Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Mathilde Poussin"'
Autor:
Alba Rodriguez-Garcia, Rachel C. Lynn, Mathilde Poussin, Monika A. Eiva, Lauren C. Shaw, Roddy S. O’Connor, Nicholas G. Minutolo, Victoria Casado-Medrano, Gonzalo Lopez, Takami Matsuyama, Daniel J. Powell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Several strategies have been attempted to target immune suppressive populations in the tumor microenvironment. Here the authors show that folate receptor β-targeted CAR-T cells eliminate immunosuppressive tumor associated macrophages, promoting endo
Externí odkaz:
https://doaj.org/article/ccc6ff85f88e4afdb0a9c7be290f2a3b
Autor:
Jason Manro, Carmine Carpenito, Flora Huang, Mathilde Poussin, Arlene Sereno, Xiufeng Wu, Shanshan Cao, Andrew Glasebrook, Daniel J Powell Jr, Stephen Demarest
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)
Background Bispecific T cell engagers represent the majority of bispecific antibodies (BsAbs) entering the clinic to treat metastatic cancer. The ability to apply these agents safely and efficaciously in the clinic, particularly for solid tumors, has
Externí odkaz:
https://doaj.org/article/8e718885296b40cb8b147fa475c01d77
Autor:
Lauren C. Shaw, Mathilde Poussin, Alba Rodriguez-Garcia, Joshua Eggold, Nicholas G. Minutolo, Jie Wang, Alain H. Rook, Stephen J. Schuster, Daniel J. Powell
Publikováno v:
Blood Advances. 7:1885-1898
Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of lymphoid malignancies associated with poor prognosis due to ineffective treatment options and high rates of relapse. The success of chimeric antigen receptor T-cell (CART) therapy for c
Autor:
Daniel J. Powell, Carl H. June, Raphael Sandaltzopoulos, Degang Song, Alex W. Klattenhoff, Mathilde Poussin, Evripidis Lanitis
PDF file - 1301K, Figure S2. Absence of degranulation by CD19-28z CART cells in response to tumor cells expressing mesothelin or FRa or both. CD19-28z CART cells were cultured with the indicated antigen-negative tumor cells or tumor cells expressing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5b5a93fbb90ebafb11958b17dfcbe9
https://doi.org/10.1158/2326-6066.22537088.v1
https://doi.org/10.1158/2326-6066.22537088.v1
Adoptive transfer of T cells engineered to express chimeric immunoreceptors is an effective strategy to treat hematologic cancers; however, the use of this type of therapy for solid cancers, such as ovarian cancer, remains challenging because a safe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14c3e6f15b0597745b3744a1823fa9dc
https://doi.org/10.1158/2326-6066.c.6548531.v1
https://doi.org/10.1158/2326-6066.c.6548531.v1
The expression of 18S used as a internal control (housekeeper). cDNA was constructed from total RNA isolated from 10e5 cells (cultured at 60-70% confluence). PCR performed using intron-spanning primers. Validation criteria included water blanks, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19223fd29adb63acf5a3b5bd91f864bd
https://doi.org/10.1158/2326-6066.22537712.v1
https://doi.org/10.1158/2326-6066.22537712.v1
Autor:
Daniel J. Powell, Carl H. June, Raphael Sandaltzopoulos, Degang Song, Alex W. Klattenhoff, Mathilde Poussin, Evripidis Lanitis
PDF file - 514K, Figure S4. A1847 (M+/F+) and A1847 (M+/F-) cells exhibit similar in vitro growth rate. 1 x 106 A1847 (M+/F+) and A1847 (M+/F-) cells were seeded on day 0 and their in vitro growth kinetics were monitored by determining viable cells u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1f34996a1f50ed180204f0846dd070
https://doi.org/10.1158/2326-6066.22537082.v1
https://doi.org/10.1158/2326-6066.22537082.v1
Autor:
Daniel J. Powell, Carl H. June, Raphael Sandaltzopoulos, Degang Song, Alex W. Klattenhoff, Mathilde Poussin, Evripidis Lanitis
PDF file - 159K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55803ef47456749d7eae22e1cf8ac31f
https://doi.org/10.1158/2326-6066.22537073.v1
https://doi.org/10.1158/2326-6066.22537073.v1
Autor:
Daniel J. Powell, Carl H. June, Raphael Sandaltzopoulos, Degang Song, Alex W. Klattenhoff, Mathilde Poussin, Evripidis Lanitis
PDF file - 1125K, Figure S1. Correlated scFv and GFP transgene expression following F-28 CAR transduction. T cells were lentivirally transduced to express the costimulatory F-28 CAR and 5 days later were stained for surface scFv using biotinylated pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716bf9d66bc694a4a5187162ba845cd3
https://doi.org/10.1158/2326-6066.22537091.v1
https://doi.org/10.1158/2326-6066.22537091.v1
Autor:
Daniel J. Powell, Carl H. June, Raphael Sandaltzopoulos, Degang Song, Alex W. Klattenhoff, Mathilde Poussin, Evripidis Lanitis
PDF file - 583K, Figure S6. Trans-, but not cis-, signaling CART cells exhibit more limited in vitro activity against cells bearing single antigen. IFN-γ secretion by trans M-z/F-28 CART cells was significantly reduced in response to A1847M+/F- cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::258fe235eb684370b8b1a9ed28fd740d
https://doi.org/10.1158/2326-6066.22537076
https://doi.org/10.1158/2326-6066.22537076