Zobrazeno 1 - 10 of 61 pro vyhledávání: '"Matjaz Humar"'
1
Akademický článek
Disease relevant modifications of the methylome and transcriptome by particulate matter (PM2.5) from biomass combustion
Autor: Katharina Heßelbach, Gwang-Jin Kim, Stephan Flemming, Thomas Häupl, Marc Bonin, Regina Dornhof, Stefan Günther, Irmgard Merfort, Matjaz Humar
Publikováno v: Epigenetics, Vol 12, Iss 9, Pp 779-792 (2017)
Exposure to particulate matter (PM) is recognized as a major health hazard, but molecular responses are still insufficiently described. We analyzed the epigenetic impact of ambient PM2.5 from biomass combustion on the methylome of primary human bronc
Externí odkaz: https://doaj.org/article/8f1e8d78df7b4ba88c84458248d5fa03
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2
Akademický článek
Stress fibers, autophagy and necrosis by persistent exposure to PM2.5 from biomass combustion.
Autor: Regina Dornhof, Christoph Maschowski, Anastasiya Osipova, Reto Gieré, Maximilian Seidl, Irmgard Merfort, Matjaz Humar
Publikováno v: PLoS ONE, Vol 12, Iss 7, p e0180291 (2017)
Fine particulate matter (PM2.5) can adversely affect human health. Emissions from residential energy sources have the largest impact on premature mortality globally, but their pathological and molecular implications on cellular physiology are still e
Externí odkaz: https://doaj.org/article/7e5e072ba5a34cbab7a168c830f558fc
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3
Akademický článek
Interleukin-1β enhances FasL-induced caspase-3/-7 activity without increasing apoptosis in primary mouse hepatocytes.
Autor: Anna Lutz, Julia Sanwald, Maria Thomas, Ronny Feuer, Oliver Sawodny, Michael Ederer, Christoph Borner, Matjaz Humar, Irmgard Merfort
Publikováno v: PLoS ONE, Vol 9, Iss 12, p e115603 (2014)
Sustained inflammation may increase the susceptibility of hepatocytes to apoptotic cell death and therefore exacerbate liver damage. Here we report that the pro-inflammatory cytokine IL-1β sensitizes primary murine hepatocytes to Fas ligand (FasL)-i
Externí odkaz: https://doaj.org/article/4908eb02b14246939f59450311aadd9e
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4
Akademický článek
Thiopental inhibits global protein synthesis by repression of eukaryotic elongation factor 2 and protects from hypoxic neuronal cell death.
Autor: Christian I Schwer, Cornelius Lehane, Timo Guelzow, Simone Zenker, Karl M Strosing, Sashko Spassov, Anika Erxleben, Bernd Heimrich, Hartmut Buerkle, Matjaz Humar
Publikováno v: PLoS ONE, Vol 8, Iss 10, p e77258 (2013)
Ischemic and traumatic brain injury is associated with increased risk for death and disability. The inhibition of penumbral tissue damage has been recognized as a target for therapeutic intervention, because cellular injury evolves progressively upon
Externí odkaz: https://doaj.org/article/823258f309044594819056d4c582d633
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5
Akademický článek
Isolation of Flavonoids from Deguelia duckeana and Their Effect on Cellular Viability, AMPK, eEF2, eIF2 and eIF4E
Autor: Lorena M. C. Cursino, Nerilson M. Lima, Renato Murillo, Cecilia V. Nunez, Irmgard Merfort, Matjaz Humar
Publikováno v: Molecules, Vol 21, Iss 2, p 192 (2016)
Preparations of Deguelia duckeana, known in Brazil as timbó, are used by indigenous people to kill fish. Reinvestigation of its extracts resulted in the isolation and identification of 11 known flavonoids identified as 3,5,4’-trimethoxy-4-prenylst
Externí odkaz: https://doaj.org/article/239bb51e1a9c485aadf7c2a48c213f99
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6
Particulate Matter (PM2.5) from Biomass Combustion Induces an Anti-Oxidative Response and Cancer Drug Resistance in Human Bronchial Epithelial BEAS-2B Cells
Autor: Matjaz Humar, Irmgard Merfort, Anastasiya Osipova, Wolfgang Schmidt-Heck, Alfonso García Piñeres, Désirée Popadić, Stefan Günther, Katharina Heßelbach, Gwang-Jin Kim, Regina Merk
Publikováno v: International Journal of Environmental Research and Public Health, Vol 17, Iss 8193, p 8193 (2020)
International Journal of Environmental Research and Public Health
Volume 17
Issue 21
Nearly half of the world&rsquo
s population relies on combustion of solid biofuels to cover fundamental energy demands. Epidemiologic data demonstrate that particularly long-term emissions adversely affect human health. However, pathological mol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d7d2e918617db95f5ec75ec4a5d09e7
https://www.mdpi.com/1660-4601/17/21/8193
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7
Gene expression profiling of human bronchial epithelial cells exposed to fine particulate matter (PM 2.5 ) from biomass combustion
Autor: Gwang-Jin Kim, Thomas Häupl, Sigrid Richter-Brockmann, Matjaz Humar, Stephan Flemming, Désirée Popadić, Marc Bonin, Katharina Heßelbach, Irmgard Merfort, Stefan Günther, Christine Achten, Regina Dornhof, Wolfgang Schmidt-Heck
Publikováno v: Toxicology and Applied Pharmacology. 347:10-22
One-third of the world's population relies on solid biomass fuels for domestic energy demands. In contrast to industrial or traffic related emissions, only a limited number of studies focus on the adverse health effects of particulate matter (PM) fro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b0f4f874dfe1db4f1b0233bb06523bf
https://doi.org/10.1016/j.taap.2018.03.024
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8
Bifunctional Duocarmycin Analogues as Inhibitors of Protein Tyrosine Kinases
Autor: Wolfgang Heydenreuter, Matjaz Humar, Lutz F. Tietze, Alexander Kreft, Stephan A. Sieber, Irmgard Merfort, Mehrnoush Kangani, Christian De Ford, Kamala Penchalaiah
Publikováno v: Journal of natural products. 82(1)
Bifunctional duocarmycin analogues are highly cytotoxic compounds that have been shown to be irreversible aldehyde dehydrogenase 1 inhibitors. Interestingly, cells with low aldehyde dehydrogenase 1 expression are also sensitive to bifunctional duocar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6ec276b0f6e38e71d0002a076eae94
https://pubmed.ncbi.nlm.nih.gov/30620194
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10
Implantable Waveguides for Deep-Tissue Photoactivation
Autor: Ki Su Kim, Malte C. Gather, Myunghwan Choi, Mark Randolph, Robert W. Redmond, Seok-Hyun Yun, Matjaz Humar, Sedat Nizamoglu, Seonghoon Kim, Giuliano Scarcelli, Sei Kwang Hahn
Publikováno v: Advanced Photonics 2017 (IPR, NOMA, Sensors, Networks, SPPCom, PS).
We demonstrated biopolymer waveguides that are gradually resorbed by the tissue and used them for wound closure. The waveguides enabled a 10-fold extension of the photoactivated tissue area in comparision with conventional photochemical bonding.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4206bd0d3f8bfa99ee4835d7bbf1bf31
https://doi.org/10.1364/noma.2017.noth1c.2
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