Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Matjaz Rokavec"'
Publikováno v:
Cancer Communications, Vol 44, Iss 3, Pp 433-437 (2024)
Externí odkaz:
https://doaj.org/article/569443f5f1cf4b1088c6eb4c6dbe0c62
Publikováno v:
Cell Death and Disease, Vol 14, Iss 10, Pp 1-15 (2023)
Abstract Aspirin and its active metabolite salicylate have emerged as promising agents for the chemoprevention of colorectal cancer (CRC). Moreover, aspirin suppresses the progression of established CRCs. However, the underlying molecular mechanisms
Externí odkaz:
https://doaj.org/article/a440eda9d4ed4941b59a0243166880f9
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 267-274 (2023)
Members of the microRNA-34/miR-34 family are induced by the p53 tumor suppressor and themselves possess tumor suppressive properties, as they inhibit the translation of mRNAs that encode proteins involved in processes, such as proliferation, migratio
Externí odkaz:
https://doaj.org/article/d5d8dd8e78964b9e94392f88fd7392ed
Publikováno v:
Cancers, Vol 15, Iss 22, p 5316 (2023)
We have previously shown that the extracellular matrix and basement membrane protein Nidogen1 (NID1) is secreted by more malignant, mesenchymal-like CRC cells and induces the epithelial–mesenchymal transition (EMT) and promotes the migration and in
Externí odkaz:
https://doaj.org/article/0369146170184438991a991cef4be390
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-24 (2022)
Abstract Background AP4 (TFAP4) encodes a basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factor and is a direct target gene of the oncogenic transcription factor c-MYC. Here, we set out to determine the relevance of AP4 in human colore
Externí odkaz:
https://doaj.org/article/5ae01414ce1b46b9880768fe58ae7217
Autor:
Sophie L. Boos, Leon P. Loevenich, Sebastian Vosberg, Thomas Engleitner, Rupert Öllinger, Jörg Kumbrink, Matjaz Rokavec, Marlies Michl, Philipp A. Greif, Andreas Jung, Heiko Hermeking, Jens Neumann, Thomas Kirchner, Roland Rad, Peter Jung
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 517-540 (2022)
Background & Aims: Patient-derived tumor organoids recapitulate the characteristics of colorectal cancer (CRC) and provide an ideal platform for preclinical evaluation of personalized treatment options. We aimed to model the acquisition of chemotoler
Externí odkaz:
https://doaj.org/article/916bf465e7144cfd8d6002ff3bbfa24f
Publikováno v:
Cancers, Vol 15, Iss 4, p 1143 (2023)
Tumor-associated hypoxia, i.e., decreased availability of oxygen, results in a poor clinical outcome since it promotes EMT, metastasis, and chemotherapy-resistance. We have previously identified p53 and its target miR-34a, as critical determinants of
Externí odkaz:
https://doaj.org/article/cb30329b03404a898969e95d88397b9d
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 391-418 (2020)
Background & Aims: The miR-34a gene is a direct target of p53 and is commonly silenced in colorectal cancer (CRC). Here we identified the receptor tyrosine kinase CSF1R as a direct miR-34a target and characterized CSF1R as an effector of p53/miR-34a-
Externí odkaz:
https://doaj.org/article/52278c3e5115469e9f3f4a23f8d6d48f
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 783-802 (2019)
Background & Aims: Intratumor heterogeneity is a common feature of colorectal cancer (CRC). Here, we analyzed whether mesenchymal-like CRC cells promote the progression of epithelial-like CRC cells via paracrine mechanisms. Methods: Six CRC cell line
Externí odkaz:
https://doaj.org/article/061c115ca9e34c9a89bb891303607278
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Epithelial-mesenchymal transition (EMT) plays an important role in tumor invasion and metastasis. A comprehensive, bioinformatics analysis of CCLE and TCGA datasets of seven tumor types allowed us to identify a novel pan-cancer EMT-associate
Externí odkaz:
https://doaj.org/article/688cc78b6434435a850ee3cdf62c3d60