Multidisciplinary docking, kinetics and X-ray crystallography studies of baicalein acting as a glycogen phosphorylase inhibitor and determination of its' potential against glioblastoma in cellular models.

Autor: Mathomes RT; School of Pharmacy & Biomedical Sciences, University of Central Lancashire, Preston, PR1 2HE, United Kingdom., Koulas SM; Department of Biochemistry & Biotechnology, University of Thessaly, Biopolis, 41500, Larissa, Greece., Tsialtas I; Department of Biochemistry & Biotechnology, University of Thessaly, Biopolis, 41500, Larissa, Greece., Stravodimos G; Department of Biochemistry & Biotechnology, University of Thessaly, Biopolis, 41500, Larissa, Greece., Welsby PJ; Department of Postgraduate Medical Education, Edge Hill University, Ormskirk, L39 4QP, United Kingdom., Psarra AG; Department of Biochemistry & Biotechnology, University of Thessaly, Biopolis, 41500, Larissa, Greece., Stasik I; School of Pharmacy & Biomedical Sciences, University of Central Lancashire, Preston, PR1 2HE, United Kingdom., Leonidas DD; Department of Biochemistry & Biotechnology, University of Thessaly, Biopolis, 41500, Larissa, Greece. Electronic address: ddleonidas@bio.uth.gr., Hayes JM; School of Pharmacy & Biomedical Sciences, University of Central Lancashire, Preston, PR1 2HE, United Kingdom. Electronic address: jhayes@uclan.ac.uk.

Publikováno v: Chemico-biological interactions [Chem Biol Interact] 2023 Sep 01; Vol. 382, pp. 110568. Date of Electronic Publication: 2023 Jun 03.

Identification of C -β-d-Glucopyranosyl Azole-Type Inhibitors of Glycogen Phosphorylase That Reduce Glycogenolysis in Hepatocytes: In Silico Design, Synthesis, in Vitro Kinetics, and ex Vivo Studies.

Autor: Barr D; School of Physical Sciences & Computing , University of Central Lancashire , Preston PR1 2HE , United Kingdom., Szennyes E; Department of Organic Chemistry , University of Debrecen , POB 400 , H-4002 Debrecen , Hungary., Bokor É; Department of Organic Chemistry , University of Debrecen , POB 400 , H-4002 Debrecen , Hungary., Al-Oanzi ZH; Institute of Cellular Medicine , Newcastle University , Newcastle upon Tyne NE2 4HH , United Kingdom., Moffatt C; Health & Life Sciences , De Montfort University , Gateway House , Leicester LE1 9BH , United Kingdom., Kun S; Department of Organic Chemistry , University of Debrecen , POB 400 , H-4002 Debrecen , Hungary., Docsa T; Department of Medical Chemistry, Medical and Health Science Centre , University of Debrecen , Egyetem tér 1 , H-4032 Debrecen , Hungary., Sipos Á; Department of Medical Chemistry, Medical and Health Science Centre , University of Debrecen , Egyetem tér 1 , H-4032 Debrecen , Hungary., Davies MP; School of Physical Sciences & Computing , University of Central Lancashire , Preston PR1 2HE , United Kingdom., Mathomes RT; School of Pharmacy & Biomedical Sciences , University of Central Lancashire , Preston PR1 2HE , United Kingdom., Snape TJ; School of Pharmacy & Biomedical Sciences , University of Central Lancashire , Preston PR1 2HE , United Kingdom., Agius L; Institute of Cellular Medicine , Newcastle University , Newcastle upon Tyne NE2 4HH , United Kingdom., Somsák L; Department of Organic Chemistry , University of Debrecen , POB 400 , H-4002 Debrecen , Hungary., Hayes JM; School of Pharmacy & Biomedical Sciences , University of Central Lancashire , Preston PR1 2HE , United Kingdom.

Publikováno v: ACS chemical biology [ACS Chem Biol] 2019 Jul 19; Vol. 14 (7), pp. 1460-1470. Date of Electronic Publication: 2019 Jun 19.