Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Matilde Arévalo Ruiz"'
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Abstract 4223: Cis-activation of PD-1+ effector T cells with dual-targeting immunocytokines generated using a novel chemical conjugation platform
Autor: Jean-Philippe Carralot, Matilde Arévalo Ruiz, Robert Tam, Eric Armentani, Vijaya R. Pattabiraman, Bertolt Kreft
Publikováno v: Cancer Research. 82:4223-4223
Immunocytokines (IC) provide the opportunity for targeted delivery of cytokines as payloads to tissues and cells to improve safety and efficacy of cytokine-based therapies. ICs have gained significant interest in recent years and several antibody-cyt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c2b2a398c985deaf63556fb9c6428f1
https://doi.org/10.1158/1538-7445.am2022-4223
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Abstract 2138: Creating next-generation biologics using a novel chemistry platform technology
Autor: Vijaya R. Pattabiraman, Matilde Arévalo Ruiz, Régis Boehringer, Benoit Hornsperger, Roy Meoded, Robert C. Tam, Bertolt Kreft
Publikováno v: Cancer Research. 82:2138-2138
Bright Peak Therapeutics is developing a portfolio of differentiated biotherapeutics using chemistry for applications in immuno-oncology and autoimmune diseases. Our unique chemical protein synthesis and engineering platform allows us to fine-tune cy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a68f4f148747db1ba6e822707eddf2cf
https://doi.org/10.1158/1538-7445.am2022-2138
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Abstract 4224: BPT-143: a fully synthetic alpha-dead IL-2 with a best-in-class preclinical pharmacodynamic and efficacy profile supporting first-in-human clinical development
Autor: Jean-Philippe Carralot, Rubén Alvarez Sanchez, Matilde Arévalo Ruiz, Magali Muller, Vijaya R. Pattabiraman, Bertolt Kreft
Publikováno v: Cancer Research. 82:4224-4224
High-dose recombinant IL-2 (aldesleukin) is approved for treatment of advanced melanoma and renal cell carcinoma, however, major limitations restrict its therapeutic use. Wild-type IL-2 acts via binding to the medium-affinity IL-2 receptor βγ (IL2R
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c528761b5dab2f0b5d7997890b646286
https://doi.org/10.1158/1538-7445.am2022-4224
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Symmetric and dissymmetric carbohydrate-phenyl ditriazole derivatives as DNA G-quadruplex ligands: Synthesis, biophysical studies and antiproliferative activity
Autor: Efres Belmonte-Reche, Juan Carlos Morales, Jean-Louis Mergny, Samir Amrane, Pablo Peñalver, Frédéric Rosu, Matilde Arévalo-Ruiz
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Here we present a novel G4-binding family of compounds based on a central core of phenyl ditriazole (PDTZ) modified with carbohydrates and phenyl pyrrolidinyl side-chains. Their synthesis was achieved using controlled click chemistry conditions to ob
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93998c49bf3ead202d78c26aedecbfc3
https://pubmed.ncbi.nlm.nih.gov/32229349
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G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents
Autor: Jose Juan Lopez-Rubio, Michela Zuffo, Juan Carlos Morales, Jean-Louis Mergny, Jenny Campos-Salinas, José M. Pérez-Victoria, Matilde Arévalo-Ruiz, Filippo Doria, Efres Belmonte-Reche, Marta Martínez-García, Mauro Freccero, Aurore Guédin, Marjorie Maynadier
Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (3), pp.1231-1240. ⟨10.1021/acs.jmedchem.7b01672⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
G-quadruplexes (G4) are DNA secondary structures that take part in the regulation of gene expression. Putative G4 forming sequences (PQS) have been reported in mammals, yeast, bacteria, and viruses. Here, we present PQS searches on the genomes of T.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b37134663c264709b225f4f349119ae
http://hdl.handle.net/10261/163518
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Synthesis, Binding Properties, and Differences in Cell Uptake of G-Quadruplex Ligands Based on Carbohydrate Naphthalene Diimide Conjugates
Autor: Mauro Freccero, Filippo Doria, Jean-Louis Mergny, Ricardo Lucas, Efres Belmonte-Reche, Matilde Arévalo-Ruiz, Eva Falomir, Juan Carlos Morales, José M. Pérez-Victoria, Jenny Campos-Salinas, Miguel Carda, Aurore De Rache
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
The G-quadruplexes (G4s) are currently being explored as therapeutic targets in cancer and other pathologies. Six carbohydrate naphthalene diimide conjugates (carb-NDIs) have been synthesized as G4 ligands to investigate their potential selectivity i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e5fef74b33bfeaeae7b1cf25a1a653f
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Synthesis, RNAi activity and nuclease-resistant properties of apolar carbohydrates siRNA conjugates
Autor: Empar Vengut-Climent, Ramon Eritja, Ricardo Lucas, Matilde Arévalo-Ruiz, Juan C. Morales, Montserrat Terrazas
Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
instname
Oligoribonucleotide conjugates carrying apolar carbohydrates at the 5′-end and the corresponding siRNA duplexes have been prepared using phosphoramidite chemistry. All the carbohydrate-siRNA derivatives were compatible with RNA interference machine
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64fc5f69c1240f7e4f2704fc39ff02aa
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