Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Mathy Froeyen"'
Autor:
Tom Grisez, Nitha Panikkassery Ravi, Mathy Froeyen, Dominique Schols, Luc Van Meervelt, Steven De Jonghe, Wim Dehaen
Publikováno v:
Molecules, Vol 29, Iss 5, p 954 (2024)
Disubstituted isothiazolo[4,3-b]pyridines are known inhibitors of cyclin G-associated kinase. Since 3-substituted-7-aryl-isothiazolo[4,3-b]pyridines remain elusive, a strategy was established to prepare this chemotype, starting from 2,4-dichloro-3-ni
Externí odkaz:
https://doaj.org/article/6adfaa32270c44a1bcf40a26f955d7cb
Autor:
Yanlin Jian, Martijn D. P. Risseeuw, Mathy Froeyen, Lijun Song, Davie Cappoen, Paul Cos, Hélène Munier-Lehmann, Serge van Calenbergh
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1730-1739 (2019)
A series of readily accessible 1-(piperidin-3-yl)thymine amides was designed, synthesised and evaluated as Mycobacterium tuberculosis TMPK (MtbTMPK) inhibitors. In line with the modelling results, most inhibitors showed reasonable MtbTMPK inhibitory
Externí odkaz:
https://doaj.org/article/60a10e54b7c64ecbbe4411d5e94387b7
Autor:
Joren Guillaume, Jing Wang, Jonas Janssens, Soumya G. Remesh, Martijn D. P. Risseeuw, Tine Decruy, Mathy Froeyen, Dirk Elewaut, Dirk M. Zajonc, Serge Van Calenbergh
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-18 (2017)
Abstract Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a synthetic α-galactosylceramide, they produce a vast amount of cytokines. Here we presen
Externí odkaz:
https://doaj.org/article/b6242e5fce344e1e9535e44bda9ee7ff
Autor:
Simone Musiu, Yunierkis Perez Castillo, Alexandra Muigg, Gerhard Pürstinger, Pieter Leyssen, Mathy Froeyen, Johan Neyts, Jan Paeshuyse
Publikováno v:
Molecules, Vol 25, Iss 6, p 1283 (2020)
The bovine viral diarrhea virus (BVDV), a pestivirus from the family of Flaviviridae is ubiquitous and causes a range of clinical manifestations in livestock, mainly cattle. Two quinolinecarboxamide analogues were identified in a CPE-based screening
Externí odkaz:
https://doaj.org/article/9c70290954794af795ea812db5291b3c
Autor:
Akkaladevi Venkatesham, Dhuldeo Kachare, Guy Schepers, Jef Rozenski, Mathy Froeyen, Arthur Van Aerschot
Publikováno v:
Molecules, Vol 20, Iss 3, Pp 4020-4041 (2015)
In further study of our series of six-membered ring-containing nucleic acids, different 1',3'-di-O-methyl altropyranoside nucleoside analogs (DMANA) were synthesized comprising all four base moieties, adenine, cytosine, uracil and guanine. Following
Externí odkaz:
https://doaj.org/article/a3fe33227a894b2387addbb981237870
Autor:
Gaston H Vondenhoff, Ksenia Pugach, Bharat Gadakh, Laurence Carlier, Jef Rozenski, Mathy Froeyen, Konstantin Severinov, Arthur Van Aerschot
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79234 (2013)
Microcin C analogues were recently envisaged as important compounds for the development of novel antibiotics. Two issues that may pose problems to these potential antibiotics are possible acquisition of resistance through acetylation and in vivo inst
Externí odkaz:
https://doaj.org/article/3f70f20bc3884ecfad66def5a2ab4576
Autor:
Stephen D. Weeks, Piet Herdewijn, Vitor B. Pinheiro, Jamoliddin Razzokov, Annemie Bogaerts, Jef Rozenski, Guy Schepers, Mathy Froeyen, Michiel Vanmeert, Eveline Lescrinier, Muhammad Usman Mirza
Publikováno v:
Nucleic Acids Research
Nucleic acids research
Nucleic acids research
Xenobiotic nucleic acids (XNA) are nucleic acid analogues not present in nature that can be used for the storage of genetic information. In vivo XNA applications could be developed into novel biocontainment strategies, but are currently limited by th
Autor:
Rina Barouch-Bentov, Ling-Jie Gao, Piet Herdewijn, J.M. Elkins, Fiona J. Sorrell, Shirit Einav, Laura I. Prugar, Stefan Knapp, Steven De Jonghe, Jennifer M. Brannan, Danielle Dorosky, Mathy Froeyen, Sven Verdonck, John M. Dye, Szu-Yuan Pu
Publikováno v:
J Med Chem
There are currently no approved drugs for the treatment of emerging viral infections, such as dengue and Ebola. Adaptor-associated kinase 1 (AAK1) is a cellular serine-threonine protein kinase that functions as a key regulator of the clathrin-associa
Autor:
Piet Herdewijn, Shirit Einav, Mathy Froeyen, Belén Martínez-Gualda, Steven De Jonghe, Dominique Schols, Sirle Saul
Structural modifications at position 3 of the isothiazolo[4,3-b]pyridine scaffold afforded a new series of cyclin G-associated kinase (GAK) inhibitors. It was shown that the insertion of a carboxamide residue at position 3 of a phenyl or piperidinyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceefd3e717942a67bbc28acefcb424d7
https://lirias.kuleuven.be/handle/123456789/671097
https://lirias.kuleuven.be/handle/123456789/671097
Autor:
Kristina Lanko, Leen Delang, Liang Sun, Mathy Froeyen, Pieter Leyssen, Carmen Mirabelli, Johan Neyts
Publikováno v:
Antiviral Research
Vapendavir is a rhino/enterovirus inhibitor that targets a hydrophobic pocket in the viral capsid preventing the virus from entering the cell. We set out to study and compare the molecular mechanisms of resistance to vapendavir among clinically relev