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Marine Collagen Hydrolysates Downregulate the Synthesis of Pro-Catabolic and Pro-Inflammatory Markers of Osteoarthritis and Favor Collagen Production and Metabolic Activity in Equine Articular Chondrocyte Organoids

Autor: Bastien Bourdon, Romain Contentin, Frédéric Cassé, Chloé Maspimby, Sarah Oddoux, Antoine Noël, Florence Legendre, Nicolas Gruchy, Philippe Galéra

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 2, p 580 (2021)

Articular cartilage experiences mechanical constraints leading to chondral defects that inevitably evolve into osteoarthritis (OA), because cartilage has poor intrinsic repair capacity. Although OA is an incurable degenerative disease, several dietar

Externí odkaz: https://doaj.org/article/f97547555af34ff0b2560a5e33ae2738

RNA Interference and BMP-2 Stimulation Allows Equine Chondrocytes Redifferentiation in 3D-Hypoxia Cell Culture Model: Application for Matrix-Induced Autologous Chondrocyte Implantation

Autor: Rodolphe Rakic, Bastien Bourdon, Magalie Hervieu, Thomas Branly, Florence Legendre, Nathalie Saulnier, Fabrice Audigié, Stéphane Maddens, Magali Demoor, Philippe Galera

Publikováno v: International Journal of Molecular Sciences, Vol 18, Iss 9, p 1842 (2017)

As in humans, osteoarthritis (OA) causes considerable economic loss to the equine industry. New hopes for cartilage repair have emerged with the matrix-associated autologous chondrocyte implantation (MACI). Nevertheless, its limitation is due to the

Externí odkaz: https://doaj.org/article/da1c9377fbc04344b14c5bcb8d622761

Marine Collagen Hydrolysates Promote Collagen Synthesis, Viability and Proliferation While Downregulating the Synthesis of Pro-Catabolic Markers in Human Articular Chondrocytes

Autor: Bourdon, Bastien, Cassé, Frédéric, Gruchy, Nicolas, Cambier, Pierre, Leclercq, Sylvain, Oddoux, Sarah, Noël, Antoine, Lafont, Jérôme, Contentin, Romain, Galéra, Philippe

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 7
International Journal of Molecular Sciences, MDPI, 2021, 22 (7), pp.3693-3718. ⟨10.3390/ijms22073693⟩
International Journal of Molecular Sciences, Vol 22, Iss 3693, p 3693 (2021)

Cartilage is a non-innervated and non-vascularized tissue. It is composed of one main cell type, the chondrocyte, which governs homeostasis within the cartilage tissue, but has low metabolic activity. Articular cartilage undergoes substantial stresse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::73f46a241652fdeebe4b2fe8ac9d8f5b
https://pubmed.ncbi.nlm.nih.gov/33916312

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