Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Matija Hedl"'
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 249-272 (2021)
Background & Aims: TNFSF15 genetic variants leading to increased TNF superfamily member 15 (TNFSF15) expression confer risk for inflammatory bowel disease (IBD), and TNFSF15 is being explored as a therapeutic target in IBD patients. Although the focu
Externí odkaz:
https://doaj.org/article/8091787e7f4c4295b14400ea41ae3ae8
Publikováno v:
Cell Reports, Vol 29, Iss 13, Pp 4525-4539.e4 (2019)
Summary: LACC1 genetic variants are associated with multiple immune-mediated diseases. However, laccase domain containing-1 (LACC1) functions are incompletely defined. We find that upon stimulation of the pattern-recognition receptor (PRR) NOD2, LACC
Externí odkaz:
https://doaj.org/article/5a6e5438ed2549e8a1c775263ccfd562
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
LACC1 genetic variants are associated with Crohn's disease, leprosy and arthritis. Here the authors show that LACC1 is needed for optimal innate receptor-induced signalling, mitochondrial ROS production and microbial clearance, effects that are reduc
Externí odkaz:
https://doaj.org/article/b3899d585b3a48d7aef42d5a79383ca3
Autor:
Pradeep Bist, Wan Shoo Cheong, Aylwin Ng, Neha Dikshit, Bae-Hoon Kim, Niyas Kudukkil Pulloor, Hanif Javanmard Khameneh, Matija Hedl, Avinash R. Shenoy, Vanniarajan Balamuralidhar, Najib Bin Abdul Malik, Michelle Hong, Albert Neutzner, Keh-Chuang Chin, Koichi S. Kobayashi, Antonio Bertoletti, Alessandra Mortellaro, Clara Abraham, John D. MacMicking, Ramnik J. Xavier, Bindu Sukumaran
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Prolonged NOD2 ligand engagement induces tolerance and attenuated NOD2 signalling, but the molecular mechanisms leading to this tolerance induction are unclear. Here the authors show that the degradation of a NOD2 adaptor, RIP2, by the E3 ligase ZNRF
Externí odkaz:
https://doaj.org/article/fcfe5f0cdf014198b141e4fc270fc775
Autor:
Phi Luong, Matija Hedl, Jie Yan, Tao Zuo, Tian-Min Fu, Xiaomo Jiang, Jay R Thiagarajah, Steen H Hansen, Cammie F Lesser, Hao Wu, Clara Abraham, Wayne I Lencer
Publikováno v:
eLife, Vol 7 (2018)
Homeostasis at mucosal surfaces requires cross-talk between the environment and barrier epithelial cells. Disruption of barrier function typifies mucosal disease. Here we elucidate a bifunctional role in coordinating this cross-talk for the inflammat
Externí odkaz:
https://doaj.org/article/88d7b7c576ce48a69294af2d0e3bf0e0
Publikováno v:
Cell Reports, Vol 16, Iss 9, Pp 2442-2455 (2016)
Interferon regulatory factor 5 (IRF5) regulates inflammatory M1 macrophage polarization, and disease-associated IRF5 genetic variants regulate pattern-recognition-receptor (PRR)-induced cytokines. PRR-stimulated macrophages and M1 macrophages exhibit
Externí odkaz:
https://doaj.org/article/1857f699eade4cb2af4d2d56d1fb6170
Erratum: E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP
Autor:
Pradeep Bist, Wan Shoo Cheong, Aylwin Ng, Neha Dikshit, Bae Hoon Kim, Niyas Kudukkil Pulloor, Hanif Javanmard Khameneh, Matija Hedl, Avinash R. Shenoy, Vanniarajan Balamuralidhar, Najib Bin Abdul Malik, Michelle Hong, Albert Neutzner, Keh-Chuang Chin, Koichi S. Kobayashi, Antonio Bertoletti, Alessandra Mortellaro, Clara Abraham, John D. MacMicking, Ramnik J. Xavier, Bindu Sukumaran
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 8 Article number: 15865 (2017); Published: 28 June 2017; Updated: 18 August 2017 The previously published version of this Article contained a line number in the Abstract within the sentence ‘A fraction of RIP2 localizes to the
Externí odkaz:
https://doaj.org/article/ddffffb5080b4efba26d0571887e537d
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 249-272 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 249-272 (2021)
Background & Aims TNFSF15 genetic variants leading to increased TNF superfamily member 15 (TNFSF15) expression confer risk for inflammatory bowel disease (IBD), and TNFSF15 is being explored as a therapeutic target in IBD patients. Although the focus
Publikováno v:
J Immunol
STAT proteins can regulate both pro- and anti-inflammatory cytokine signaling. Therefore, identifying consequences of modulating expression of a given STAT is ultimately critical for determining its potential as a therapeutic target and for defining
Publikováno v:
The Journal of Immunology. 205:1024-1038
Common IRF5 genetic risk variants associated with multiple immune-mediated diseases are a major determinant of interindividual variability in pattern-recognition receptor (PRR)–induced cytokines in myeloid cells. However, how myeloid cell–intrins