Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Matilda Katan"'
Autor:
Lorenza Magno, Christian B. Lessard, Marta Martins, Verena Lang, Pedro Cruz, Yasmine Asi, Matilda Katan, Jamie Bilsland, Tammaryn Lashley, Paramita Chakrabarty, Todd E. Golde, Paul J. Whiting
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-11 (2019)
Abstract Background Recent Genome Wide Association Studies (GWAS) have identified novel rare coding variants in immune genes associated with late onset Alzheimer’s disease (LOAD). Amongst these, a polymorphism in phospholipase C-gamma 2 (PLCG2) P52
Externí odkaz:
https://doaj.org/article/fec71a324e774372957bdf37f9b9949b
Autor:
Yang Liu, Tom D. Bunney, Sakshi Khosa, Kévin Macé, Katharina Beckenbauer, Trevor Askwith, Sarah Maslen, Christopher Stubbs, Taiana M. de Oliveira, Kasim Sader, Mark Skehel, Anne-Claude Gavin, Christopher Phillips, Matilda Katan
Publikováno v:
EBioMedicine, Vol 51, Iss , Pp - (2020)
Background: PLCγ enzymes are key nodes in cellular signal transduction and their mutated and rare variants have been recently implicated in development of a range of diseases with unmet need including cancer, complex immune disorders, inflammation a
Externí odkaz:
https://doaj.org/article/fae72e0deddd4347abbae01996f625e8
Autor:
João Farela Neves, Rainer Doffinger, Gabriela Barcena-Morales, Catarina Martins, Olivier Papapietro, Vincent Plagnol, James Curtis, Marta Martins, Dinakantha Kumararatne, Ana Isabel Cordeiro, Conceição Neves, Luis Miguel Borrego, Matilda Katan, Sergey Nejentsev
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Background: The auto-inflammation and phospholipase Cγ2 (PLCγ2)-associated antibody deficiency and immune dysregulation (APLAID) syndrome is a rare primary immunodeficiency caused by a gain-of-function mutation S707Y in the PLCG2 gene previously de
Externí odkaz:
https://doaj.org/article/b006da5dea034c7dba115a83f6011023
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 9, p 3214 (2020)
Selective FGFR inhibitors such as infigratinib (BGJ398) and erdafitinib (JNJ-42756493) have been evaluated in clinical trials for cancers with FGFR3 molecular alterations, particularly in urothelial carcinoma patients. However, a substantial proporti
Externí odkaz:
https://doaj.org/article/348e2e7415aa42b9be2a74261d57526b
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 7, Pp 14695-14716 (2015)
Multiplexed imaging of Förster Resonance Energy Transfer (FRET)-based biosensors potentially presents a powerful approach to monitoring the spatio-temporal correlation of signalling pathways within a single live cell. Here, we discuss the potential
Externí odkaz:
https://doaj.org/article/b9373e8b0b1b48aabe611b31f8c57a6f
Publikováno v:
EuPA Open Proteomics, Vol 6, Iss C, Pp 10-15 (2015)
Defining alterations in signalling pathways in normal and malignant cells is becoming a major field in proteomics. A number of different approaches have been established to isolate, identify and quantify phosphorylated proteins and peptides. In the c
Externí odkaz:
https://doaj.org/article/00c9ed7abbd9411fbddc3991720342ce
Autor:
Tom D. Bunney, Shunzhou Wan, Nethaji Thiyagarajan, Ludovico Sutto, Sarah V. Williams, Paul Ashford, Hans Koss, Margaret A. Knowles, Francesco L. Gervasio, Peter V. Coveney, Matilda Katan
Publikováno v:
EBioMedicine, Vol 2, Iss 3, Pp 194-204 (2015)
Fibroblast growth factor receptors (FGFRs) are recognized therapeutic targets in cancer. We here describe insights underpinning the impact of mutations on FGFR1 and FGFR3 kinase activity and drug efficacy, using a combination of computational calcula
Externí odkaz:
https://doaj.org/article/e7769dd69808422f83cb4585092a329f
Autor:
Teresa Correia, Nicola Lockwood, Sunil Kumar, Jun Yin, Marie-Christine Ramel, Natalie Andrews, Matilda Katan, Laurence Bugeon, Margaret J Dallman, James McGinty, Paul Frankel, Paul M W French, Simon Arridge
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136213 (2015)
Optical projection tomography (OPT) provides a non-invasive 3-D imaging modality that can be applied to longitudinal studies of live disease models, including in zebrafish. Current limitations include the requirement of a minimum number of angular pr
Externí odkaz:
https://doaj.org/article/eae988d6cb564d16940f27eadabb8af0
Autor:
Sean C Warren, Anca Margineanu, Dominic Alibhai, Douglas J Kelly, Clifford Talbot, Yuriy Alexandrov, Ian Munro, Matilda Katan, Chris Dunsby, Paul M W French
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70687 (2013)
Fluorescence lifetime imaging (FLIM) is widely applied to obtain quantitative information from fluorescence signals, particularly using Förster Resonant Energy Transfer (FRET) measurements to map, for example, protein-protein interactions. Extractin
Externí odkaz:
https://doaj.org/article/3c32e3b4a7934189900676da53ff1637
Autor:
Grace Q. Gong, Benoit Bilanges, Ben Allsop, Glenn R. Masson, Victoria Roberton, Trevor Askwith, Sally Oxenford, Ralitsa R. Madsen, Sarah E. Conduit, Dom Bellini, Martina Fitzek, Matt Collier, Osman Najam, Zhenhe He, Ben Wahab, Stephen H. McLaughlin, A. W. Edith Chan, Isabella Feierberg, Andrew Madin, Daniele Morelli, Amandeep Bhamra, Vanesa Vinciauskaite, Karen E. Anderson, Silvia Surinova, Nikos Pinotsis, Elena Lopez-Guadamillas, Matthew Wilcox, Alice Hooper, Chandni Patel, Maria A. Whitehead, Tom D. Bunney, Len R. Stephens, Phillip T. Hawkins, Matilda Katan, Derek M. Yellon, Sean M. Davidson, David M. Smith, James B. Phillips, Richard Angell, Roger L. Williams, Bart Vanhaesebroeck
Publikováno v:
Nature. 618:159-168