Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Matias Morin"'
Autor:
Morag A. Lewis, Maria Lachgar-Ruiz, Francesca Di Domenico, Graham Duddy, Jing Chen, Sergio Fernandez, Matias Morin, Gareth Williams, Miguel Angel Moreno Pelayo, Karen P. Steel
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract Background Progressive hearing loss is a common problem in the human population with no effective therapeutics currently available. However, it has a strong genetic contribution, and investigating the genes and regulatory interactions underl
Externí odkaz:
https://doaj.org/article/18ebda7be878464080ab6f75b1462e0e
Autor:
Borja Alonso-Lerma, Ylenia Jabalera, Sara Samperio, Matias Morin, Almudena Fernandez, Logan T. Hille, Rachel A. Silverstein, Ane Quesada-Ganuza, Antonio Reifs, Sergio Fernández-Peñalver, Yolanda Benitez, Lucia Soletto, Jose A. Gavira, Adrian Diaz, Wim Vranken, Avencia Sanchez-Mejias, Marc Güell, Francisco J. M. Mojica, Benjamin P. Kleinstiver, Miguel A. Moreno-Pelayo, Lluis Montoliu, Raul Perez-Jimenez
Publikováno v:
Nat Microbiol
Clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas9 is an effector protein that targets invading DNA and plays a major role in the prokaryotic adaptive immune system. Although Streptococcus pyogenes CRISPR–Cas9 has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53d8df2c46392fb5741544f0f76fd3d
https://doi.org/10.1038/s41564-022-01265-y
https://doi.org/10.1038/s41564-022-01265-y
Autor:
Saint T. Cervera, Sergio Fernández-Peñalver, Jorge Amhih-Cardenas, Laura González-González, Raquel M. Melero-Fernández de Mera, Carlos Rodríguez-Martín, Javier Alonso, Enrique Fernández-Tabanera, Laura García-García, Miguel Angel Moreno-Pelayo, Maria Iranzo-Martínez, Matias Morin
Publikováno v:
Cancers, Vol 13, Iss 3783, p 3783 (2021)
Cancers
Repisalud
Instituto de Salud Carlos III (ISCIII)
Volume 13
Issue 15
Cancers
Repisalud
Instituto de Salud Carlos III (ISCIII)
Volume 13
Issue 15
Simple Summary Ewing sarcoma is an aggressive tumor with still unacceptable survival rates, particularly in patients with metastatic disease and for which it is necessary to develop new and innovative therapies. These tumors are characterized by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b737ddb64d3c7beaa0fdd99b7c736d3
https://www.mdpi.com/2072-6694/13/15/3783
https://www.mdpi.com/2072-6694/13/15/3783
Autor:
Guang‐Jie Zhu, Yuhang Huang, Linqing Zhang, Keji Yan, Cui Qiu, Yihan He, Qing Liu, Chengwen Zhu, Matías Morín, Miguel Ángel Moreno‐Pelayo, Min‐Sheng Zhu, Xin Cao, Han Zhou, Xiaoyun Qian, Zhigang Xu, Jie Chen, Xia Gao, Guoqiang Wan
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp 1-20 (2023)
Abstract Cingulin (CGN) is a cytoskeleton‐associated protein localized at the apical junctions of epithelial cells. CGN interacts with major cytoskeletal filaments and regulates RhoA activity. However, physiological roles of CGN in development and
Externí odkaz:
https://doaj.org/article/8e775ad618694efebba7ec761a5f62d4
Autor:
María Lachgar-Ruiz, Matías Morín, Elisa Martelletti, Neil J. Ingham, Lorenzo Preite, Morag A. Lewis, Luciana Santos Serrão de Castro, Karen P. Steel, Miguel Ángel Moreno-Pelayo
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 8 (2023)
Externí odkaz:
https://doaj.org/article/c6c51b6550434d268a2800313a33a8f2
Autor:
Sara Fañanas-Baquero, Matías Morín, Sergio Fernández, Isabel Ojeda-Perez, Mercedes Dessy-Rodriguez, Miruna Giurgiu, Juan A. Bueren, Miguel Angel Moreno-Pelayo, Jose Carlos Segovia, Oscar Quintana-Bustamante
Publikováno v:
Frontiers in Genome Editing, Vol 5 (2023)
Pyruvate kinase deficiency (PKD) is an autosomal recessive disorder caused by mutations in the PKLR gene. PKD-erythroid cells suffer from an energy imbalance caused by a reduction of erythroid pyruvate kinase (RPK) enzyme activity. PKD is associated
Externí odkaz:
https://doaj.org/article/9304ddc2d19f4b5a87e0230bce6ecc47
Autor:
María Domínguez-Ruiz, Laura Ruiz-Palmero, Paula I. Buonfiglio, Irene García-Vaquero, Elena Gómez-Rosas, Marina Goñi, Manuela Villamar, Matías Morín, Miguel A. Moreno-Pelayo, Ana B. Elgoyhen, Francisco J. del Castillo, Viviana Dalamón, Ignacio del Castillo
Publikováno v:
Biomedicines, Vol 11, Iss 11, p 2943 (2023)
Non-syndromic hearing impairment (NSHI) is a very heterogeneous genetic condition, involving over 130 genes. Mutations in GJB2, encoding connexin-26, are a major cause of NSHI (the DFNB1 type), but few other genes have significant epidemiological con
Externí odkaz:
https://doaj.org/article/992bbf9bae834364a262f8b6f33463a6
Autor:
Nadia Madrid-Elena, Sergio Serrano-Villar, Carolina Gutiérrez, Beatriz Sastre, Matías Morín, Laura Luna, Laura Martín, Javier Santoyo-López, María Rosa López-Huertas, Elena Moreno, María Laura García-Bermejo, Miguel Ángel Moreno-Pelayo, Santiago Moreno
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
miRNAs dictate relevant virus-host interactions, offering new avenues for interventions to achieve an HIV remission. We aimed to enhance HIV-specific cytotoxic responses—a hallmark of natural HIV control— by miRNA modulation in T cells. We recrui
Externí odkaz:
https://doaj.org/article/3e31d5bb5f1a41808bf99a068631a31a
Publikováno v:
Cytoskeleton and Human Disease ISBN: 9781617797873
Hearing loss comprises a group of disorders with great social implications. During the past decade, tremendous progress has been made in the investigation of hereditary hearing impairment, especially in the nonsyndromic forms, in which the hearing de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1cda449475211093b539cad91ddb07c
https://doi.org/10.1007/978-1-61779-788-0_9
https://doi.org/10.1007/978-1-61779-788-0_9
Autor:
María Rosa López-Huertas, Matías Morín, Nadia Madrid-Elena, Carolina Gutiérrez, Laura Jiménez-Tormo, Javier Santoyo, Francisco Sanz-Rodríguez, Miguel Ángel Moreno Pelayo, Laura García Bermejo, Santiago Moreno
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 17, Iss , Pp 323-336 (2019)
HIV remains incurable because of viral persistence in latent reservoirs that are inaccessible to antiretroviral therapy. A potential curative strategy is to reactivate viral gene expression in latently infected cells. However, no drug so far has prov
Externí odkaz:
https://doaj.org/article/e4eef784a2814956b150029ec0a01d71