Výsledky vyhledávání - "Matias, Dino"

Human neurons derived from induced pluripotent stem cells: a platform for screening compounds to treat Gaucher´s disease and Parkinson's disease

Autor: Matias, Dino Emanuel Santos

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

A doença de Gaucher (Gaucher disease – GD) é a doença lisossomal com maior taxa incidência em todo o mundo (Mistry et al., 2017). As doenças de armazenamento lisossomal, são um grupo de doenças metabólicas hereditárias caracterizadas pela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::fba19cda81ab178a034db317cbba9043

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Highly pH-Responsive Pharmacological Chaperones for Mutant Glycosidase Enhancement

Autor: Mena-Barragán, Teresa, Narita, Aya, Matias, Dino, Tiscornia, Gustavo, Nanba, Eiji, Ohno, Kousaku, Suzuki, Yoshiyuki, Higaki, Katsumi, García-Fernández, José Manuel, Ortiz-Mellet, Carmen

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

A general approach is reported for the design of small-molecule competitive inhibitors of lysosomal glycosidases programmed to 1) promote correct folding of mutant enzymes at the endoplasmic reticulum, 2) facilitate trafficking, and 3) undergo dissoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4ae861575747cedd147f2c9127fe5982
http://hdl.handle.net/10261/123024

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Development of a Piggybac based direct reprogramming system for derivation of integration free induced pluripotent stem cells

Autor: Matias, Dino Emanuel Santos

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Induced pluripotent stem cells (iPSc) have great potential for applications in regenerative medicine, disease modeling and basic research. Several methods have been developed for their derivation. The original method of Takahashi and Yamanaka involve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::002b9c324bee2d47560240e236b84b30
https://hdl.handle.net/10400.1/5974

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