Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Mathilde R, Israel"'
Autor:
Sina Jami, Jennifer R. Deuis, Tabea Klasfauseweh, Xiaoyang Cheng, Sergey Kurdyukov, Felicity Chung, Andrei L. Okorokov, Shengnan Li, Jiangtao Zhang, Ben Cristofori-Armstrong, Mathilde R. Israel, Robert J. Ju, Samuel D. Robinson, Peng Zhao, Lotten Ragnarsson, Åsa Andersson, Poanna Tran, Vanessa Schendel, Kirsten L. McMahon, Hue N. T. Tran, Yanni K.-Y. Chin, Yifei Zhu, Junyu Liu, Theo Crawford, Saipriyaa Purushothamvasan, Abdella M. Habib, David A. Andersson, Lachlan D. Rash, John N. Wood, Jing Zhao, Samantha J. Stehbens, Mehdi Mobli, Andreas Leffler, Daohua Jiang, James J. Cox, Stephen G. Waxman, Sulayman D. Dib-Hajj, G. Gregory Neely, Thomas Durek, Irina Vetter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Voltage-gated sodium (NaV) channels are critical regulators of neuronal excitability and are targeted by many toxins that directly interact with the pore-forming α subunit, typically via extracellular loops of the voltage-sensing domains, o
Externí odkaz:
https://doaj.org/article/ef7fee6301d340c5b67edc494cc4b801
Autor:
Mathilde R. Israel, Thomas S. Dash, Stefanie N. Bothe, Samuel D. Robinson, Jennifer R. Deuis, David J. Craik, Angelika Lampert, Irina Vetter, Thomas Durek
Publikováno v:
Biomedicines, Vol 8, Iss 6, p 155 (2020)
NaV1.3 is a subtype of the voltage-gated sodium channel family. It has been implicated in the pathogenesis of neuropathic pain, although the contribution of this channel to neuronal excitability is not well understood. Tf2, a β-scorpion toxin previo
Externí odkaz:
https://doaj.org/article/6b1890e16f0b48d49c998f2612d6eab5
Autor:
David J. Craik, Christina I. Schroeder, Akello J. Agwa, Mathilde R. Israel, Alexander Mueller, Irina Vetter, Jennifer R. Deuis, Hue N. T. Tran, Kirsten L. McMahon, Poanna Tran
Publikováno v:
J Biol Chem
Huwentoxin-IV (HwTx-IV) is a gating modifier peptide toxin from spiders that has weak affinity for the lipid bilayer. As some gating modifier toxins have affinity for model lipid bilayers, a tripartite relationship among gating modifier toxins, volta
Autor:
Tabea, Klasfauseweh, Mathilde R, Israel, Lotten, Ragnarsson, James J, Cox, Thomas, Durek, David A, Carter, Andreas, Leffler, Irina, Vetter, Jennifer R, Deuis
Publikováno v:
European journal of pharmacology. 925
QX-314 is a quaternary permanently charged lidocaine derivative that inhibits voltage-gated sodium channels (Na
Autor:
Peng Zhao, Thomas Durek, Sulayman D. Dib-Hajj, Brian S. Tanaka, Mathilde R. Israel, David J. Craik, Irina Vetter, Samuel D. Robinson, Stephen G. Waxman, Panumart Thongyoo, Stuart M. Brierley, Jennifer R. Deuis, Joel Castro
Publikováno v:
The Journal of Physiology. 597:3751-3768
Key points: Voltage-gated sodium channels are critical for peripheral sensory neuron transduction and have been implicated in a number of painful and painless disorders. The β-scorpion toxin, Cn2, is selective for Na1.6 in dorsal root ganglion neuro
Autor:
Tabea Klasfauseweh, Mathilde R. Israel, Lotten Ragnarsson, James J. Cox, Thomas Durek, David A. Carter, Andreas Leffler, Irina Vetter, Jennifer R. Deuis
Publikováno v:
European Journal of Pharmacology. 925:175013
Autor:
Joana Menezes, Yuki Nomura, Camilla I. Svensson, Angelica Sandström, Stuart Bevan, Margot Maurer, Azar Baharpoor, Nisha Vastani, David Andersson, Alexandra Jurczak, Lisbet Haglund, Clive Gentry, Andreas Goebel, Mathilde R. Israel, Louisa Brieskorn, Diana Kadetoff, Emerson Krock, Carlos Morado Urbina, Ulku Cuhadar, Eva Kosek, Serena Sensi, Katalin Sandor, Jeanette Tour
Publikováno v:
The Journal of Clinical Investigation
JOURNAL OF CLINICAL INVESTIGATION
JOURNAL OF CLINICAL INVESTIGATION
Fibromyalgia syndrome (FMS) is a chronic pain condition characterized by widespread pain, augmented pain sensitivity to mechanical pressure and cold temperatures (1–4), as well as fatigue and emotional distress (5–7). The prevalence of FMS is at
Autor:
Mathilde R. Israel, Volker Herzig, Glenn F. King, Ben Cristofori-Armstrong, Irina Vetter, Samantha A. Nixon
Publikováno v:
Biochemical Pharmacology
Graphical abstract
Venomous animals have evolved toxins that interfere with specific components of their victim’s core physiological systems, thereby causing biological dysfunction that aids in prey capture, defense against predators, or other
Venomous animals have evolved toxins that interfere with specific components of their victim’s core physiological systems, thereby causing biological dysfunction that aids in prey capture, defense against predators, or other
Autor:
Sébastien Dutertre, Paul F. Alewood, Frank Bosmans, Brianna Sollod Mcfarland, Irina Vetter, Wayne C. Hodgson, Richard J. Lewis, Sandy S. Pineda, Mathilde R. Israel, Bryan G. Fry, Glenn F. King, David Wilson, Kartik Sunagar, Volker Herzig, Eivind A. B. Undheim
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2020, 117 (40), pp.24920-24928. ⟨10.1073/pnas.2004516117⟩
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2020, 117 (40), pp.24920-24928. ⟨10.1073/pnas.2004516117⟩
Proc Natl Acad Sci U S A
International audience; Australian funnel-web spiders are infamous for causing human fatalities, which are induced by venom peptides known as δ-hexatoxins (δ-HXTXs). Humans and other primates did not feature in the prey or predator spectrum during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427abec460f2efd51eeee4565062098b
https://hal.archives-ouvertes.fr/hal-03440284
https://hal.archives-ouvertes.fr/hal-03440284
Autor:
Fabian B. H. Rehm, Jennifer L. Stow, Thomas Durek, Sina Jami, Mathilde R. Israel, Samuel D. Robinson, Edward K. Gilding, Jennifer R. Deuis, Irina Vetter, Peta J. Harvey, Brett Hamilton, David J. Craik, Darren L. Brown, Aaron G. Poth, Kuok Yap, David Andersson
Publikováno v:
Science Advances
Gilding, E K, Jami, S, Duis, J R, Israel, M R, Harvey, P J, Poth, A G, Rehm, F B H, Stow, J L, Robinson, S D, Yap, K, Brown, D L, Hamilton, B R, Andersson, D, Craik, D J, Vetter, I & Durek, T 2020, ' Neurotoxic Peptides from the Venom of the Giant Australian Stinging Tree ', Science Advances, vol. 6, no. 38, eabb8828, pp. 1-9 . https://doi.org/10.1126/sciadv.abb8828
Gilding, E K, Jami, S, Duis, J R, Israel, M R, Harvey, P J, Poth, A G, Rehm, F B H, Stow, J L, Robinson, S D, Yap, K, Brown, D L, Hamilton, B R, Andersson, D, Craik, D J, Vetter, I & Durek, T 2020, ' Neurotoxic Peptides from the Venom of the Giant Australian Stinging Tree ', Science Advances, vol. 6, no. 38, eabb8828, pp. 1-9 . https://doi.org/10.1126/sciadv.abb8828
The pain-inducing components of Australian stinging tree venom are miniproteins that modulate voltage-gated sodium channels.
Stinging trees from Australasia produce remarkably persistent and painful stings upon contact of their stiff epidermal h
Stinging trees from Australasia produce remarkably persistent and painful stings upon contact of their stiff epidermal h