Rebalancing of mitochondrial homeostasis through an NAD+-SIRT1 pathway preserves intestinal barrier function in severe malnutritionResearch in context

Autor: Catriona Ling, Christian J. Versloot, Matilda E. Arvidsson Kvissberg, Guanlan Hu, Nathan Swain, José M. Horcas-Nieto, Emily Miraglia, Mehakpreet K. Thind, Amber Farooqui, Albert Gerding, Karen van Eunen, Mirjam H. Koster, Niels J. Kloosterhuis, Lijun Chi, YueYing ChenMi, Miriam Langelaar-Makkinje, Celine Bourdon, Jonathan Swann, Marieke Smit, Alain de Bruin, Sameh A. Youssef, Marjon Feenstra, Theo H. van Dijk, Kathrin Thedieck, Johan W. Jonker, Peter K. Kim, Barbara M. Bakker, Robert H.J. Bandsma

Publikováno v: EBioMedicine, Vol 96, Iss , Pp 104809- (2023)

Summary: Background: The intestine of children with severe malnutrition (SM) shows structural and functional changes that are linked to increased infection and mortality. SM dysregulates the tryptophan-kynurenine pathway, which may impact processes s

Externí odkaz: https://doaj.org/article/030dcd61c99342418554af2a1f59e28d

Urinary Organic Acids Increase After Clinical Stabilization of Hospitalized Children With Severe Acute Malnutrition

Autor: Celine Bourdon, Allison I Daniel, Robert H. J. Bandsma, David S. Wishart, Wieger Voskuijl, Philliness Prisca Harawa, Edward Senga, Rupasri Mandal, Matilda E. Arvidsson Kvissberg, Christian J. Versloot

Publikováno v: Food and nutrition bulletin, 40(4), 532-543. SAGE Publications Inc.
Food and Nutrition Bulletin, 40(4), 532-543. SAGE Publications Inc.

Background:Despite a reduction of child mortality in low-income countries, acutely ill undernourished children still have an elevated risk of death. Those at highest risk are children with severe acute malnutrition (SAM) who often show metabolic dysr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::382d928c536380f2351f7ed919926473
https://research.rug.nl/en/publications/c2d9cf2d-a98a-421e-9771-98315ac551aa

Urinary Organic Acids Increase After Clinical Stabilization of Hospitalized Children With Severe Acute Malnutrition.

Autor: Daniel AI; Hospital for Sick Children, Toronto, Canada.; Faculty of Medicine, University of Toronto, Toronto, Canada.; Allison I. Daniel and Matilda E. Arvidsson Kvissberg are co-first authors., Kvissberg MEA; Hospital for Sick Children, Toronto, Canada.; University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Allison I. Daniel and Matilda E. Arvidsson Kvissberg are co-first authors., Senga E; College of Medicine, University of Malawi, Blantyre, Malawi., Versloot CJ; University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Harawa PP; College of Medicine, University of Malawi, Blantyre, Malawi., Voskuijl W; College of Medicine, University of Malawi, Blantyre, Malawi.; The Childhood Acute Illness and Nutrition Network, Narobi, Kenya.; Academic Medical Centre, University of Amsterdam, The Netherlands., Wishart D; University of Alberta, Edmonton, Canada., Mandal R; University of Alberta, Edmonton, Canada., Bandsma R; Hospital for Sick Children, Toronto, Canada.; Faculty of Medicine, University of Toronto, Toronto, Canada.; University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; College of Medicine, University of Malawi, Blantyre, Malawi.; The Childhood Acute Illness and Nutrition Network, Narobi, Kenya., Bourdon C; Hospital for Sick Children, Toronto, Canada.; The Childhood Acute Illness and Nutrition Network, Narobi, Kenya.

Publikováno v: Food and nutrition bulletin [Food Nutr Bull] 2019 Dec; Vol. 40 (4), pp. 532-543. Date of Electronic Publication: 2019 Jul 14.