Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Matias S. Attene-Ramos"'
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 84:710-728
In vivo animal bioassays are increasingly being supplemented with in vitro assays to serve as the new standard for chemical toxicity tests. Despite this shift, investigators face challenges related...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90dbb4d52a8ded85829eb466a0134892
https://doi.org/10.1080/15287394.2021.1937418
https://doi.org/10.1080/15287394.2021.1937418
Publikováno v:
Methods in Molecular Biology ISBN: 9781071622124
Methods Mol Biol
Methods Mol Biol
Mitochondrial function, a key indicator of cell health, can be assessed through monitoring changes in mitochondrial membrane potential (MMP). Cationic fluorescent dyes are commonly used tools to assess MMP. We used a water-soluble mitochondrial membr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99383b96ef809be8e9e870d44af5095d
https://doi.org/10.1007/978-1-0716-2213-1_2
https://doi.org/10.1007/978-1-0716-2213-1_2
Publikováno v:
Journal of toxicology and environmental health. Part A. 84(17)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1e01a765de027bcea0764bd268dc478e
https://pubmed.ncbi.nlm.nih.gov/34102960
https://pubmed.ncbi.nlm.nih.gov/34102960
Publikováno v:
Science of The Total Environment. 800:149556
Rare earth element (REE) coagulants are prime contenders in wastewater treatment plants to remove phosphorus; unlike typical coagulants, they are not affected by pH. However, the use of REEs in wastewater treatment could mean increased human exposure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616890d33d61a52b76083d550e9c4ebd
https://doi.org/10.1016/j.scitotenv.2021.149556
https://doi.org/10.1016/j.scitotenv.2021.149556
Publikováno v:
Journal of Environmental Sciences. 58:224-230
Haloacetamides (HAMs) are cytotoxic, genotoxic, and mutagenic byproducts of drinking water disinfection. They are soft electrophilic compounds that form covalent bonds with the free thiol/thiolate in cysteine residues through an SN2 reaction mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8fd3a399360e21a2a90221b00bb920a
https://doi.org/10.1016/j.jes.2017.04.027
https://doi.org/10.1016/j.jes.2017.04.027
Autor:
Menghang Xia, Ruili Huang, Anton Simeonov, Srilatha Sakamuru, Jinghua Zhao, Sampada A. Shahane, Tongan Zhao, Matias S. Attene-Ramos, Christopher P. Austin
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications
Nature Communications
Target-specific, mechanism-oriented in vitro assays post a promising alternative to traditional animal toxicology studies. Here we report the first comprehensive analysis of the Tox21 effort, a large-scale in vitro toxicity screening of chemicals. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2899e9e247331f3b58825a7dc2c5d40
https://doaj.org/article/6aedca7233ad4d39b830fe9c531524db
https://doaj.org/article/6aedca7233ad4d39b830fe9c531524db
Autor:
Raymond R. Tice, Anton Simeonov, Matias S. Attene-Ramos, Ann M. Richard, Menghang Xia, Ruili Huang, Sam Michael, Christopher P. Austin, Kristine L. Witt
Publikováno v:
Environmental Health Perspectives
Background: Mitochondrial dysfunction has been implicated in the pathogenesis of a variety of disorders including cancer, diabetes, and neurodegenerative and cardiovascular diseases. Understanding whether different environmental chemicals and druglik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d5580e85582f0cc5483f7e9606f284
http://europepmc.org/articles/PMC4286281
http://europepmc.org/articles/PMC4286281
Autor:
Rick G. Schnellmann, Ruili Huang, Matias S. Attene-Ramos, Louie Shou, Gyda C. Beeson, Christopher P. Austin, Raymond R. Tice, Craig Beeson, Kristine L. Witt, Srilatha Sakamuru, Menghang Xia
Publikováno v:
Chemical Research in Toxicology. 26:1323-1332
A goal of the Tox21 program is to transit toxicity testing from traditional in vivo models to in vitro assays that assess how chemicals affect cellular responses and toxicity pathways. A critical contribution of the NIH Chemical Genomics center (NCGC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5fc534d413506eedb2fca52a6ac23c5
https://doi.org/10.1021/tx4001754
https://doi.org/10.1021/tx4001754
Autor:
James Inglese, Srilatha Sakamuru, Wenwei Huang, Erika Englund, Matias S. Attene-Ramos, Menghang Xia, Christopher P. Austin, Ruili Huang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5239-5243
Quinazolin-4-one 1 was identified as an inhibitor of the HIF-1α transcriptional factor from a high-throughput screen. HIF-1α up-regulation is common in many cancer cells. In this Letter, we describe an efficient one-pot sequential reaction for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786af77f1c5417ac4f9ee5a8a3b23866
https://doi.org/10.1016/j.bmcl.2011.07.043
https://doi.org/10.1016/j.bmcl.2011.07.043
Autor:
Susan D. Richardson, Michael J. Plewa, Elizabeth D. Wagner, Christopher T. Cornelison, Stephen E. Duirk, Jennifer Lynne Kormos, Jennifer Osiol, Thomas A. Ternes, Matias S. Attene-Ramos, Cristal Lindell
Publikováno v:
Environmental Science & Technology. 45:6845-6854
Iodinated X-ray contrast media (ICM) were investigated as a source of iodine in the formation of iodo-trihalomethane (iodo-THM) and iodo-acid disinfection byproducts (DBPs), both of which are highly genotoxic and/or cytotoxic in mammalian cells. ICM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7fa455371c5f362b0b9e9a15b0bbcb9
https://doi.org/10.1021/es200983f
https://doi.org/10.1021/es200983f