue 3, p1-13. 13p.

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.

Autor: Flannick J; Program in Metabolism, Broad Institute, Cambridge, MA, USA. flannick@broadinstitute.org.; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA. flannick@broadinstitute.org.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. flannick@broadinstitute.org.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA. flannick@broadinstitute.org., Mercader JM; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Fuchsberger C; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Institute for Biomedicine, Eurac Research, Bolzano, Italy.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Udler MS; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Mahajan A; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Wessel J; Department of Epidemiology, Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA.; Department of Medicine, School of Medicine, Indiana University, Indianapolis, IN, USA.; Diabetes Translational Research Center, Indiana University, Indianapolis, IN, USA., Teslovich TM; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA., Caulkins L; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA., Koesterer R; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA., Barajas-Olmos F; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Blackwell TW; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Boerwinkle E; Human Genetics Center, Department of Epidemiology Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Brody JA; Cardiovascular Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Centeno-Cruz F; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Chen L; Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Chen S; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Contreras-Cubas C; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Córdova E; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Cortes M; Broad Institute of MIT and Harvard, Cambridge, MA, USA., DeFronzo RA; Department of Medicine, University of Texas Health Science Center, San Antonio, TX, USA., Dolan L; Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Drews KL; Biostatistics Center, George Washington University, Rockville, MD, USA., Elliott A; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.; Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Floyd JS; Department of Medicine and Epidemiology, University of Washington, Seattle, WA, USA., Gabriel S; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Garay-Sevilla ME; Department of Medicine, The University of Chicago, Chicago, IL, USA.; Department of Human Genetics, The University of Chicago, Chicago, IL, USA., García-Ortiz H; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Gross M; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., Han S; Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, South Korea., Heard-Costa NL; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.; National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA., Jackson AU; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Jørgensen ME; Steno Diabetes Center Copenhagen, Gentofte, Denmark.; National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.; Greenland Centre for Health Research, University of Greenland, Nuuk, Greenland., Kang HM; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Kelsey M; Biostatistics Center, George Washington University, Rockville, MD, USA., Kim BJ; Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, South Korea., Koistinen HA; Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.; University of Helsinki and Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Department of Medicin, Kuopio University Hospital, Kuopio, Finland., Leader JB; Geisinger Health System, Danville, PA, USA., Linneberg A; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.; Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Liu J; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore., Lyssenko V; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.; Department of Clinical Science, University of Bergen, Bergen, Norway., Manning AK; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard University, Boston, MA, USA., Marcketta A; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA., Malacara-Hernandez JM; Department of Medicine, The University of Chicago, Chicago, IL, USA.; Department of Human Genetics, The University of Chicago, Chicago, IL, USA., Martínez-Hernández A; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Matsuo K; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Mayer-Davis E; University of North Carolina Chapel Hill, Chapel Hill, NC, USA., Mendoza-Caamal E; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Mohlke KL; Department of Genetics, University of North Carolina Chapel Hill, Chapel Hill, NC, USA., Morrison AC; Human Genetics Center, Department of Epidemiology Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Ndungu A; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Ng MCY; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., O'Dushlaine C; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA., Payne AJ; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Pihoker C; Seattle Children's Hospital, Seattle, WA, USA., Post WS; Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., Preuss M; Charles R. Bronfman Institute of Personalized Medicine, Mount Sinai School of Medicine, New York, NY, USA., Psaty BM; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA., Vasan RS; National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.; Preventive Medicine & Epidemiology, Medicine, Boston University School of Medicine, Boston, MA, USA., Rayner NW; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, UK., Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA, USA., Revilla-Monsalve C; Instituto Mexicano del Seguro Social SXXI, Mexico City, Mexico., Robertson NR; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Santoro N; Department of Pediatrics, Yale University, New Haven, CT, USA., Schurmann C; Charles R. Bronfman Institute of Personalized Medicine, Mount Sinai School of Medicine, New York, NY, USA., So WY; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Soberón X; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Stringham HM; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Strom TM; Institute of Human Genetics, Technische Universität München, Munich, Germany.; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Tam CHT; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Thameem F; Health Science Center, Department of Biochemistry, Faculty of Medicine, Kuwait University, Safat, Kuwait., Tomlinson B; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Torres JM; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Tracy RP; Department of Pathology and Laboratory Medicine, The Robert Larner M.D. College of Medicine, University of Vermont, Burlington, VT, USA.; Department of Biochemistry, The Robert Larner M.D. College of Medicine, University of Vermont, Burlington, VT, USA., van Dam RM; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA., Vujkovic M; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA., Wang S; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Welch RP; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Witte DR; Department of Public Health, Aarhus University, Aarhus, Denmark.; Danish Diabetes Academy, Odense, Denmark., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Duke-NUS Medical School Singapore, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore., Atzmon G; Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA.; Faculty of Natural Science, University of Haifa, Haifa, Israel.; Department of Genetics, Albert Einstein College of Medicine, New York, NY, USA., Barzilai N; Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA.; Department of Genetics, Albert Einstein College of Medicine, New York, NY, USA., Blangero J; Department of Human Genetics, University of Texas Rio Grande Valley, Edinburg, TX, USA.; South Texas Diabetes and Obesity Institute, Brownsville, TX, USA., Bonnycastle LL; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Bowden DW; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital NHS Trust, Southall, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK., Chan E; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore., Cheng CY; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Cho YS; Department of Biomedical Science, Hallym University, Chuncheon, South Korea., Collins FS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., de Vries PS; Human Genetics Center, Department of Epidemiology Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Duggirala R; Department of Human Genetics, University of Texas Rio Grande Valley, Edinburg, TX, USA.; South Texas Diabetes and Obesity Institute, Brownsville, TX, USA., Glaser B; Endocrinology and Metabolism Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel., Gonzalez C; Unidad de Diabetes y Riesgo Cardiovascular, Instituto Nacional de Salud Pública, Cuernavaca, Mexico., Gonzalez ME; Centro de Estudios en Diabetes, Mexico City, Mexico., Groop L; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.; Institute for Molecular Genetics Finland, University of Helsinki, Helsinki, Finland., Kooner JS; National Heart and Lung Institute, Cardiovascular Sciences, Imperial College London, London, UK., Kwak SH; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.; Department of Medicin, Kuopio University Hospital, Kuopio, Finland., Lehman DM; Department of Medicine, University of Texas Health Science Center, San Antonio, TX, USA., Nilsson P; Department of Clinical Sciences, Medicine, Lund University, Malmö, Sweden., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Tai ES; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.; Duke-NUS Medical School Singapore, Singapore, Singapore., Tuomi T; Institute for Molecular Genetics Finland, University of Helsinki, Helsinki, Finland.; Folkhälsan Research Centre, Helsinki, Finland.; Department of Endocrinology, Abdominal Centre, Helsinki University Hospital, Helsinki, Finland.; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland., Tuomilehto J; Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.; Center for Vascular Prevention, Danube University Krems, Krems, Austria.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.; Instituto de Investigacion Sanitaria del Hospital Universario LaPaz (IdiPAZ), University Hospital LaPaz, Autonomous University of Madrid, Madrid, Spain., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA., Aguilar-Salinas CA; Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico., Bottinger E; Charles R. Bronfman Institute of Personalized Medicine, Mount Sinai School of Medicine, New York, NY, USA., Burke B; Biostatistics Center, George Washington University, Rockville, MD, USA., Carey DJ; Geisinger Health System, Danville, PA, USA., Chan JCN; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Dupuis J; National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Frossard P; Center for Non-Communicable Diseases, Karachi, Pakistan., Heckbert SR; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Hwang MY; Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, South Korea., Kim YJ; Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, South Korea., Kirchner HL; Geisinger Health System, Danville, PA, USA., Lee JY; Department of Business Data Convergence, Chungbuk National University, Gyeonggi-do, South Korea., Lee J; Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, South Korea., Loos RJF; Charles R. Bronfman Institute of Personalized Medicine, Mount Sinai School of Medicine, New York, NY, USA.; The Mindich Child Health and Development Insititute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ma RCW; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Morris AD; Clinical Research Centre, Centre for Molecular Medicine, Ninewells Hospital and Medical School, Dundee, UK., O'Donnell CJ; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Section of Cardiology, Department of Medicine, VA Boston Healthcare, Boston, MA, USA.; Brigham and Women's Hospital, Boston, MA, USA.; Intramural Administration Management Branch, National Heart Lung and Blood Institute, NIH, Framingham, MA, USA., Palmer CNA; Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, UK., Pankow J; Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA., Park KS; National Heart and Lung Institute, Cardiovascular Sciences, Imperial College London, London, UK.; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea.; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea., Rasheed A; Center for Non-Communicable Diseases, Karachi, Pakistan., Saleheen D; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA.; Center for Non-Communicable Diseases, Karachi, Pakistan., Sim X; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore., Small KS; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Teo YY; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.; Life Sciences Institute, National University of Singapore, Singapore, Singapore.; Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore., Haiman C; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Hanis CL; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Henderson BE; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Orozco L; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Tusié-Luna T; Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico.; Instituto de Investigaciones Biomédicas, Departamento de Medicina Genómica y Toxicología, Universidad Nacional Autónoma de México, Mexico City, Mexico., Dewey FE; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA., Baras A; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA., Gieger C; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany., Meitinger T; Institute of Human Genetics, Technische Universität München, Munich, Germany.; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Strauch K; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Neuherberg, Germany., Lange L; Department of Medicine, University of Colorado Denver, Aurora, CO, USA., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Zeitler P; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Dabelea D; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA., Abecasis G; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Bell GI; Department of Medicine, The University of Chicago, Chicago, IL, USA.; Department of Human Genetics, The University of Chicago, Chicago, IL, USA., Cox NJ; Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA., Seielstad M; Department of Laboratory Medicine & Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.; Blood Systems Research Institute, San Francisco, CA, USA., Sladek R; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Division of Endocrinology and Metabolism, Department of Medicine, McGill University, Montreal, Quebec, Canada.; McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada., Meigs JB; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., Rich SS; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Rotter JI; Department of Pediatrics, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.; Department of Medicine, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.; Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Altshuler D; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.; Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA., Burtt NP; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA., Scott LJ; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Morris AP; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Biostatistics, University of Liverpool, Liverpool, UK., Florez JC; Program in Metabolism, Broad Institute, Cambridge, MA, USA.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., McCarthy MI; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Boehnke M; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.

Publikováno v: Nature [Nature] 2019 Jun; Vol. 570 (7759), pp. 71-76. Date of Electronic Publication: 2019 May 22.