Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Mats Åkesson"'
Autor:
Anna Rosén, Mats Åkesson, Björn Walse, Helena Berg, Dorthe Da Graca Thrige, Kristina Uvebrant, Per Björk
Publikováno v:
SLAS Discovery. 12:464-472
Protein-protein interactions are widely found in biological systems controlling diverse cellular events. Because these interactions are implicated in many diseases such as autoimmunity and cancer, regulation of protein-protein interactions provides i
Publikováno v:
Microbiology. 151:2209-2221
The physiological phenotype of Aspergillus nidulans was investigated for different genetic and environmental conditions of glucose repression through the quantification of in vivo fluxes in the central carbon metabolism using 13C-metabolic-flux analy
Publikováno v:
FEMS Yeast Research. 5:703-709
Glyoxylate biosynthesis in Saccharomyces cerevisiae is traditionally mainly ascribed to the reaction catalyzed by isocitrate lyase (Icl), which converts isocitrate to glyoxylate and succinate. However, Icl is generally reported to be repressed by glu
Publikováno v:
Yeast. 22:1155-1169
Sample preparation is considered one of the limiting steps in microbial metabolome analysis. Eukaryotes and prokaryotes behave very differently during the several steps of classical sample preparation methods for analysis of metabolites. Even within
Publikováno v:
Biotechnology and Bioengineering. 86:209-216
A dynamic model describing carbon atom transitions in the central metabolism of Saccharomyces cerevisiae is used to investigate the influence of transamination reactions and protein turnover on the transient behavior of (13)C-labeling chemostat exper
Publikováno v:
European Journal of Biochemistry. 270:4243-4253
The topology of central carbon metabolism of Aspergillus niger was identified and the metabolic network reconstructed, by integrating genomic, biochemical and physiological information available for this microorganism and other related fungi. The rec
Publikováno v:
Control Engineering Practice. 9:709-723
Production of various proteins can today be made using genetically modified Escherichia coli bacteria. In cultivations of E. coli it is important to avoid accumulation of the by-product acetate. Formation of acetate occurs when the specific glucose u
Publikováno v:
IFAC Proceedings Volumes. 34:213-218
A strategy for feedback control of the glucose feed rate in cultivations of E.coli is discussed. By making probing pulses in the feedrate it is possible to detect and avoid undesirable by-productformation using a standard dissolved oxygen sensor. The
Publikováno v:
Biotechnology and Bioengineering. 73:223-230
An automated glucose feeding strategy that avoids acetate accumulation in cultivations of Escherichia coli is discussed. We have previously described how a probing technique makes it possible to detect and avoid overflow metabolism using a dissolved
Publikováno v:
Biotechnology and Bioengineering. 64:590-598
Recombinant protein production in Escherichia coli can be significantly reduced by acetate accumulation. It is demonstrated that acetate production can be detected on-line with a standard dissolved oxygen sensor by superimposing short pulses to the s