Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Mats Holmqvist"'
Autor:
Claudia Schäfer, Yawen Ju, Youngbin Tak, Cesar Vazquez, Sangyoon J. Han, Edwin Tan, Jerry W. Shay, Mats Holmqvist, Gaudenz Danuser, William M. Schopperle, Glenn Bubley
Publikováno v:
Heliyon, Vol 6, Iss 1, Pp e03263- (2020)
Purpose: Over 90% of all cancer related deaths are due to metastasis. However, current diagnostic tools can't reliably discriminate between invasive and localized cancers. Patients and methods: In this proof-of-concept study, we employed the embryoni
Externí odkaz:
https://doaj.org/article/520573ffb5aa479f9218d8f1e9d2ed89
Autor:
Chen Christine Hiu-Tung, Lei Jiang, Mats Holmqvist, Sheri Bickford, Ping Wang, Michael Shultz, Mannangatti Selvaraj, Yan Yan-Neale, Haiyan Zhang, Lewis Whitehead, Gang Liu, Xueying Cao, Meier Hsu, Chetan Patel, Young Shin Cho, Peter Atadja, Jianmei Fan, Joghee Raju Suresh, Kristen Buteau, Laszlo Urban, Liping Zhou, N Davis, Qiang Lu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4909-4912
The design, synthesis and biological evaluation of a novel series of isoindoline-based hydroxamates is described. Several analogs were shown to inhibit HDAC1 with IC50 values in the low nanomolar range and inhibit cellular proliferation of HCT116 hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339f0a4d90fe78aaf5611b03b0dc11cc
https://doi.org/10.1016/j.bmcl.2011.06.015
https://doi.org/10.1016/j.bmcl.2011.06.015
Autor:
Chen Christine Hiu-Tung, Remiszewski Stacy W, Jianmei Fan, Alex Fekete, Brant Firestone, Joseph D. Growney, Christopher T. Meta, Joe Eckman, Dyuti Majumdar, Ping Wang, Peter Atadja, Vinita Uttamsingh, Liping Zhou, Laszlo Urban, Qiang Lu, Meier Hsu, Suzanne Skolnik, Lei Jiang, Tim Ramsey, Martin Traebert, Yan Yan-Neale, Minying Pu, Julie Flynn, Lawrence Blas Perez, Yung-Mae Yao, Xueying Cao, Franco Lombardo, Steven Whitebread, Mats Holmqvist, Lewis Whitehead, Young Shin Cho, Paul Kwon, N Davis, Jack Green, Daniel Jansson, Michael Shultz, Gang Liu
Publikováno v:
Journal of Medicinal Chemistry. 54:4752-4772
Histone deacetylase (HDAC) inhibitors have shown promise in treating various forms of cancer. However, many HDAC inhibitors from diverse structural classes have been associated with QT prolongation in humans. Inhibition of the human ether a-go-go rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c444090ceb6d32a590072a95df83c006
https://doi.org/10.1021/jm200388e
https://doi.org/10.1021/jm200388e
Autor:
Dmitri Mikhailov, Yucheng Ni, Christopher Hogan, Qiang Lu, Gul Erdemli, Yingxin Lin, Haiyan Zhang, Liping Zhou, Xueying Cao, Mats Holmqvist, Laszlo Urban, Mary Ellen Digan, Yan Tony Lee
Publikováno v:
ASSAY and Drug Development Technologies. 8:766-780
The normal electrophysiologic behavior of the heart is determined by the integrated activity of specific cardiac ionic currents. Mutations in genes encoding the molecular components of individual cardiac ion currents have been shown to result in mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d096d39f65594d276ca2f2a67c653e99
https://doi.org/10.1089/adt.2010.0333
https://doi.org/10.1089/adt.2010.0333
Autor:
Juliette Johnson, Qin Chen, Cristian Ionescu-Zanetti, Mats Holmqvist, Tony Lee, Xueying Cao, Gul Erdemli, Andrew P. Golden, J. Tanner Nevill, Nianzhen Li, Laszlo Urban
Publikováno v:
Assay and drug development technologies. 9(6)
Ion channel assays are essential in drug discovery, not only for identifying promising new clinical compounds, but also for minimizing the likelihood of potential side effects. Both applications demand optimized throughput, cost, and predictive accur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fbb60568024d26f2c4224fd87795a58
https://pubmed.ncbi.nlm.nih.gov/21561375
https://pubmed.ncbi.nlm.nih.gov/21561375
Publikováno v:
Biophysical Journal. 100(3)
Center for Proteomic Chemistry, Novartis Institutes for BioMedical Research Inc., 250 Massachusetts Avenue Cambridge, MA 02139, USA.QPatch HTX is an automated patch clamp system with greatly increased throughput over conventional patch clamp methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8137baa5c4a9d1e5bd94773612ddf8c
Publikováno v:
Biophysical Journal. 100:270a-271a
QPatch HTX has the highest throughput in the QPatch series. With signature features such as unattended operations, eight pipettes and the integrated microfluidic glass flow channels of the QPlates, the QPatch HTXis well suited for testing ligand gate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26f01cb768fa9d69903ae39dcfb8418
https://doi.org/10.1016/j.bpj.2010.12.1687
https://doi.org/10.1016/j.bpj.2010.12.1687
Autor:
Laszlo Urban, Christopher Hogan, Yucheng Ni, Gul Erdemli, Marry E. Digan, Dmitri Mikhailov, Mats Holmqvist, Hiyan Zhang, Tony Lee, Xueying Cao
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 64:e8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c72e2c7ee8c172ccd239a509f104b0f6
https://doi.org/10.1016/j.vascn.2011.03.031
https://doi.org/10.1016/j.vascn.2011.03.031
Autor:
Andrew P. Golden, Nianzhen Li, Qin Chen, Tony Lee, Tanner Nevill, Xueying Cao, Juliette Johnson, Gül Erdemli, Cristian Ionescu-Zanetti, Laszlo Urban, Mats Holmqvist
Publikováno v:
Assay & Drug Development Technologies; Dec2011, Vol. 9 Issue 6, p608-619, 12p
Autor:
Xueying Cao, Yan Tony Lee, Mats Holmqvist, Yingxin Lin, Yucheng Ni, Dmitri Mikhailov, Haiyan Zhang, Christopher Hogan, Liping Zhou, Qiang Lu, Mary Ellen Digan, Laszlo Urban, Gül Erdemli
Publikováno v:
Assay & Drug Development Technologies; Dec2010, Vol. 8 Issue 6, p766-780, 15p