Zobrazeno 1 - 10
of 586
pro vyhledávání: '"Matrisome"'
Autor:
Santhanasabapathy Rajasekaran, Siyuan Cheng, Nithya Gajendran, Sahar Shekoohi, Liudmila Chesnokova, Xiuping Yu, Stephan N. Witt
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The Parkinson’s disease protein, alpha-synuclein (α-syn/SNCA), is highly expressed in neurons and melanomas. The goal of this study was to reveal the mechanism(s) of α-syn’s involvement in melanoma pathogenesis. To decipher the genes a
Externí odkaz:
https://doaj.org/article/e0b3c8a4780b4b5f8952b79fd5412b48
Autor:
Inha Baek, Younghye Song
Publikováno v:
Matrix Biology Plus, Vol 24, Iss , Pp 100165- (2024)
Traumatic spinal cord injury (SCI) induces permanent sensorimotor deficit below the site of injury. There is various research conducted to provide effective therapy, however, SCI is still considered incurable due to the complex nature of the injury s
Externí odkaz:
https://doaj.org/article/77e123c327134a49a4fc1018b8ef8a1a
Autor:
Pattarawan Pattamaprapanont, Eileen M. Cooney, Tara L. MacDonald, Joao A. Paulo, Hui Pan, Jonathan M. Dreyfuss, Sarah J. Lessard
Publikováno v:
Matrix Biology Plus, Vol 23, Iss , Pp 100159- (2024)
Skeletal muscle has a unique ability to remodel in response to stimuli such as contraction and aerobic exercise training. Phenotypic changes in muscle that occur with training such as a switch to a more oxidative fiber type, and increased capillary d
Externí odkaz:
https://doaj.org/article/37f49428b788458294966f8f3bd9d9c4
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The excessive deposition and cross-linking of core matrisome components typically result in abnormal remodeling of the extracellular matrix (ECM), leading to increased liver stiffness and worsening liver fibrosis. Exploring the biochemical properties
Externí odkaz:
https://doaj.org/article/f6a24834a5004dcfb5ab65f4ad602f67
Autor:
Jean Lucas Kremer, Henrique Sanchez Ortega, Talita Souza-Siqueira, Claudia Blanes Angeli, Leo Kei Iwai, Giuseppe Palmisano, Claudimara Ferini Pacicco Lotfi
Publikováno v:
Matrix Biology Plus, Vol 23, Iss , Pp 100158- (2024)
The extracellular matrix (ECM) comprises macromolecules that shape a complex three-dimensional network. Filling the intercellular space and playing a crucial role in the structure and function of tissues, ECM regulates essential cellular processes su
Externí odkaz:
https://doaj.org/article/847cc1a4bbc244668d73e4f6ea1b51f3
The extracellular matrix component perlecan/HSPG2 regulates radioresistance in prostate cancer cells
Autor:
Ivana Samaržija, Vasyl Lukiyanchuk, Marija Lončarić, Anja Rac-Justament, Nikolina Stojanović, Ielizaveta Gorodetska, Uğur Kahya, Jonathan D. Humphries, Mahak Fatima, Martin J. Humphries, Ana Fröbe, Anna Dubrovska, Andreja Ambriović-Ristov
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Radiotherapy of prostate cancer (PC) can lead to the acquisition of radioresistance through molecular mechanisms that involve, in part, cell adhesion-mediated signaling. To define these mechanisms, we employed a DU145 PC model to conduct a comparativ
Externí odkaz:
https://doaj.org/article/1313c7d198bb45ab93487b56f75e5c06
Autor:
Joshua A. Rich, Yu Fan, Qingrong Chen, Daoud Meerzaman, William G. Stetler-Stevenson, David Peeney
Publikováno v:
Matrix Biology Plus, Vol 23, Iss , Pp 100156- (2024)
Extracellular matrix remodeling is a hallmark of tissue development, homeostasis, and disease. The processes that mediate remodeling, and the consequences of such, are the topic of extensive focus in biomedical research. Cell culture methods represen
Externí odkaz:
https://doaj.org/article/1235e98ca2644becb6e250eb49a4e94d
Autor:
Yasuteru Inoue, Yingxue Ren, Shuwen Zhang, Michael Bamkole, Naeyma N. Islam, Manikandan Selvaraj, Wenyan Lu, Thomas R. Caulfield, Yonghe Li, Takahisa Kanekiyo
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
The maturation of brain microvascular endothelial cells leads to the formation of a tightly sealed monolayer, known as the blood–brain barrier (BBB). The BBB damage is associated with the pathogenesis of age-related neurodegenerative diseases inclu
Externí odkaz:
https://doaj.org/article/044332bc5f914607b440f788e2c9c05e
Autor:
Alessandro Mancini, Maria Teresa Gentile, Francesca Pentimalli, Salvatore Cortellino, Michele Grieco, Antonio Giordano
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
The biophysical and biomechanical properties of the extracellular matrix (ECM) are crucial in the processes of cell differentiation and proliferation. However, it is unclear to what extent tumor cells are influenced by biomechanical and biophysical c
Externí odkaz:
https://doaj.org/article/57d8abfed09443db8a6a0110e266d64c
Autor:
Anna-Maria Diedrich, Assal Daneshgar, Peter Tang, Oliver Klein, Annika Mohr, Olachi A. Onwuegbuchulam, Sabine von Rueden, Kerstin Menck, Annalen Bleckmann, Mazen A. Juratli, Felix Becker, Igor M. Sauer, Karl H. Hillebrandt, Andreas Pascher, Benjamin Struecker
Publikováno v:
Journal of Biological Engineering, Vol 18, Iss 1, Pp 1-16 (2024)
Abstract Background The extracellular matrix (ECM) is a three-dimensional network of proteins that encases and supports cells within a tissue and promotes physiological and pathological cellular differentiation and functionality. Understanding the co
Externí odkaz:
https://doaj.org/article/184b7542c395420292ac63157f983099