Triple blockade of EGFR, MEK and PD-L1 has antitumor activity in colorectal cancer models with constitutive activation of MAPK signaling and PD-L1 overexpression.

Autor: Napolitano, S.^1,2 (AUTHOR), Matrone, N.^1,3 (AUTHOR), Muddassir, A. L.² (AUTHOR), Martini, G.^1,4 (AUTHOR), Sorokin, A.² (AUTHOR), De Falco, V.¹ (AUTHOR), Giunta, E. F.¹ (AUTHOR), Ciardiello, D.¹ (AUTHOR), Martinelli, E.¹ (AUTHOR), Belli, V.¹ (AUTHOR), Furia, M.⁵ (AUTHOR), Kopetz, S.² (AUTHOR), Morgillo, F.¹ (AUTHOR), Ciardiello, F.¹ (AUTHOR), Troiani, T.¹ (AUTHOR) teresa.troiani@unicampania.it

Publikováno v: Journal of Experimental & Clinical Cancer Research (17569966). 12/16/2019, Vol. 38 Issue 1, p1-18. 18p.

AXL is a predictor of poor survival and of resistance to anti-EGFR therapy in RAS wild-type metastatic colorectal cancer

Autor: Cardone C., Blauensteiner B., Moreno-Viedma V., Martini G., Simeon V., Vitiello P. P., Ciardiello D., Belli V., Matrone N., Troiani T., Morgillo F., Zito Marino F., Dentice M., Nappi A., Boccaccino A., Antoniotti C., Cremolini C., Pietrantonio F., Prager G. W., Normanno N., Maiello E., Argiles G., Elez E., Signoriello G., Franco R., Falcone A., Tabernero J., Sibilia M., Ciardiello F., Martinelli E., ZITO MARINO, Federica

Background RAS mutations are the only validated biomarkers in metastatic colorectal cancer (mCRC) for anti-epidermal growth factor receptor (EGFR) therapy. Limited clinical information is available on AXL expression, marker of epithelial to mesenchym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4937b3b9337afc85a90006c6268b2a74
https://hdl.handle.net/11588/920571

Dual inhibition of TGFβ and AXL as a novel therapy for human colorectal adenocarcinoma with mesenchymal phenotype.

Autor: Ciardiello D; Medical Oncology, Department of Precision Medicine, Università Degli Studi Della Campania Luigi Vanvitelli, Napoli, Campania, Italy., Blauensteiner B; Department of Medicine I, Comprehensive Cancer Center, Research, Medical University of Vienna, Vienna, Austria., Matrone N; Medical Oncology, Department of Precision Medicine, Università Degli Studi Della Campania Luigi Vanvitelli, Napoli, Campania, Italy.; Department of Medicine I, Comprehensive Cancer Center, Research, Medical University of Vienna, Vienna, Austria., Belli V; Medical Oncology, Department of Precision Medicine, Università Degli Studi Della Campania Luigi Vanvitelli, Napoli, Campania, Italy., Mohr T; Department of Medicine I, Comprehensive Cancer Center, Research, Medical University of Vienna, Vienna, Austria.; Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria., Vitiello PP; Medical Oncology, Department of Precision Medicine, Università Degli Studi Della Campania Luigi Vanvitelli, Napoli, Campania, Italy., Martini G; Medical Oncology, Department of Precision Medicine, Università Degli Studi Della Campania Luigi Vanvitelli, Napoli, Campania, Italy., Poliero L; Medical Oncology, Department of Precision Medicine, Università Degli Studi Della Campania Luigi Vanvitelli, Napoli, Campania, Italy., Cardone C; Medical Oncology, Department of Precision Medicine, Università Degli Studi Della Campania Luigi Vanvitelli, Napoli, Campania, Italy., Napolitano S; Medical Oncology, Department of Precision Medicine, Università Degli Studi Della Campania Luigi Vanvitelli, Napoli, Campania, Italy., De Falco V; Medical Oncology, Department of Precision Medicine, Università Degli Studi Della Campania Luigi Vanvitelli, Napoli, Campania, Italy., Giunta EF; Medical Oncology, Department of Precision Medicine, Università Degli Studi Della Campania Luigi Vanvitelli, Napoli, Campania, Italy., Ciaramella V; Medical Oncology, Department of Precision Medicine, Università Degli Studi Della Campania Luigi Vanvitelli, Napoli, Campania, Italy., Corte CD; Medical Oncology, Department of Precision Medicine, Università Degli Studi Della Campania Luigi Vanvitelli, Napoli, Campania, Italy., Barra G; Medical Oncology, Department of Precision Medicine, Università Degli Studi Della Campania Luigi Vanvitelli, Napoli, Campania, Italy., Selvaggi F; General and Oncologic Surgery, Department of Medical, Surgical, Neurologic, Metabolic and Ageing Sciences, Università Degli Studi Della Campania Luigi Vanvitelli, Napoli, Campania, Italy., Franco R; Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, Università Degli Studi Della Campania Luigi Vanvitelli, Napoli, Campania, Italy., Marino FZ; Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, Università Degli Studi Della Campania Luigi Vanvitelli, Napoli, Campania, Italy., Cuomo A; Gastroenterology Unit, Ospedale Umberto I, Nocera Inferiore, Italy., Morgillo F; Medical Oncology, Department of Precision Medicine, Università Degli Studi Della Campania Luigi Vanvitelli, Napoli, Campania, Italy., Troiani T; Medical Oncology, Department of Precision Medicine, Università Degli Studi Della Campania Luigi Vanvitelli, Napoli, Campania, Italy., Sibilia M; Department of Medicine I, Comprehensive Cancer Center, Research, Medical University of Vienna, Vienna, Austria., Ciardiello F; Medical Oncology, Department of Precision Medicine, Università Degli Studi Della Campania Luigi Vanvitelli, Napoli, Campania, Italy., Martinelli E; Medical Oncology, Department of Precision Medicine, Università Degli Studi Della Campania Luigi Vanvitelli, Napoli, Campania, Italy. erikamartinelli@yahoo.it.

Publikováno v: Medical oncology (Northwood, London, England) [Med Oncol] 2021 Feb 11; Vol. 38 (3), pp. 24. Date of Electronic Publication: 2021 Feb 11.

66P - Dual inhibition of TGF-β and AXL as a novel treatment for colorectal cancer

Autor: Ciardiello, D., Belli, V., Cardone, C., Vitiello, P.P., Martini, G., Poliero, L., Borrelli, C., Arrichiello, G., Ciaramella, V., Matrone, N., Barra, G., De Falco, V., Giunta, E.F., Morgillo, F., Troiani, T., Terminiello, M., Melisi, D., Ciardiello, F., Martinelli, E.

Publikováno v: In Annals of Oncology October 2019 30 Supplement 5:v18-v19

AXL is a predictor of poor survival and of resistance to anti-EGFR therapy in RAS wild-type metastatic colorectal cancer.

Autor: Cardone C; Department of Precision Medicine, Università Degli Studi Della Campania 'Luigi Vanvitelli', Naples, Italy. Electronic address: cardone.cla@gmail.com., Blauensteiner B; Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Wien, Austria., Moreno-Viedma V; Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Wien, Austria., Martini G; Department of Precision Medicine, Università Degli Studi Della Campania 'Luigi Vanvitelli', Naples, Italy., Simeon V; Department of Public, Clinical and Preventive Medicine, Medical Statistics Unit, Università Degli Studi Della Campania 'Luigi Vanvitelli', Naples, Italy., Vitiello PP; Department of Precision Medicine, Università Degli Studi Della Campania 'Luigi Vanvitelli', Naples, Italy., Ciardiello D; Department of Precision Medicine, Università Degli Studi Della Campania 'Luigi Vanvitelli', Naples, Italy., Belli V; Department of Precision Medicine, Università Degli Studi Della Campania 'Luigi Vanvitelli', Naples, Italy., Matrone N; Department of Precision Medicine, Università Degli Studi Della Campania 'Luigi Vanvitelli', Naples, Italy., Troiani T; Department of Precision Medicine, Università Degli Studi Della Campania 'Luigi Vanvitelli', Naples, Italy., Morgillo F; Department of Precision Medicine, Università Degli Studi Della Campania 'Luigi Vanvitelli', Naples, Italy., Zito Marino F; Pathology Unit, Università Degli Studi Della Campania 'Luigi Vanvitelli', Naples, Italy., Dentice M; Department of Clinical Medicine and Surgery, University of Naples 'Federico II', Naples, Italy., Nappi A; Department of Public Health, University of Naples 'Federico II', Naples, Italy., Boccaccino A; Department of Translational Research and New Technologies in Medicine and Surgery, Unit of Medical Oncology, Azienda Ospedaliero-Universitaria Pisana, University of Pisa, Pisa, Italy., Antoniotti C; Department of Translational Research and New Technologies in Medicine and Surgery, Unit of Medical Oncology, Azienda Ospedaliero-Universitaria Pisana, University of Pisa, Pisa, Italy., Cremolini C; Department of Translational Research and New Technologies in Medicine and Surgery, Unit of Medical Oncology, Azienda Ospedaliero-Universitaria Pisana, University of Pisa, Pisa, Italy., Pietrantonio F; Fondazione IRCCS Istituto Nazionale Dei Tumori, Università di Milano, Milan, Italy., Prager GW; Department of Medicine I, Division of Oncology, Medical University of Vienna, Wien, Austria., Normanno N; Cell Biology and Biotherapy Unit, Istituto Nazionale Tumori 'Fondazione G. Pascale'-IRCCS, Naples, Italy., Maiello E; Department of Oncology and Hematology, Foundation IRCCS 'Casa Sollievo Della Sofferenza', San Giovanni Rotondo, Italy., Argiles G; Vall D'Hebron University Hospital (HUVH) and Vall D'Hebron Institute of Oncology (VHIO), UVic-UCC, IOB-Quiron, Barcelona, Spain., Elez E; Vall D'Hebron University Hospital (HUVH) and Vall D'Hebron Institute of Oncology (VHIO), UVic-UCC, IOB-Quiron, Barcelona, Spain., Signoriello G; Department of Public, Clinical and Preventive Medicine, Medical Statistics Unit, Università Degli Studi Della Campania 'Luigi Vanvitelli', Naples, Italy., Franco R; Pathology Unit, Università Degli Studi Della Campania 'Luigi Vanvitelli', Naples, Italy., Falcone A; Department of Translational Research and New Technologies in Medicine and Surgery, Unit of Medical Oncology, Azienda Ospedaliero-Universitaria Pisana, University of Pisa, Pisa, Italy., Tabernero J; Vall D'Hebron University Hospital (HUVH) and Vall D'Hebron Institute of Oncology (VHIO), UVic-UCC, IOB-Quiron, Barcelona, Spain., Sibilia M; Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Wien, Austria., Ciardiello F; Department of Precision Medicine, Università Degli Studi Della Campania 'Luigi Vanvitelli', Naples, Italy., Martinelli E; Department of Precision Medicine, Università Degli Studi Della Campania 'Luigi Vanvitelli', Naples, Italy. Electronic address: erika.martinelli@unicampania.it.

Publikováno v: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2020 Oct; Vol. 138, pp. 1-10. Date of Electronic Publication: 2020 Aug 17.