Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Matias J. Caldez"'
Autor:
Slim Mzoughi, Jia Yi Fong, David Papadopoli, Cheryl M. Koh, Laura Hulea, Paolo Pigini, Federico Di Tullio, Giuseppe Andreacchio, Michal Marek Hoppe, Heike Wollmann, Diana Low, Matias J. Caldez, Yanfen Peng, Denis Torre, Julia N. Zhao, Oro Uchenunu, Gabriele Varano, Corina-Mihaela Motofeanu, Manikandan Lakshmanan, Shun Xie Teo, Cheng Mun Wun, Giovanni Perini, Soo Yong Tan, Chee Bing Ong, Muthafar Al-Haddawi, Ravisankar Rajarethinam, Susan Swee-Shan Hue, Soon Thye Lim, Choon Kiat Ong, Dachuan Huang, Siok-Bian Ng, Emily Bernstein, Dan Hasson, Keng Boon Wee, Philipp Kaldis, Anand Jeyasekharan, David Dominguez-sola, Ivan Topisirovic, Ernesto Guccione
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The transcriptional regulator PRDM15 is expressed at low levels in normal tissues but overexpressed in B-cell lymphomas. Here, the authors show that PRDM15 depletion does not affect adult somatic cell homeostasis but leads to a metabolic crisis which
Externí odkaz:
https://doaj.org/article/9df5fd5400ec47e98903d3b9c0b42cbb
Autor:
Senthil Raja Jayapal, Chelsia Qiuxia Wang, Xavier Bisteau, Matias J. Caldez, Shuhui Lim, Vinay Tergaonkar, Motomi Osato, Philipp Kaldis
Publikováno v:
Haematologica, Vol 100, Iss 4 (2015)
Mouse knockouts of Cdk2 and Cdk4 are individually viable whereas the double knockouts are embryonic lethal due to heart defects, and this precludes the investigation of their overlapping roles in definitive hematopoiesis. Here we use a conditional kn
Externí odkaz:
https://doaj.org/article/926090a93b1f4415806bd2e65b8520b7
Autor:
Jin Rong Ow, Matias J Caldez, Gözde Zafer, Juat Chin Foo, Hong Yu Li, Soumita Ghosh, Heike Wollmann, Amaury Cazenave-Gassiot, Chee Bing Ong, Markus R Wenk, Weiping Han, Hyungwon Choi, Philipp Kaldis
Publikováno v:
eLife, Vol 9 (2020)
Cell cycle progression and lipid metabolism are well-coordinated processes required for proper cell proliferation. In liver diseases that arise from dysregulated lipid metabolism, hepatocyte proliferation is diminished. To study the outcome of CDK1 l
Externí odkaz:
https://doaj.org/article/800dcd51bf63414c82eae688da8bc038
Autor:
Heike Wollmann, David Papadopoli, Ravisankar Rajarethinam, Giovanni Perini, Michal Marek Hoppe, Laura Hulea, Soo Yong Tan, Emily Bernstein, Susan Swee Shan Hue, Choon Kiat Ong, Siok Bian Ng, Soon Thye Lim, Slim Mzoughi, Cheryl M. Koh, Ivan Topisirovic, Federico Di Tullio, Manikandan Lakshmanan, Corina Mihaela Motofeanu, Ernesto Guccione, Cheng Mun Wun, Oro Uchenunu, Chee Bing Ong, David Dominguez-Sola, Shun Xie Teo, Diana Low, Giuseppe Andreacchio, Gabriele Varano, Dachuan Huang, Muthafar Al-Haddawi, Paolo Pigini, Denis Torre, Y Peng, Anand D. Jeyasekharan, Julia N. Zhao, Philipp Kaldis, Jia Yi Fong, Matias J. Caldez, Keng Boon Wee, Dan Hasson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
PRDM (PRDI-BF1 and RIZ homology domain containing) family members are sequence-specific transcriptional regulators involved in cell identity and fate determination, often dysregulated in cancer. The PRDM15 gene is of particular interest, given its lo
Autor:
Juat Chin Foo, Jin Rong Ow, Matias J. Caldez, Amaury Cazenave-Gassiot, Hyungwon Choi, Gözde Zafer, Chee Bing Ong, Soumita Ghosh, Weiping Han, Philipp Kaldis, Heike Wollmann, Markus R. Wenk, Hong Yu Li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8525ba05a72856f440936c75e396f8b
https://doi.org/10.7554/elife.63835.sa2
https://doi.org/10.7554/elife.63835.sa2
Therapeutic targeting of the mitochondrial one-carbon pathway: perspectives, pitfalls, and potential
Publikováno v:
Oncogene. 40(13)
Most of the drugs currently prescribed for cancer treatment are riddled with substantial side effects. In order to develop more effective and specific strategies to treat cancer, it is of importance to understand the biology of drug targets, particul
Autor:
Jianliang Xu, Safiah Mohamed Ali, Wan Lu Woo, P. Jaya Kausalya, Noémi Van Hul, Philipp Kaldis, Walter Hunziker, Matias J. Caldez, Alicia Ghia Min Ong, Shiyi Xu
BACKGROUND & AIMSTight junctions (TJs) establish tissue barriers that maintain osmotic homeostasis and, in the liver, isolate bile flow from the blood circulation. ZO-2/Tjp2 is a scaffold protein that tethers TJ transmembrane proteins to the actin cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba09ad8335d27441657891aa653bad4f
Autor:
Sudipto Roy, Noémi van Hul, Janine Altmüller, Hyungwon Choi, Nur'Ain Binte Ali, Xavier Bisteau, Shuhui Lim, Christian Windpassinger, Stéphane Blouin, Verena Rupp, Carine Bonnard, Franz Grill, Byrappa Venkatesh, Bruno Reversade, Rudolf Ganger, Vincenzo Coppola, S. Zakiah A. Talib, Klaus Klaushofer, Majid Alfadhel, Gökhan Yigit, Farid Ben Chehida, Paul Roschger, Ali Al Kaissi, Matias J. Caldez, Umut Altunoglu, Bernd Wollnik, Hülya Kayserili, Lionel Van Maldergem, Alvin Yu Jin Ng, Sameh A. Youssef, Lino Tessarollo, Katharina M. Roetzer, Hao Lu, Philipp Kaldis, Juliette Piard, Alain de Bruin, Sumanty Tohari
Publikováno v:
American Journal of Human Genetics
American journal of human genetics, 101(3), 391-403. Cell Press
American Journal of Human Genetics, 101(3), 391. Cell Press
American journal of human genetics, 101(3), 391-403. Cell Press
American Journal of Human Genetics, 101(3), 391. Cell Press
In five separate families, we identified nine individuals affected by a previously unidentified syndrome characterized by growth retardation, spine malformation, facial dysmorphisms, and developmental delays. Using homozygosity mapping, array CGH, an
Autor:
Gan Xiao Xuan, Xavier Bisteau, Heather Yin Kuan Ang, Philipp Kaldis, Weimiao Yu, Motomi Osato, Matias J. Caldez, Chelsia Qiuxia Wang, Bing Lim, Vinay Tergaonkar, Senthil Raja Jayapal
Publikováno v:
Cell Cycle. 15:3070-3081
Cyclin A2 is an essential gene for development and in haematopoietic stem cells and therefore its functions in definitive erythropoiesis have not been investigated. We have ablated cyclin A2 in committed erythroid progenitors in vivo using erythropoi
Autor:
Kia Ngee Low, Igor V. Kurochkin, Christine M. F. Goh, Matias J. Caldez, Vincenzo Coppola, Philipp Kaldis, Frank Eisenhaber, Yoganathan Kanagasundaram, Sebastian Maurer-Stroh, Hyungwon Choi, Lakshmi Gopinathan, Elisabeth Pfeiffenberger, Yang Lay Kien, Oliver S. Jones, Joanna Niska-Blakie, Chee Bing Ong, Lino Tessarollo
Publikováno v:
Cellular and Molecular Life Sciences
SUGCT (C7orf10) is a mitochondrial enzyme that synthesizes glutaryl-CoA from glutarate in tryptophan and lysine catabolism, but it has not been studied in vivo. Although mutations in Sugct lead to Glutaric Aciduria Type 3 disease in humans, patients