Ruxolitinib in treatment-naive or corticosteroid-refractory paediatric patients with chronic graft-versus-host disease (REACH5): interim analysis of a single-arm, multicentre, phase 2 study.

Autor: Locatelli F; Department of Pediatric Hematology/Oncology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Catholic University of the Sacred Heart, Rome, Italy. Electronic address: franco.locatelli@opbg.net., Antmen B; Division of Pediatric Hematology and Oncology and Stem Cell Transplantation, Department of Pediatrics, Acıbadem Adana Hospital, Adana, Türkiye., Kang HJ; Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Cancer Research Institute, Seoul National University Children's Hospital, Seoul, South Korea., Koh K; Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan., Takahashi Y; Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan., Kupesiz A; Paediatric Hematology Oncology, Akdeniz University School of Medicine, Antalya, Türkiye., Dias Matos MGA; GRAACC, São Paulo, Brazil., Chopra Y; Division of Hematology/Oncology, The Hospital for Sick Children, The University of Toronto, Toronto, ON, Canada., Bhat S; Mazumdar Shaw Medical Center, Narayana Health City, Bangalore, India., Im HJ; Division of Pediatric Hematology/Oncology, Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, South Korea., Güngör T; Department of Hematology/Oncology/Immunology, Gene Therapy, and Stem Cell Transplantation, University Children's Hospital Zürich, Eleonore Foundation & Children's Research Center, Zurich, Switzerland., Lu MY; Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan., Stefanelli T; Novartis Pharma, Basel, Switzerland., Rosko C; Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA., St Pierre A; Novartis Pharma, Basel, Switzerland., Burock K; Novartis Pharma, Basel, Switzerland., Smith Y; Novartis Ireland Limited, Dublin, Ireland., Sinclair K; Novartis Pharma, Basel, Switzerland., Diaz-de-Heredia C; Division of Pediatric Hematology and Oncology and Stem Cell Transplantation, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca, Barcelona, Spain.

Publikováno v: The Lancet. Haematology [Lancet Haematol] 2024 Aug; Vol. 11 (8), pp. e580-e592. Date of Electronic Publication: 2024 Jul 10.