Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Matias A. Ávila"'
Autor:
Maria Arechederra, Maria Rullán, Daniel Oyón, Matias A. Ávila, Jesús M. Urman, Carmen Berasain
Publikováno v:
Exploration of Digestive Diseases, Vol 3, Iss 1, Pp 5-21 (2024)
Hunting for tumoral material in body fluids, traditionally in blood, the so-called liquid biopsy is set to revolutionize the diagnosis and management of oncological patients. However, other biofluids can also be considered as alternative sources of b
Externí odkaz:
https://doaj.org/article/09fd70e8623344b0845f7f6c5c210d6b
Publikováno v:
Molecular Oncology, Vol 18, Iss 9, Pp 2107-2110 (2024)
Rewiring of cellular metabolism is now fully recognized as a hallmark of cancer. Tumor cells reprogram metabolic pathways to meet the energetic and macromolecular demands to support unrestricted growth and survival under unfavorable conditions. It is
Externí odkaz:
https://doaj.org/article/4357e0c3e3124af3bb2300de6cdfa96b
Autor:
Maitane Asensio, Oscar Briz, Elisa Herraez, Laura Perez-Silva, Ricardo Espinosa-Escudero, Diego Bueno-Sacristan, Ana Peleteiro-Vigil, Helen Hammer, Oliver Pötz, Onat Kadioglu, Jesus M. Banales, Maria L. Martinez-Chantar, Matias A. Avila, Rocio I.R. Macias, Thomas Efferth, Jose J.G. Marin, Elisa Lozano
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117533- (2024)
Aims: Drug export through ABC proteins hinders cancer response to chemotherapy. Here, we have evaluated the relevance of MRP3 (ABCC3) in cholangiocarcinoma (CCA) as a potential target to overcome drug resistance. Methods: Gene expression was analyzed
Externí odkaz:
https://doaj.org/article/0203ec3ee8bd4fc3ac082125978b51ae
Autor:
Carla Rojo, María Gárate-Rascón, Miriam Recalde, Ane Álava, María Elizalde, María Azkona, Iratxe Aldabe, Elisabet Guruceaga, Amaya López-Pascual, M Ujue Latasa, Bruno Sangro, Maite G. Fernández-Barrena, Matías A. Ávila, María Arechederra, Carmen Berasain
Publikováno v:
JHEP Reports, Vol 6, Iss 8, Pp 101118- (2024)
Background & Aims: The homeostasis of the cellular transcriptome depends on transcription and splicing mechanisms. Moreover, the fidelity of gene expression, essential to preserve cellular identity and function is secured by different quality control
Externí odkaz:
https://doaj.org/article/839678c118424464b7ef2ce1b0908674
Autor:
Natalia Pydyn, Anna Ferenc, Katarzyna Trzos, Ewelina Pospiech, Mateusz Wilamowski, Olga Mucha, Piotr Major, Justyna Kadluczka, Pedro M. Rodrigues, Jesus M. Banales, Jose M. Herranz, Matias A. Avila, Tomasz Hutsch, Piotr Malczak, Dorota Radkowiak, Andrzej Budzynski, Jolanta Jura, Jerzy Kotlinowski
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 6, Pp 887-906 (2024)
Background & Aims: Hepatic fibrosis is characterized by enhanced deposition of extracellular matrix (ECM), which results from the wound healing response to chronic, repeated injury of any etiology. Upon injury, hepatic stellate cells (HSCs) activate
Externí odkaz:
https://doaj.org/article/a8639a414f0d4d65bfedfeb983af94c3
Autor:
Sofia Lachiondo-Ortega, Claudia M. Rejano-Gordillo, Jorge Simon, Fernando Lopitz-Otsoa, Teresa C. Delgado, Krystyna Mazan-Mamczarz, Naroa Goikoetxea-Usandizaga, L. Estefanía Zapata-Pavas, Ana García-del Río, Pietro Guerra, Patricia Peña-Sanfélix, Natalia Hermán-Sánchez, Ruba Al-Abdulla, Carmen Fernandez-Rodríguez, Mikel Azkargorta, Alejandro Velázquez-Cruz, Joris Guyon, César Martín, Juan Diego Zalamea, Leire Egia-Mendikute, Arantza Sanz-Parra, Marina Serrano-Maciá, Irene González-Recio, Monika Gonzalez-Lopez, Luis Alfonso Martínez-Cruz, Patrizia Pontisso, Ana M. Aransay, Rosa Barrio, James D. Sutherland, Nicola G.A. Abrescia, Félix Elortza, Amaia Lujambio, Jesus M. Banales, Raúl M. Luque, Manuel D. Gahete, Asís Palazón, Matias A. Avila, Jose J. G. Marin, Supriyo De, Thomas Daubon, Antonio Díaz-Quintana, Irene Díaz-Moreno, Myriam Gorospe, Manuel S. Rodríguez, María Luz Martínez-Chantar
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113924- (2024)
Summary: The posttranslational modification of proteins critically influences many biological processes and is a key mechanism that regulates the function of the RNA-binding protein Hu antigen R (HuR), a hub in liver cancer. Here, we show that HuR is
Externí odkaz:
https://doaj.org/article/ac05448b67bf43d08eefd6737eb5e995
Autor:
Sergio Barace, Eva Santamaría, Stefany Infante, Sara Arcelus, Jesus De La Fuente, Enrique Goñi, Ibon Tamayo, Idoia Ochoa, Miguel Sogbe, Bruno Sangro, Mikel Hernaez, Matias A. Avila, Josepmaria Argemi
Publikováno v:
Biomolecules, Vol 14, Iss 6, p 653 (2024)
Whole-tissue transcriptomic analyses have been helpful to characterize molecular subtypes of hepatocellular carcinoma (HCC). Metabolic subtypes of human HCC have been defined, yet whether these different metabolic classes are clinically relevant or d
Externí odkaz:
https://doaj.org/article/849503fa0ca248918b9f5150dce46864
Autor:
Kang Zheng, Fengjie Hao, Sandra Medrano-Garcia, Chaobo Chen, Feifei Guo, Laura Morán-Blanco, Sandra Rodríguez-Perales, Raúl Torres-Ruiz, María Isabel Peligros, Javier Vaquero, Rafael Bañares, Manuel Gómez del Moral, José R. Regueiro, Eduardo Martínez-Naves, Mohamed Ramadan Mohamed, Rocío Gallego-Durán, Douglas Maya, Javier Ampuero, Manuel Romero-Gómez, Albert Gilbert-Ramos, Sergi Guixé-Muntet, Anabel Fernández-Iglesias, Jordi Gracia-Sancho, Mar Coll, Isabel Graupera, Pere Ginès, Andreea Ciudin, Jesús Rivera-Esteban, Juan M. Pericàs, María Dolores Frutos, Bruno Ramos Molina, José María Herranz, Matías A. Ávila, Yulia A. Nevzorova, Edgar Fernández-Malavé, Francisco Javier Cubero
Publikováno v:
Cell Death and Disease, Vol 14, Iss 8, Pp 1-12 (2023)
Abstract Progressive hepatic damage and fibrosis are major features of chronic liver diseases of different etiology, yet the underlying molecular mechanisms remain to be fully defined. N-RAS, a member of the RAS family of small guanine nucleotide-bin
Externí odkaz:
https://doaj.org/article/01a591f664c741c59cc9c983321052fd
Autor:
Rubén Rodríguez-Agudo, Irene González-Recio, Marina Serrano-Maciá, Miren Bravo, Petar Petrov, Delia Blaya, Jose María Herranz, María Mercado-Gómez, Claudia María Rejano-Gordillo, Sofía Lachiondo-Ortega, Clàudia Gil-Pitarch, Mikel Azkargorta, Sebastiaan Martijn Van Liempd, Luis Alfonso Martinez-Cruz, A.L. Simão, Félix Elortza, César Martín, Yulia A. Nevzorova, Francisco Javier Cubero, Teresa C. Delgado, Josepmaria Argemi, Ramón Bataller, Kristina Schoonjans, Jesús M. Banales, Rui E. Castro, Pau Sancho-Bru, Matías A. Avila, Josep Julve, Ramiro Jover, Jon Mabe, Jorge Simon, Naroa Goikoetxea-Usandizaga, María L. Martínez-Chantar
Publikováno v:
JHEP Reports, Vol 6, Iss 1, Pp 100918- (2024)
Background & Aims: Current therapies for the treatment of alcohol-related liver disease (ALD) have proven largely ineffective. Patients relapse and the disease progresses even after liver transplantation. Altered epigenetic mechanisms are characteris
Externí odkaz:
https://doaj.org/article/2c731ca37cd542a581f44cda78d386a6
Autor:
Irene González-Recio, Jorge Simón, Naroa Goikoetxea-Usandizaga, Marina Serrano-Maciá, Maria Mercado-Gómez, Rubén Rodríguez-Agudo, Sofía Lachiondo-Ortega, Clàudia Gil-Pitarch, Carmen Fernández-Rodríguez, Donatello Castellana, Maria U. Latasa, Leticia Abecia, Juan Anguita, Teresa C. Delgado, Paula Iruzubieta, Javier Crespo, Serge Hardy, Petar D. Petrov, Ramiro Jover, Matías A. Avila, César Martín, Ute Schaeper, Michel L. Tremblay, James W. Dear, Steven Masson, Misti Vanette McCain, Helen L. Reeves, Raul J. Andrade, M. Isabel Lucena, Daniela Buccella, Luis Alfonso Martínez-Cruz, Maria L Martínez-Chantar
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Drug induced liver injury (DILI) is an important cause acute liver failure. Here the authors report that serum Mg2+ serum levels decrease in patients with DILI as well as in preclinical animal models treated with acetaminophen overdose, and that earl
Externí odkaz:
https://doaj.org/article/2a4712610b65483485edb1bca7bf6fb0