Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Matias, Kinnunen"'
Autor:
Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Transcription factors (TFs) interact with several other proteins in the process of transcriptional regulation. Here the authors identify 6703 and 1536 protein–protein interactions for 109 different human TFs through BioID and AP-MS analyses, respec
Externí odkaz:
https://doaj.org/article/67c33cf493234878a8d14411ff4708ab
Autor:
Frederik Staels, Kerstin De Keukeleere, Matias Kinnunen, Salla Keskitalo, Flaminia Lorenzetti, Michiel Vanmeert, Teresa Prezzemolo, Emanuela Pasciuto, Eveline Lescrinier, Xavier Bossuyt, Margaux Gerbaux, Mathijs Willemsen, Julika Neumann, Sien Van Loo, Anniek Corveleyn, Karen Willekens, Ingeborg Stalmans, Isabelle Meyts, Adrian Liston, Stephanie Humblet-Baron, Mikko Seppänen, Markku Varjosalo, Rik Schrijvers
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
NFKB1 haploinsufficiengcy was first described in 2015 in three families with common variable immunodeficiency (CVID), presenting heterogeneously with symptoms of increased infectious susceptibility, skin lesions, malignant lymphoproliferation and aut
Externí odkaz:
https://doaj.org/article/85f7fb4050f842d3bfe2feb08301f40d
Autor:
Manfred Fliegauf, Matias Kinnunen, Sara Posadas-Cantera, Nadezhda Camacho-Ordonez, Hassan Abolhassani, Laia Alsina, Faranaz Atschekzei, Delfien J. Bogaert, Siobhan O. Burns, Joseph A. Church, Gregor Dückers, Alexandra F. Freeman, Lennart Hammarström, Leif Gunnar Hanitsch, Tessa Kerre, Robin Kobbe, Svetlana O. Sharapova, Kathrin Siepermann, Carsten Speckmann, Sophie Steiner, Nisha Verma, Jolan E. Walter, Emma Westermann-Clark, Sigune Goldacker, Klaus Warnatz, Markku Varjosalo, Bodo Grimbacher
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Most of the currently known heterozygous pathogenic NFKB1 (Nuclear factor kappa B subunit 1) variants comprise deleterious defects such as severe truncations, internal deletions, and frameshift variants. Collectively, these represent the most frequen
Externí odkaz:
https://doaj.org/article/d9245bd92ea94ce499ebc30f5a9fab14
Autor:
Mika J. Välimäki, Robert S. Leigh, Sini M. Kinnunen, Alexander R. March, Ana Hernández de Sande, Matias Kinnunen, Markku Varjosalo, Merja Heinäniemi, Bogac L. Kaynak, Heikki Ruskoaho
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-18 (2021)
Abstract Background Pharmacological modulation of cell fate decisions and developmental gene regulatory networks holds promise for the treatment of heart failure. Compounds that target tissue-specific transcription factors could overcome non-specific
Externí odkaz:
https://doaj.org/article/614c3e9ddc044f04a27581297b6207ab
Autor:
Jonna Saarimäki-Vire, Diego Balboa, Mark A. Russell, Juha Saarikettu, Matias Kinnunen, Salla Keskitalo, Amrinder Malhi, Cristina Valensisi, Colin Andrus, Solja Eurola, Heli Grym, Jarkko Ustinov, Kirmo Wartiovaara, R. David Hawkins, Olli Silvennoinen, Markku Varjosalo, Noel G. Morgan, Timo Otonkoski
Publikováno v:
Cell Reports, Vol 19, Iss 2, Pp 281-294 (2017)
Summary: Activating germline mutations in STAT3 were recently identified as a cause of neonatal diabetes mellitus associated with beta-cell autoimmunity. We have investigated the effect of an activating mutation, STAT3K392R, on pancreatic development
Externí odkaz:
https://doaj.org/article/ec346f9834cd42bbb148c06590ce525e
Autor:
Manfred, Fliegauf, Matias, Kinnunen, Sara, Posadas-Cantera, Nadezhda, Camacho-Ordonez, Hassan, Abolhassani, Laia, Alsina, Faranaz, Atschekzei, Delfien J, Bogaert, Siobhan O, Burns, Joseph A, Church, Gregor, Dückers, Alexandra F, Freeman, Lennart, Hammarström, Leif Gunnar, Hanitsch, Tessa, Kerre, Robin, Kobbe, Svetlana O, Sharapova, Kathrin, Siepermann, Carsten, Speckmann, Sophie, Steiner, Nisha, Verma, Jolan E, Walter, Emma, Westermann-Clark, Sigune, Goldacker, Klaus, Warnatz, Markku, Varjosalo, Bodo, Grimbacher
Publikováno v:
Frontiers in immunology. 13
Most of the currently known heterozygous pathogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9c3bef1d4c7ba0a753a16c615d3b6f22
https://pubmed.ncbi.nlm.nih.gov/36105815
https://pubmed.ncbi.nlm.nih.gov/36105815
Publikováno v:
Cancer Research. 83:LB006-LB006
Chromosomal translocations creating fusion genes are among the most common mutation class of known cancer genes, and they have long been identified as driver mutations in certain types of cancer. Recently, oncogenic fusion genes (oncofusions, OFs) ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8591cda34dcc4b3fe3190420572cff5
https://doi.org/10.1158/1538-7445.am2023-lb006
https://doi.org/10.1158/1538-7445.am2023-lb006
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e355d98ebf3aff6de107a419e2936357
https://doi.org/10.1096/fasebj.2022.36.s1.l7611
https://doi.org/10.1096/fasebj.2022.36.s1.l7611
Autor:
Iivo, Hetemäki, Meri, Kaustio, Matias, Kinnunen, Nelli, Heikkilä, Salla, Keskitalo, Kirsten, Nowlan, Simo, Miettinen, Joona, Sarkkinen, Virpi, Glumoff, Noora, Andersson, Kaisa, Kettunen, Reetta, Vanhanen, Katariina, Nurmi, Kari K, Eklund, Johannes, Dunkel, Mikko I, Mäyränpää, Heinrich, Schlums, T Petteri, Arstila, Kai, Kisand, Yenan T, Bryceson, Pärt, Peterson, Ulla, Otava, Jaana, Syrjänen, Janna, Saarela, Markku, Varjosalo, Eliisa, Kekäläinen
Publikováno v:
Science immunology. 6(65)
The Ikaros family transcription factors regulate lymphocyte development. Loss-of-function variants in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::653382fc70b384af21c884f81f1d52d3
https://pubmed.ncbi.nlm.nih.gov/34826260
https://pubmed.ncbi.nlm.nih.gov/34826260