Simultaneous substrate and ubiquitin modification recognition by bispecific antibodies enables detection of ubiquitinated RIP1 and RIP2.

Autor: Goncharov T; Department of Early Discovery Biochemistry, Genentech, South San Francisco, CA 94080, USA.; Department of Immunology Discovery, Genentech, South San Francisco, CA 94080, USA., Kőműves LG; Department of Pathology, Genentech, South San Francisco, CA 94080, USA., Kist M; Department of Early Discovery Biochemistry, Genentech, South San Francisco, CA 94080, USA.; Department of Immunology Discovery, Genentech, South San Francisco, CA 94080, USA., Castellanos ER; Department of Structural Biology, Genentech, South San Francisco, CA 94080, USA., Witt A; Department of Early Discovery Biochemistry, Genentech, South San Francisco, CA 94080, USA.; Department of Immunology Discovery, Genentech, South San Francisco, CA 94080, USA., Fedorova AV; Department of Early Discovery Biochemistry, Genentech, South San Francisco, CA 94080, USA., Izrael-Tomasevic A; Department of Microchemistry, Proteomics and Lipidomics, Genentech, South San Francisco, CA 94080, USA., Yu K; Department of Microchemistry, Proteomics and Lipidomics, Genentech, South San Francisco, CA 94080, USA., Keir M; Department of Human Pathobiology and OMNI Reverse Translation, Genentech, South San Francisco, CA 94080, USA., Matsumoto ML; Department of Structural Biology, Genentech, South San Francisco, CA 94080, USA., Vucic D; Department of Early Discovery Biochemistry, Genentech, South San Francisco, CA 94080, USA.; Department of Immunology Discovery, Genentech, South San Francisco, CA 94080, USA.

Publikováno v: Science signaling [Sci Signal] 2024 Jan 16; Vol. 17 (819), pp. eabn1101. Date of Electronic Publication: 2024 Jan 16.

Potent Killing of Pseudomonas aeruginosa by an Antibody-Antibiotic Conjugate.

Autor: Kajihara KK; Department of Infectious Diseases, Genentech, Inc., South San Francisco, California, USA., Pantua H; Department of Infectious Diseases, Genentech, Inc., South San Francisco, California, USA., Hernandez-Barry H; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California, USA., Hazen M; Department of Antibody Engineering, Genentech, Inc., South San Francisco, California, USA., Deshmukh K; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California, USA., Chiang N; Department of Antibody Engineering, Genentech, Inc., South San Francisco, California, USA., Ohri R; Department of Protein Chemistry, Genentech, Inc., South San Francisco, California, USA., Castellanos ER; Department of Structural Biology, Genentech, Inc., South San Francisco, California, USA., Martin L; Department of BioMolecular Resources, Genentech, Inc., South San Francisco, California, USA., Matsumoto ML; Department of Structural Biology, Genentech, Inc., South San Francisco, California, USA., Payandeh J; Department of Infectious Diseases, Genentech, Inc., South San Francisco, California, USA.; Department of Antibody Engineering, Genentech, Inc., South San Francisco, California, USA.; Department of Structural Biology, Genentech, Inc., South San Francisco, California, USA., Storek KM; Department of Infectious Diseases, Genentech, Inc., South San Francisco, California, USA., Schneider K; Department of Antibody Engineering, Genentech, Inc., South San Francisco, California, USA., Smith PA; Department of Infectious Diseases, Genentech, Inc., South San Francisco, California, USA., Koehler MFT; Department of Medicinal Chemistry; Genentech, Inc., South San Francisco, California, USA., Tsai SP; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California, USA., Vandlen R; Department of Protein Chemistry, Genentech, Inc., South San Francisco, California, USA., Loyet KM; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California, USA., Nakamura G; Department of Antibody Engineering, Genentech, Inc., South San Francisco, California, USA., Pillow T; Department of Medicinal Chemistry; Genentech, Inc., South San Francisco, California, USA., Seshasayee D; Department of Antibody Engineering, Genentech, Inc., South San Francisco, California, USA., Kapadia SB; Department of Infectious Diseases, Genentech, Inc., South San Francisco, California, USA., Hazenbos WLW; Department of Infectious Diseases, Genentech, Inc., South San Francisco, California, USA.

Publikováno v: MBio [mBio] 2021 Jun 29; Vol. 12 (3), pp. e0020221. Date of Electronic Publication: 2021 Jun 01.

Structure of the secretory immunoglobulin A core.

Autor: Kumar N; Department of Structural Biology, Genentech, Inc., South San Francisco, CA, USA 94080., Arthur CP; Department of Structural Biology, Genentech, Inc., South San Francisco, CA, USA 94080., Ciferri C; Department of Structural Biology, Genentech, Inc., South San Francisco, CA, USA 94080. ciferri.claudio@gene.com matsumoto.marissa@gene.com., Matsumoto ML; Department of Structural Biology, Genentech, Inc., South San Francisco, CA, USA 94080. ciferri.claudio@gene.com matsumoto.marissa@gene.com.

Publikováno v: Science (New York, N.Y.) [Science] 2020 Feb 28; Vol. 367 (6481), pp. 1008-1014. Date of Electronic Publication: 2020 Feb 06.

STING induces HOIP-mediated synthesis of M1 ubiquitin chains to stimulate NF-κB signaling.

Autor: Fischer TD; Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. fischertad@nih.gov., Bunker EN; Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Zhu PP; Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Le Guerroué F; Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; Single Cell Biomarkers UTechS, Institut Pasteur, Université Paris Cité, Paris, France., Hadjian M; Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Dominguez-Martin E; Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA., Scavone F; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA.; Department of Biology, Stanford University, Stanford, CA, USA., Cohen R; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA., Yao T; Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA., Wang Y; Mass Spectrometry, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA., Werner A; Stem Cell Biochemistry Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA., Youle RJ; Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. youler@ninds.nih.gov.

Publikováno v: The EMBO journal [EMBO J] 2024 Nov 22. Date of Electronic Publication: 2024 Nov 22.

The role of Aurora kinase A in hepatocellular carcinoma: Unveiling the intriguing functions of a key but still underexplored factor in liver cancer.

Autor: Grisetti, Luca^1,2 (AUTHOR), Garcia, Clarissa J. C.^1,2 (AUTHOR), Saponaro, Anna A.¹ (AUTHOR), Tiribelli, Claudio¹ (AUTHOR), Pascut, Devis¹ (AUTHOR) devis.pascut@fegato.it

Publikováno v: Cell Proliferation. Aug2024, Vol. 57 Issue 8, p1-18. 18p.