Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Matilda Ayidah"'
Autor:
Aldo Spanjaard, Maria Stratigopoulou, Daniël de Groot, Muhammad Aslam, Paul C. M. van den Berk, Chantal Stappenbelt, Matilda Ayidah, Joyce J. I. Catsman, Iris N. Pardieck, Maaike Kreft, Ramon Arens, Jeroen E. J. Guikema, Heinz Jacobs
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
The development and differentiation of B cells is intimately linked to cell proliferation and the generation of diverse immunoglobulin gene (Ig) repertoires. The ubiquitin E3 ligase HUWE1 controls proliferation, DNA damage responses, and DNA repair,
Externí odkaz:
https://doaj.org/article/1d18cf86772b41ecb3b2e4147ddbb1f9
Autor:
Olimpia Alessandra Buoninfante, Bas Pilzecker, Aldo Spanjaard, Daniël de Groot, Stefan Prekovic, Ji-Ying Song, Cor Lieftink, Matilda Ayidah, Colin E. J. Pritchard, Judith Vivié, Kathleen E. Mcgrath, Ivo J. Huijbers, Sjaak Philipsen, Marieke von Lindern, Wilbert Zwart, Roderick L. Beijersbergen, James Palis, Paul C. M. van den Berk, Heinz Jacobs
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 120(4):e2216055120. National Academy of Sciences
DNA damage threatens genomic integrity and instigates stem cell failure. To bypass genotoxic lesions during replication, cells employ DNA damage tolerance (DDT), which is regulated via PCNA ubiquitination and REV1. DDT is conserved in all domains of