Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Matjaž Weiss"'
1
Akademický článek
New Quinolinone O-GlcNAc Transferase Inhibitors Based on Fragment Growth
Autor: Matjaž Weiss, Elena M. Loi, Maša Sterle, Cyril Balsollier, Tihomir Tomašič, Roland J. Pieters, Martina Gobec, Marko Anderluh
Publikováno v: Frontiers in Chemistry, Vol 9 (2021)
O-GlcNAcylation is an important post-translational and metabolic process in cells that must be carefully regulated. O-GlcNAc transferase (OGT) is ubiquitously present in cells and is the only enzyme that catalyzes the transfer of O-GlcNAc to proteins
Externí odkaz: https://doaj.org/article/bed20003ff6f4e85991d320f8a84b5ec
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2
Akademický článek
Discovery of a New Drug-like Series of OGT Inhibitors by Virtual Screening
Autor: Elena M. Loi, Tihomir Tomašič, Cyril Balsollier, Kevin van Eekelen, Matjaž Weiss, Martina Gobec, Matthew G. Alteen, David J. Vocadlo, Roland J. Pieters, Marko Anderluh
Publikováno v: Molecules, Vol 27, Iss 6, p 1996 (2022)
O-GlcNAcylation is an essential post-translational modification installed by the enzyme O-β-N-acetyl-d-glucosaminyl transferase (OGT). Modulating this enzyme would be extremely valuable to better understand its role in the development of serious hum
Externí odkaz: https://doaj.org/article/1b1043771f784525879d5b2d7670a274
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3
Akademický článek
Inhibition of O-GlcNAc Transferase Alters the Differentiation and Maturation Process of Human Monocyte Derived Dendritic Cells
Autor: Matjaž Weiss, Marko Anderluh, Martina Gobec
Publikováno v: Cells, Vol 10, Iss 12, p 3312 (2021)
The O-GlcNAcylation is a posttranslational modification of proteins regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase. These enzymes regulate the development, proliferation and function of cells, including the immune cells. Herein, we focused o
Externí odkaz: https://doaj.org/article/0e5f3da796b948ec9dd1a3c07211b04a
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4
Akademický článek
A Fine-Tuned Lipophilicity/Hydrophilicity Ratio Governs Antibacterial Potency and Selectivity of Bifurcated Halogen Bond-Forming NBTIs
Autor: Anja Kolarič, Maja Kokot, Martina Hrast, Matjaž Weiss, Irena Zdovc, Jurij Trontelj, Simon Žakelj, Marko Anderluh, Nikola Minovski
Publikováno v: Antibiotics, Vol 10, Iss 7, p 862 (2021)
Herein, we report the design of a focused library of novel bacterial topoisomerase inhibitors (NBTIs) based on innovative mainly monocyclic right-hand side fragments active against DNA gyrase and Topo IV. They exhibit a very potent and wide range of
Externí odkaz: https://doaj.org/article/3a9be81a740c4e36be2d85de170b35dd
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5
Akademický článek
Intracellular Hydrolysis of Small-Molecule O-Linked N-Acetylglucosamine Transferase Inhibitors Differs among Cells and Is Not Required for Its Inhibition
Autor: Elena Maria Loi, Matjaž Weiss, Stane Pajk, Martina Gobec, Tihomir Tomašič, Roland J. Pieters, Marko Anderluh
Publikováno v: Molecules, Vol 25, Iss 15, p 3381 (2020)
O-GlcNAcylation is an essential post-translational modification that occurs on nuclear and cytoplasmic proteins, regulating their function in response to cellular stress and altered nutrient availability. O-GlcNAc transferase (OGT) is the enzyme that
Externí odkaz: https://doaj.org/article/56e7fb03ea994e22adf0d0f79bb2e463
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6
Amide containing NBTI antibacterials with reduced hERG inhibition, retained antimicrobial activity against gram-positive bacteria and in vivo efficacy
Autor: Maja Kokot, Matjaž Weiss, Irena Zdovc, Lidija Senerovic, Natasa Radakovic, Marko Anderluh, Nikola Minovski, Martina Hrast
Publikováno v: European journal of medicinal chemistry, str. 1-13 : Ilustr., Vol. 250, 2023
COBISS-ID: 25429760
European journal of medicinal chemistry, vol. 115160, no. 250, pp. 1-13, 2023.
Novel bacterial topoisomerase inhibitors (NBTIs) are new promising antimicrobials for the treatment of multidrug-resistant bacterial infections. In recent years, many new NBTIs have been discovered, however most of them struggle with the same issue -
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007423b60ee74c7daa799df830c48ced
https://plus.cobiss.net/cobiss/si/en/bib/141418755
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7
Diminishing hERG inhibitory activity of aminopiperidine-naphthyridine linked NBTI antibacterials by structural and physicochemical optimizations
Autor: Maja Kokot, Matjaž Weiss, Irena Zdovc, Marko Anderluh, Martina Hrast, Nikola Minovski
Publikováno v: Bioorganic chemistry, 14 str. : Ilustr., Vol. 128, 2022
COBISS-ID: 25099008
Novel bacterial topoisomerase inhibitors (NBTIs) are an important new class of antibacterials targeting bacterial type II topoisomerases (DNA gyrase and topoisomerase IV). Notwithstanding their potent antibacterial activity, they suffer from a detrim
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea45b9f7b6861a73b519bc61b6d510d
https://www.sciencedirect.com/science/article/pii/S004520682200493X
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8
Covalently Conjugated NOD2/TLR7 Agonists Are Potent and Versatile Immune Potentiators
Autor: Samo Guzelj, Matjaž Weiss, Bram Slütter, Ruža Frkanec, Žiga Jakopin
Publikováno v: Journal of medicinal chemistry, vol. 65, no. 22, 2022.
The success of vaccination with subunit vaccines often relies on the careful choice of adjuvants. There is great interest in developing new adjuvants that can elicit a cellular immune response. Here, we address this challenge by taking advantage of t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18194c72251711e441e4351ebccd8203
https://www.bib.irb.hr/1266008
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9
Inhibition of O-GlcNAc Transferase Alters the Differentiation and Maturation Process of Human Monocyte Derived Dendritic Cells
Autor: Marko Anderluh, Martina Gobec, Matjaž Weiss
Publikováno v: Cells; Volume 10; Issue 12; Pages: 3312
Cells
Cells, str. 1-16 : Ilustr.; Vol. 10, iss. 12, [article no.] 3312, 2021
COBISS-ID: 519958809
Cells, vol. 10, no. 12, 3312, 2021.
Cells, Vol 10, Iss 3312, p 3312 (2021)
The O-GlcNAcylation is a posttranslational modification of proteins regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase. These enzymes regulate the development, proliferation and function of cells, including the immune cells. Herein, we focused o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57c8f4098d1dc99dcf478dac490295a2
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10
A Fine-Tuned Lipophilicity/Hydrophilicity Ratio Governs Antibacterial Potency and Selectivity of Bifurcated Halogen Bond-Forming NBTIs
Autor: Irena Zdovc, Matjaž Weiss, Marko Anderluh, Anja Kolarič, Simon Žakelj, Martina Hrast, Jurij Trontelj, Maja Kokot, Nikola Minovski
Publikováno v: Antibiotics
Volume 10
Issue 7
Antibiotics, 30 str. : Ilustr., tabele, Vol. 10, no. 7, art. 862, 2021
COBISS-ID: 522975769
Antibiotics, Vol 10, Iss 862, p 862 (2021)
Antibiotics, vol. 10, no. 7, 862, 2021.
Herein, we report the design of a focused library of novel bacterial topoisomerase inhibitors (NBTIs) based on innovative mainly monocyclic right-hand side fragments active against DNA gyrase and Topo IV. They exhibit a very potent and wide range of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8632f7f4df71c8f22b3f78dfee3d476
Zobrazit plný text záznamu

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