Extended functional repertoire for human copper chaperones

Autor: Matson Dzebo Maria, Ariöz Candan, Wittung-Stafshede Pernilla

Publikováno v: Biomolecular Concepts, Vol 7, Iss 1, Pp 29-39 (2016)

Copper (Cu) ions are cofactors in many essential enzymes. As free Cu ions are toxic, most organisms have highly specialized Cu transport systems involving dedicated proteins. The human cytoplasmic Cu chaperone Atox1 delivers Cu to P1B-type ATPases in

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The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation.

Autor: Grasso M; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Bond GJ; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Biochemistry Major Program, College of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Kim YJ; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Boyd S; Department of Biological Sciences, University of Texas at Dallas, Richardson, Texas, USA., Matson Dzebo M; Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden., Valenzuela S; Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden., Tsang T; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Schibrowsky NA; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Alwan KB; Department of Chemical Physiology and Biochemistry, School of Medicine, Oregon Health and Science University, Portland, Oregon, USA., Blackburn NJ; Department of Chemical Physiology and Biochemistry, School of Medicine, Oregon Health and Science University, Portland, Oregon, USA., Burslem GM; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Wittung-Stafshede P; Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden., Winkler DD; Department of Biological Sciences, University of Texas at Dallas, Richardson, Texas, USA., Marmorstein R; Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Brady DC; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address: bradyd@pennmedicine.upenn.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2021 Dec; Vol. 297 (6), pp. 101314. Date of Electronic Publication: 2021 Oct 27.