Synthesis and biological evaluation of 3-amino-, 3-alkoxy- and 3-aryloxy-6-(hetero)arylpyridazines as potent antitumor agents

Autor: Eric Léonel, Morgane Rousselle, Didier Dubreuil, Gervaise Loirand, Florian Dilasser, Rémy Le Guével, Erwan Le Gall, Muriel Pipelier, Vincent Sauzeau, Stéphane Sengmany, Jacques Lebreton, Mathilde Sitter, Thierry Martens

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2019, 29 (5), pp.755-760. ⟨10.1016/j.bmcl.2018.12.050⟩
Bioorganic and Medicinal Chemistry Letters, 2019, 29 (5), pp.755-760. ⟨10.1016/j.bmcl.2018.12.050⟩
Bioorganic & Medicinal Chemistry Letters
Bioorganic & Medicinal Chemistry Letters, 2019, 29 (5), pp.755-760. ⟨10.1016/j.bmcl.2018.12.050⟩

International audience; Various 3-amino-, 3-aryloxy- and alkoxy-6-arylpyridazines have been synthesized by an electrochemical reductive cross-coupling between 3-amino-, 3-aryloxy- or 3-alkoxy-6-chloropyridazines and aryl or heteroaryl halides. In vit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e35eb0e243984331307a465e5b00ad21
https://doi.org/10.1016/j.bmcl.2018.12.050