Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Matias S. Attene-Ramos"'
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 84:710-728
In vivo animal bioassays are increasingly being supplemented with in vitro assays to serve as the new standard for chemical toxicity tests. Despite this shift, investigators face challenges related...
Publikováno v:
Methods in Molecular Biology ISBN: 9781071622124
Methods Mol Biol
Methods Mol Biol
Mitochondrial function, a key indicator of cell health, can be assessed through monitoring changes in mitochondrial membrane potential (MMP). Cationic fluorescent dyes are commonly used tools to assess MMP. We used a water-soluble mitochondrial membr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99383b96ef809be8e9e870d44af5095d
https://doi.org/10.1007/978-1-0716-2213-1_2
https://doi.org/10.1007/978-1-0716-2213-1_2
Publikováno v:
Journal of toxicology and environmental health. Part A. 84(17)
Publikováno v:
Science of The Total Environment. 800:149556
Rare earth element (REE) coagulants are prime contenders in wastewater treatment plants to remove phosphorus; unlike typical coagulants, they are not affected by pH. However, the use of REEs in wastewater treatment could mean increased human exposure
Publikováno v:
Journal of Environmental Sciences. 58:224-230
Haloacetamides (HAMs) are cytotoxic, genotoxic, and mutagenic byproducts of drinking water disinfection. They are soft electrophilic compounds that form covalent bonds with the free thiol/thiolate in cysteine residues through an SN2 reaction mechanis
Autor:
Menghang Xia, Ruili Huang, Anton Simeonov, Srilatha Sakamuru, Jinghua Zhao, Sampada A. Shahane, Tongan Zhao, Matias S. Attene-Ramos, Christopher P. Austin
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications
Nature Communications
Target-specific, mechanism-oriented in vitro assays post a promising alternative to traditional animal toxicology studies. Here we report the first comprehensive analysis of the Tox21 effort, a large-scale in vitro toxicity screening of chemicals. We
Autor:
Raymond R. Tice, Anton Simeonov, Matias S. Attene-Ramos, Ann M. Richard, Menghang Xia, Ruili Huang, Sam Michael, Christopher P. Austin, Kristine L. Witt
Publikováno v:
Environmental Health Perspectives
Background: Mitochondrial dysfunction has been implicated in the pathogenesis of a variety of disorders including cancer, diabetes, and neurodegenerative and cardiovascular diseases. Understanding whether different environmental chemicals and druglik
Autor:
Rick G. Schnellmann, Ruili Huang, Matias S. Attene-Ramos, Louie Shou, Gyda C. Beeson, Christopher P. Austin, Raymond R. Tice, Craig Beeson, Kristine L. Witt, Srilatha Sakamuru, Menghang Xia
Publikováno v:
Chemical Research in Toxicology. 26:1323-1332
A goal of the Tox21 program is to transit toxicity testing from traditional in vivo models to in vitro assays that assess how chemicals affect cellular responses and toxicity pathways. A critical contribution of the NIH Chemical Genomics center (NCGC
Publikováno v:
Methods in Molecular Biology ISBN: 9781493963447
Mitochondrial function, a key indicator of cell health, can be assessed by monitoring changes in mitochondrial membrane potential (MMP). Cationic fluorescent dyes are commonly used tools to assess MMP. We used a water-soluble mitochondrial membrane p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea99ea4f9552aa483dff2edb0c139c0d
https://europepmc.org/articles/PMC5375165/
https://europepmc.org/articles/PMC5375165/
Autor:
James Inglese, Srilatha Sakamuru, Wenwei Huang, Erika Englund, Matias S. Attene-Ramos, Menghang Xia, Christopher P. Austin, Ruili Huang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5239-5243
Quinazolin-4-one 1 was identified as an inhibitor of the HIF-1α transcriptional factor from a high-throughput screen. HIF-1α up-regulation is common in many cancer cells. In this Letter, we describe an efficient one-pot sequential reaction for the