Use of a baseline risk score to identify the risk of serious infectious events in patients with rheumatoid arthritis during certolizumab pegol treatment

Autor: Jeffrey R. Curtis, Kevin Winthrop, Cathy O’Brien, Matladi N. Ndlovu, Marc de Longueville, Boulos Haraoui

Publikováno v: Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-12 (2017)

Abstract Background The risk of serious infectious events (SIEs) is increased in patients with rheumatoid arthritis (RA). The aim of this study was to develop an age-adjusted comorbidity index (AACI) to predict, using baseline characteristics, the SI

Externí odkaz: https://doaj.org/article/0106868340cd49c580c5910e21eb40cc

Supplementary Figure 2 from Attenuation of Mitogen- and Stress-Activated Protein Kinase-1–Driven Nuclear Factor-κB Gene Expression by Soy Isoflavones Does Not Require Estrogenic Activity

Autor: Guy Haegeman, Elke Boone, 'Matladi N. Ndlovu, Linda Vermeulen, Nathalie Dijsselbloem, Wim Vanden Berghe

Supplementary Figure 2 from Attenuation of Mitogen- and Stress-Activated Protein Kinase-1–Driven Nuclear Factor-κB Gene Expression by Soy Isoflavones Does Not Require Estrogenic Activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fec31ea8fca5e4f22a371845ab98b13
https://doi.org/10.1158/0008-5472.22366523

Use of a baseline risk score to identify the risk of serious infectious events in patients with rheumatoid arthritis during certolizumab pegol treatment

Autor: Boulos Haraoui, C. O'Brien, Marc de Longueville, Jeffrey R. Curtis, Matladi N. Ndlovu, Kevin L. Winthrop

Publikováno v: Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-12 (2017)
Arthritis Research & Therapy

The risk of serious infectious events (SIEs) is increased in patients with rheumatoid arthritis (RA). The aim of this study was to develop an age-adjusted comorbidity index (AACI) to predict, using baseline characteristics, the SIE risk in patients w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf3cf09c12707f09b481613a63c7c42
http://link.springer.com/article/10.1186/s13075-017-1466-y

The interplay between the lysine demethylase KDM1A and DNA methyltransferases in cancer cells is cell cycle dependent

Autor: Judith Luciani, Martin Bizet, Sarah Dedeurwaerder, Carmen Brenner, Eléonore Josseaux, Pascale Putmans, Pierre Francois Cartron, Matladi N. Ndlovu, François Fuks, Matthieu Defrance, Rachel Deplus, Emilie Calonne

Publikováno v: Oncotarget, 7 (37
Oncotarget
Oncotarget, 2016, [Epub ahead of print]. ⟨10.18632/oncotarget.10624⟩
Oncotarget, Impact journals, 2016, [Epub ahead of print]. ⟨10.18632/oncotarget.10624⟩

DNA methylation and histone modifications are key epigenetic regulators of gene expression, and tight connections are known between the two. DNA methyltransferases are upregulated in several tumors and aberrant DNA methylation profiles are a cancer h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea003dc3f739aec8e788d9ee913aeaf7
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/243793

Hyperactivated NF-κB and AP-1 Transcription Factors Promote Highly Accessible Chromatin and Constitutive Transcription across the Interleukin-6 Gene Promoter in Metastatic Breast Cancer Cells

Autor: Pieter Callebert, Wim Vanden Berghe, Guy Haegeman, Karlien Van Wesemael, Carine Van Lint, Matladi N. Ndlovu, Dany Chalbos

Publikováno v: Molecular and Cellular Biology. 29:5488-5504

Interleukin-6 (IL-6), involved in cancer-related inflammation, acts as an autocrine and paracrine growth factor, which promotes angiogenesis, metastasis, and subversion of immunity, and changes the response to hormones and to chemotherapeutics. We ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b4cb67af8e00eb7e537aaaa1dfb2aae
https://doi.org/10.1128/mcb.01657-08