Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Matia B. Solomon"'
Novel molecular mechanisms in Alzheimer’s disease: The potential role of DEK in disease pathogenesis
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Alzheimer’s disease and age-related dementias (AD/ADRD) are debilitating diseases that exact a significant physical, emotional, cognitive, and financial toll on the individual and their social network. While genetic risk factors for early-onset AD
Externí odkaz:
https://doaj.org/article/1ed284eeac754aa995a10259e497ce67
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Alzheimer’s disease (AD) is the most common cause of dementia and is characterized by the buildup of β-amyloid plaques and neurofibrillary Tau tangles. This leads to decreased synaptic efficacy, cell death, and, consequently, brain atrophy in pati
Externí odkaz:
https://doaj.org/article/160801fca72640c28af0639eca3aaeef
Publikováno v:
Journal of Child and Family Studies.
Autor:
Allie N. Greene, Elizabeth T. Nguyen, Aditi Paranjpe, Adam Lane, Lisa M. Privette Vinnedge, Matia B. Solomon
Publikováno v:
The European journal of neuroscienceREFERENCES. 56(6)
DEK, a chromatin-remodelling phosphoprotein, is associated with various functions and biological pathways in the periphery, including inflammation, oncogenesis, DNA repair, and transcriptional regulation. We recently identified an association between
Autor:
null Allie N. Greene, null Elizabeth T. Nguyen, null Aditi Paranjpe, null Adam Lane, null Lisa M. Privette Vinnedge, null Matia B. Solomon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a562f0f2390662fa804137654890282b
https://doi.org/10.1111/ejn.15791/v3/response1
https://doi.org/10.1111/ejn.15791/v3/response1
Publikováno v:
Alzheimer's & Dementia. 17
Autor:
Jody L. Caldwell, Valentina Ghisays, Joshua Streicher, Matia B. Solomon, Christina M. Estrada, Elizabeth T. Nguyen
Publikováno v:
Hormones and Behavior. 98:33-44
Declining estradiol (E2), as occurs during menopause, increases risk for obesity and psychopathology (i.e., depression, anxiety). E2 modulates mood and energy homeostasis via binding to estrogen receptors (ER) in the brain. The often comorbid and bid
Autor:
Christina M. Estrada, Matia B. Solomon, Valentina Ghisays, Joshua Streicher, Ana Franco-Villanueva, Nicholas A. Pease, Elizabeth T. Nguyen, Lisa M. Privette Vinnedge, Maureen Fitzgerald
Publikováno v:
Neuroscience. 371:254-267
DEK, a chromatin-remodeling gene expressed in most human tissues, is known for its role in cancer biology and autoimmune diseases. DEK depletion in vitro reduces cellular proliferation, induces DNA damage subsequently leading to apoptosis, and down-r
Autor:
Matia B. Solomon, Valentina Ghisays, Nikolaus J. Balmer, Christina M. Estrada, Joshua V Streicher, Jody L. Caldwell, Elizabeth T. Nguyen
Publikováno v:
Behavioural Brain Research. 336:99-110
Depression is commonly associated with hypothalamic-pituitary adrenal (HPA) axis dysfunction that primarily manifests as aberrant glucocorticoid secretion. Glucocorticoids act on Type I mineralocorticoid (MR) and Type II glucocorticoid receptors (GR)
Autor:
Valentina Ghisays, Christina M. Estrada, Sarah Berman, Joshua Streicher, Aynara C. Wulsin, Matia B. Solomon, Jody L. Caldwell, Elizabeth T. Nguyen
Publikováno v:
Physiology & Behavior. 178:82-92
Aberrant glucocorticoid secretion is implicated in the pathophysiology of stress-related disorders (i.e., depression, anxiety). Glucocorticoids exert biological effects via mineralocorticoid (MR) and glucocorticoid (GR) receptors. Previous data from