Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Mats, Ohlin"'
Autor:
Niklas Berndt Thalén, Maximilian Karlander, Magnus Lundqvist, Helena Persson, Camilla Hofström, S. Pauliina Turunen, Magdalena Godzwon, Anna-Luisa Volk, Magdalena Malm, Mats Ohlin, Johan Rockberg
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Precise epitope determination of therapeutic antibodies is of great value as it allows for further comprehension of mechanism of action, therapeutic responsiveness prediction, avoidance of unwanted cross reactivity, and vaccine design. The g
Externí odkaz:
https://doaj.org/article/e8c8e0ec47704c01a51d5a3138a80a18
Autor:
Arman Izadi, Yasaman Karami, Eleni Bratanis, Sebastian Wrighton, Hamed Khakzad, Maria Nyblom, Berit Olofsson, Lotta Happonen, Di Tang, Martin Sundwall, Magdalena Godzwon, Yashuan Chao, Alejandro Gomez Toledo, Tobias Schmidt, Mats Ohlin, Michael Nilges, Johan Malmström, Wael Bahnan, Oonagh Shannon, Lars Malmström, Pontus Nordenfelt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Streptococcus pyogenes can cause invasive disease with high mortality despite adequate antibiotic treatments. To address this unmet need, we have previously generated an opsonic IgG1 monoclonal antibody, Ab25, targeting the bacterial M prote
Externí odkaz:
https://doaj.org/article/be6b5c313b7e4a23b226edf27ac9fea5
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionFish β-parvalbumins are common targets of allergy-causing immunity. The nature of antibody responses to such allergens determines the biological outcome following exposure to fish. Specific epitopes on these allergens recognised by antib
Externí odkaz:
https://doaj.org/article/0f0e57bd51994ea9acb1bc818db28680
Autor:
David Hueting, Karen Schriever, Rui Sun, Stelios Vlachiotis, Fanglei Zuo, Likun Du, Helena Persson, Camilla Hofström, Mats Ohlin, Karin Walldén, Marcus Buggert, Lennart Hammarström, Harold Marcotte, Qiang Pan-Hammarström, Juni Andréll, Per-Olof Syrén
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract We report the application of ancestral sequence reconstruction on coronavirus spike protein, resulting in stable and highly soluble ancestral scaffold antigens (AnSAs). The AnSAs interact with plasma of patients recovered from COVID-19 but d
Externí odkaz:
https://doaj.org/article/7efece04ed6248b3af38175bd28035f3
Autor:
Andrew M. Collins, Mats Ohlin, Martin Corcoran, James M. Heather, Duncan Ralph, Mansun Law, Jesus Martínez-Barnetche, Jian Ye, Eve Richardson, William S. Gibson, Oscar L. Rodriguez, Ayelet Peres, Gur Yaari, Corey T. Watson, William D. Lees
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionAnalysis of an individual’s immunoglobulin (IG) gene repertoire requires the use of high-quality germline gene reference sets. When sets only contain alleles supported by strong evidence, AIRR sequencing (AIRR-seq) data analysis is more
Externí odkaz:
https://doaj.org/article/aa654cd36aa94db1a0e3b47ed8578d9f
Autor:
Nerea Martín Almazán, Afsar Rahbar, Marcus Carlsson, Tove Hoffman, Linda Kolstad, Bengt Rönnberg, Mattia Russel Pantalone, Ilona Lewensohn Fuchs, Anna Nauclér, Mats Ohlin, Mariusz Sacharczuk, Piotr Religa, Stefan Amér, Christian Molnár, Åke Lundkvist, Andres Susrud, Birger Sörensen, Cecilia Söderberg-Nauclér
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108441- (2023)
Summary: Susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is highly variable and could be mediated by a cross-protective pre-immunity. We identified 14 cross-reactive peptides between SARS-CoV-2 and influenza
Externí odkaz:
https://doaj.org/article/14c7207441214d8a9312bd036a839a27
Autor:
Katherine J. L. Jackson, Justin T. Kos, William Lees, William S. Gibson, Melissa Laird Smith, Ayelet Peres, Gur Yaari, Martin Corcoran, Christian E. Busse, Mats Ohlin, Corey T. Watson, Andrew M. Collins
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The immunoglobulin genes of inbred mouse strains that are commonly used in models of antibody-mediated human diseases are poorly characterized. This compromises data analysis. To infer the immunoglobulin genes of BALB/c mice, we used long-read SMRT s
Externí odkaz:
https://doaj.org/article/622ded152c8546b1835641d908b2d213
Publikováno v:
Frontiers in Allergy, Vol 3 (2022)
Allergic diseases affect many individuals world-wide and are dependent on the interaction between allergens and antibodies of the IgE isotype. Allergen-specific immunotherapy (AIT) can alter the development of the disease, e.g., through induction of
Externí odkaz:
https://doaj.org/article/3fe698ed771547cbafc0903bb1348bc8
Autor:
Wael Bahnan, Sebastian Wrighton, Martin Sundwall, Anna Bläckberg, Olivia Larsson, Urban Höglund, Hamed Khakzad, Magdalena Godzwon, Maria Walle, Elisabeth Elder, Anna Söderlund Strand, Lotta Happonen, Oscar André, Johannes Kumra Ahnlide, Thomas Hellmark, Vidar Wendel-Hansen, Robert PA. Wallin, Johan Malmstöm, Lars Malmström, Mats Ohlin, Magnus Rasmussen, Pontus Nordenfelt
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Spike-specific antibodies are central to effective COVID19 immunity. Research efforts have focused on antibodies that neutralize the ACE2-Spike interaction but not on non-neutralizing antibodies. Antibody-dependent phagocytosis is an immune mechanism
Externí odkaz:
https://doaj.org/article/f92905abfadc4d269db7f2ae1d052963
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Upstream and downstream sequences of immunoglobulin genes may affect the expression of such genes. However, these sequences are rarely studied or characterized in most studies of immunoglobulin repertoires. Inference from large, rearranged immunoglob
Externí odkaz:
https://doaj.org/article/a6a477ab079c41aa80e1d2208af56e47