The stability of the myelinating oligodendrocyte transcriptome is regulated by the nuclear lamina

Autor: Mathilde Pruvost, Julia Patzig, Camila Yattah, Ipek Selcen, Marylens Hernandez, Hye-Jin Park, Sarah Moyon, Shibo Liu, Malia S. Morioka, Lindsay Shopland, Osama Al-Dalahmah, Jaroslav Bendl, John F. Fullard, Panos Roussos, James Goldman, Ye He, Jeffrey L. Dupree, Patrizia Casaccia

Publikováno v: Cell Reports, Vol 42, Iss 8, Pp 112848- (2023)

Summary: Oligodendrocytes are specialized cells that insulate and support axons with their myelin membrane, allowing proper brain function. Here, we identify lamin A/C (LMNA/C) as essential for transcriptional and functional stability of myelinating

Externí odkaz: https://doaj.org/article/3976a992f3b945e0894a415faea3fb6e

Oligodendroglial Epigenetics, from Lineage Specification to Activity-Dependent Myelination

Autor: Mathilde Pruvost, Sarah Moyon

Publikováno v: Life, Vol 11, Iss 1, p 62 (2021)

Oligodendroglial cells are the myelinating cells of the central nervous system. While myelination is crucial to axonal activity and conduction, oligodendrocyte progenitor cells and oligodendrocytes have also been shown to be essential for neuronal su

Externí odkaz: https://doaj.org/article/a9c8f02c55a940fc949dcd7f1c28fc7a

Sample Preparation for Metabolic Profiling using MALDI Mass Spectrometry Imaging

Autor: Rinat R. Abzalimov, Ye He, David K Dansu, Yuki X. Chen, Damien Marechal, Patrizia Casaccia, Tiffany Zhong, Tenzin Choetso, Kelly Veerasammy, Mathilde Pruvost, Sami Sauma

Publikováno v: Journal of Visualized Experiments.

Metabolomics, the study to identify and quantify small molecules and metabolites present in an experimental sample, has emerged as an important tool to investigate the biological activities during development and diseases. Metabolomics approaches are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03cabf4c1b2e5cd599c9c17c104f35d9
https://doi.org/10.3791/62008-v

Hyperfibrinolysis increases blood–brain barrier permeability by a plasmin- and bradykinin-dependent mechanism

Autor: Mathilde Pruvost, Joan Montaner, Yannick Hommet, Maxime Gauberti, Antoine Anfray, Yvann Frigout, Cyrille Orset, Denis Vivien, Sara Martinez de Lizarrondo, Isabelle Bardou, Oscar A. Marcos-Contreras, Laurent Lebouvier

Publikováno v: Blood. 128:2423-2434

Hyperfibrinolysis is a systemic condition occurring in various clinical disorders such as trauma, liver cirrhosis, and leukemia. Apart from increased bleeding tendency, the pathophysiological consequences of hyperfibrinolysis remain largely unknown.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12d44038e1728c20237d630fe457ef66
https://doi.org/10.1182/blood-2016-03-705384

tPA promotes ADAMTS-4-induced CSPG degradation, thereby enhancing neuroplasticity following spinal cord injury

Autor: Denis Vivien, Maxime Gauberti, Marcel Mersel, Jari Koistinaho, Véronique Agin, Carine Ali, Hubert Vaudry, Jean-Claude do Rego, Sighild Lemarchant, Mathilde Pruvost, Eric Maubert, Aurélien Briens, François Féron, Didier Petite, Evelyne Emery, Yannick Hommet, Yatma Gueye, Marie Hébert

Publikováno v: Neurobiology of Disease
Neurobiology of Disease, 2014, 66, pp.28-42. ⟨10.1016/j.nbd.2014.02.005⟩
Neurobiology of Disease, Elsevier, 2014, 66, pp.28-42. ⟨10.1016/j.nbd.2014.02.005⟩
Neurobiology of Disease, Vol 66, Iss, Pp 28-42 (2014)

Although tissue plasminogen activator (tPA) is known to promote neuronal remodeling in the CNS, no mechanism of how this plastic function takes place has been reported so far. We provide here in vitro and in vivo demonstrations that this serine prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4b64be1ca1c2e47c47cc26bf7ba1b0
https://amu.hal.science/hal-02283038