Ustekinumab Dosing Individualization in Crohn’s Disease Guided by a Population Pharmacokinetic–Pharmacodynamic Model

Autor: Jurij Aguiar Zdovc, Jurij Hanžel, Tina Kurent, Nejc Sever, Matic Koželj, Nataša Smrekar, Gregor Novak, Borut Štabuc, Erwin Dreesen, Debby Thomas, Tomaž Vovk, Barbara Ostanek, David Drobne, Iztok Grabnar

Publikováno v: Pharmaceutics, Vol 13, Iss 10, p 1587 (2021)

Ustekinumab is a monoclonal antibody used in Crohn’s disease (CD). Dose optimization in case of non-response and the role of pharmacokinetic–pharmacodynamic (PK-PD) monitoring remain unresolved dilemmas in clinical practice. We aimed to develop a

Externí odkaz: https://doaj.org/article/da2b1fcaede847e99d10755cafa7954d

Natural History and Risk Stratification of Recurrent Crohn's Disease After Ileocolonic Resection: A Multicenter Retrospective Cohort Study

Autor: Pieter Hindryckx, Vincent W. Joustra, Nahid Mostafavi, Christianne J. Buskens, Willem A. Bemelman, Gregor Novak, Aart Mookhoek, Marjolijn Duijvestein, Geert R. D'Haens, Matic Koželj

Publikováno v: Inflammatory Bowel Diseases, 28, 1-8
Inflammatory bowel diseases, 28(1), 1-8. John Wiley and Sons Inc.
Inflammatory Bowel Diseases, 28, 1, pp. 1-8
Joustra, V, Duijvestein, M, Mookhoek, A, Bemelman, W, Buskens, C, Koželj, M, Novak, G, Hindryckx, P, Mostafavi, N & D'Haens, G 2022, ' Natural History and Risk Stratification of Recurrent Crohn's Disease after Ileocolonic Resection : A Multicenter Retrospective Cohort Study ', Inflammatory Bowel Diseases, vol. 28, no. 1, pp. 1-8 . https://doi.org/10.1093/ibd/izab044
Inflammatory Bowel Diseases
Inflammatory Bowel Diseases, 28(1), 1-8. John Wiley and Sons Inc.

Background Prediction of endoscopic postoperative recurrence (POR) and prophylactic treatment based on clinical risk profile have thus far been inconclusive. This study aimed to examine the association between clinical risk profile and the developmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf1c9b65ee7cbdeb42c30c77ed085e8
https://doi.org/10.1093/ibd/izab044

Early vedolizumab trough levels predict combined endoscopic and clinical remission in inflammatory bowel disease

Autor: Sophie Tops, Matic Koželj, Jurij Hanžel, Gregor Novak, Ann Gils, Borut Štabuc, Ivan Ferkolj, Griet Compernolle, Nejc Sever, David Drobne, Nataša Smrekar, Tina Kurent

Publikováno v: United European Gastroenterology Journal. 7:741-749

BACKGROUND: The relationship between vedolizumab trough levels and combined endoscopic and clinical remission is unknown. OBJECTIVE: To compare vedolizumab trough levels in patients with and without combined remission within the first year of treatme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c503a83684a732d7b58b473f5580c5
https://doi.org/10.1177/2050640619840211

Anorectal Dysfunction in Presymptomatic Mutation Carriers and Patients with Huntington’s Disease

Autor: Simon Podnar, Kolenc Matej, Matic Koželj, Jan Kobal

Publikováno v: Journal of Huntington's Disease. 7:259-267

BACKGROUND Huntington's disease (HD) patients often report anorectal dysfunction; however, in HD research no detailed analysis of these complaints has been published. OBJECTIVE To report anorectal dysfunction in a systematically studied cohort of HD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e90fc48a92968bec4fc2e61ab8f1d604
https://doi.org/10.3233/jhd-170280

Optimised infliximab monotherapy is as effective as optimised combination therapy, but is associated with higher drug consumption in inflammatory bowel disease

Autor: Jurij Hanžel, Polona Rajar, Gregor Novak, Matic Koželj, Sasa Golob, Ivan Ferkolj, Polona Svegl, Borut Štabuc, David Drobne, Nataša Smrekar, Tina Kurent

Publikováno v: Alimentary pharmacologytherapeutics. 49(7)

Background Combination treatment with azathioprine for 6-12 months is the preferred strategy for starting infliximab due to improved pharmacokinetics. However, optimised infliximab monotherapy with proactive dose escalations in case of low trough lev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4d11853c55c50bf737aa46740b4b17
https://pubmed.ncbi.nlm.nih.gov/30784100