Trametinib suppresses chemotherapy-induced cold and mechanical allodynia via inhibition of extracellular-regulated protein kinase 1/2 activation

Autor: Tsubaki, Masanobu, Takeda, Tomoya, Matsumoto, Mikihiro, Kato, Natsuki, Asano, Ryo-ta, Imano, Motohiro, Satou, Takao, Nishida, Shozo

Chemotherapy-induced neuropathy is a common, dose-dependent adverse effect of some anti-cancer drugs and leads to discontinuation of chemotherapy and detrimental dose reductions, thereby affecting the quality of life of cancer patients. Currently, no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fa75df21b0fd91d8355322a447c8c623
https://europepmc.org/articles/PMC6079147/

Gabapentin and Duloxetine Prevent Oxaliplatin- and Paclitaxel-Induced Peripheral Neuropathy by Inhibiting Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Phosphorylation in Spinal Cords of Mice.

Autor: Kato N; Division of Pharmacotherapy, Kindai University Faculty of Pharmacy, Kowakae, Higashi-Osaka 577-8502, Japan., Tateishi K; Division of Pharmacotherapy, Kindai University Faculty of Pharmacy, Kowakae, Higashi-Osaka 577-8502, Japan., Tsubaki M; Division of Pharmacotherapy, Kindai University Faculty of Pharmacy, Kowakae, Higashi-Osaka 577-8502, Japan., Takeda T; Division of Pharmacotherapy, Kindai University Faculty of Pharmacy, Kowakae, Higashi-Osaka 577-8502, Japan., Matsumoto M; Division of Pharmacotherapy, Kindai University Faculty of Pharmacy, Kowakae, Higashi-Osaka 577-8502, Japan., Tsurushima K; Division of Pharmacotherapy, Kindai University Faculty of Pharmacy, Kowakae, Higashi-Osaka 577-8502, Japan.; Department of Pharmacy, Sakai City Medical Center, Sakai 593-8304, Japan., Ishizaka T; Department of Pharmacy, Sakai City Medical Center, Sakai 593-8304, Japan., Nishida S; Division of Pharmacotherapy, Kindai University Faculty of Pharmacy, Kowakae, Higashi-Osaka 577-8502, Japan.

Publikováno v: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2020 Dec 31; Vol. 14 (1). Date of Electronic Publication: 2020 Dec 31.

Trametinib suppresses chemotherapy-induced cold and mechanical allodynia via inhibition of extracellular-regulated protein kinase 1/2 activation.

Autor: Tsubaki M; Division of Pharmacotherapy, Kindai University School of Pharmacy Kowakae, Higashi-Osaka, Japan., Takeda T; Division of Pharmacotherapy, Kindai University School of Pharmacy Kowakae, Higashi-Osaka, Japan., Matsumoto M; Division of Pharmacotherapy, Kindai University School of Pharmacy Kowakae, Higashi-Osaka, Japan., Kato N; Division of Pharmacotherapy, Kindai University School of Pharmacy Kowakae, Higashi-Osaka, Japan., Asano RT; Division of Pharmacotherapy, Kindai University School of Pharmacy Kowakae, Higashi-Osaka, Japan., Imano M; Department of Surgery, School of Medicine, Kindai University Osakasayama, Osaka, Japan., Satou T; Department of Pathology, School of Medicine, Kindai University Osakasayama, Osaka, Japan., Nishida S; Division of Pharmacotherapy, Kindai University School of Pharmacy Kowakae, Higashi-Osaka, Japan.

Publikováno v: American journal of cancer research [Am J Cancer Res] 2018 Jul 01; Vol. 8 (7), pp. 1239-1248. Date of Electronic Publication: 2018 Jul 01 (Print Publication: 2018).