Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Matic Pavlin"'
1
Akademický článek
Unveiling the interdomain dynamics of type II DNA topoisomerase through all-atom simulations: Implications for understanding its catalytic cycle
Autor: Matic Pavlin, Barbara Herlah, Katja Valjavec, Andrej Perdih
Publikováno v: Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 3746-3759 (2023)
Type IIA DNA topoisomerases are complex molecular nanomachines that manage topological states of the DNA molecule in the cell and play a crucial role in cellular processes such as cell division and transcription. They are also established targets of
Externí odkaz: https://doaj.org/article/af5922e15c6647aaaaf88d94212b6d0a
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2
Akademický článek
Disrupting Cu trafficking as a potential therapy for cancer
Autor: Zena Qasem, Matic Pavlin, Ida Ritacco, Matan Y. Avivi, Shelly Meron, Melanie Hirsch, Yulia Shenberger, Lada Gevorkyan-Airapetov, Alessandra Magistrato, Sharon Ruthstein
Publikováno v: Frontiers in Molecular Biosciences, Vol 9 (2022)
Copper ions play a crucial role in various cellular biological processes. However, these copper ions can also lead to toxicity when their concentration is not controlled by a sophisticated copper-trafficking system. Copper dys-homeostasis has been li
Externí odkaz: https://doaj.org/article/6533b83f68644535a673de81dcc7294c
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3
Akademický článek
A Rapid Prototyped Thermal Mass Flowmeter
Autor: Borut Pečar, Danilo Vrtačnik, Matic Pavlin, Matej Možek
Publikováno v: Sensors, Vol 21, Iss 16, p 5373 (2021)
An innovative rapid prototyping technique for embedding microcomponents in PDMS replicas was developed and applied on a thermal mass flowmeter for closed loop micropump flowrate control. Crucial flowmeter design and thermal parameters were investigat
Externí odkaz: https://doaj.org/article/b49479dc313d4ed6b97e1c52c8ddb69d
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4
Akademický článek
Structural, Thermodynamic, and Kinetic Traits of Antiestrogen-Compounds Selectively Targeting the Y537S Mutant Estrogen Receptor α Transcriptional Activity in Breast Cancer Cell Lines
Autor: Matic Pavlin, Luca Gelsomino, Ines Barone, Angelo Spinello, Stefania Catalano, Sebastiano Andò, Alessandra Magistrato
Publikováno v: Frontiers in Chemistry, Vol 7 (2019)
The most frequently diagnosed cancers in women are the estrogen receptor (ER)-positive breast cancer subtypes, which are characterized by estrogen dependency for their growth. The mainstay of clinical treatment for this tumor relies on the modulation
Externí odkaz: https://doaj.org/article/f8392ec5b07546f1a73cfafd4b6f19ad
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5
Akademický článek
Unraveling the Impact of Cysteine-to-Serine Mutations on the Structural and Functional Properties of Cu(I)-Binding Proteins
Autor: Matic Pavlin, Zena Qasem, Hila Sameach, Lada Gevorkyan-Airapetov, Ida Ritacco, Sharon Ruthstein, Alessandra Magistrato
Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 14, p 3462 (2019)
Appropriate maintenance of Cu(I) homeostasis is an essential requirement for proper cell function because its misregulation induces the onset of major human diseases and mortality. For this reason, several research efforts have been devoted to dissec
Externí odkaz: https://doaj.org/article/091d278831804f88b734b873c8c4fd15
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6
A rapid prototyped thermal mass flowmeter
Autor: Danilo Vrtačnik, Matic Pavlin, Matej Možek, Borut Pečar
Publikováno v: Sensors, vol. 21, no. 16, 5373, 2021.
Sensors, Vol 21, Iss 5373, p 5373 (2021)
Sensors (Basel, Switzerland)
Sensors
Volume 21
Issue 16
An innovative rapid prototyping technique for embedding microcomponents in PDMS replicas was developed and applied on a thermal mass flowmeter for closed loop micropump flowrate control. Crucial flowmeter design and thermal parameters were investigat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9fd35bc233c0f8233d9c3756c404c76
https://hdl.handle.net/20.500.12556/RUL-135980
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8
Computing Metal-Binding Proteins for Therapeutic Benefit
Autor: Angelo Spinello, Matic Pavlin, Pavel Janoš, Jure Borišek, Alessandra Magistrato
Over one third of biomolecules rely on metal ions to exert their cellular functions. Metal ions can play a structural role by stabilizing the structure of biomolecules, a functional role by promoting a wide variety of biochemical reactions, and a reg
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31ece7ab7df6a8374c18cfc60a22f18
http://hdl.handle.net/10447/535283
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9
The pivotal role of MBD4–ATP7B in the human Cu(i) excretion path as revealed by EPR experiments and all-atom simulations
Autor: Ida Ritacco, Lada Gevorkyan-Airapetov, Sharon Ruthstein, Matic Pavlin, Zena Qasem, Alessandra Magistrato
Publikováno v: Metallomics
11 (2019): 1288–1297. doi:10.1039/c9mt00067d
info:cnr-pdr/source/autori:Qasem Z.; Pavlin M.; Ritacco I.; Gevorkyan-Airapetov L.; Magistrato A.; Ruthstein S./titolo:The pivotal role of MBD4-ATP7B in the human Cu(i) excretion path as revealed by EPR experiments and all-atom simulations/doi:10.1039%2Fc9mt00067d/rivista:Metallomics (Print)/anno:2019/pagina_da:1288/pagina_a:1297/intervallo_pagine:1288–1297/volume:11
Copper's essentiality and toxicity require a meticulous mechanism for its acquisition, cellular distribution and excretion, which remains hitherto elusive. Herein, we jointly employed electron paramagnetic resonance spectroscopy and all-atom simulati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8adb44f00e85bb7d980f74c20475a72d
https://doi.org/10.1039/c9mt00067d
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10
Structural, Thermodynamic, and Kinetic Traits of Antiestrogen-Compounds Selectively Targeting the Y537S Mutant Estrogen Receptor α Transcriptional Activity in Breast Cancer Cell Lines
Autor: Alessandra Magistrato, Stefania Catalano, Angelo Spinello, Luca Gelsomino, Ines Barone, Sebastiano Andò, Matic Pavlin
Publikováno v: Frontiers in Chemistry
Frontiers in Chemistry, Vol 7 (2019)
Frontiers in Chemistry 7 (2019). doi:10.3389/fchem.2019.00602
info:cnr-pdr/source/autori:Pavlin M.; Gelsomino L.; Barone I.; Spinello A.; Catalano S.; Ando S.; Magistrato A./titolo:Structural, Thermodynamic, and Kinetic Traits of Antiestrogen-Compounds Selectively Targeting the Y537S Mutant Estrogen Receptor ? Transcriptional Activity in Breast Cancer Cell Lines/doi:10.3389%2Ffchem.2019.00602/rivista:Frontiers in Chemistry/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:7
The most frequently diagnosed cancers in women are the estrogen receptor (ER)-positive breast cancer subtypes, which are characterized by estrogen dependency for their growth. The mainstay of clinical treatment for this tumor relies on the modulation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4dab8912f6fedee2c2d686c56e1cfa8
https://pubmed.ncbi.nlm.nih.gov/31552220
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