Supplementary Table and Figure Legend from Paired Exome Analysis Reveals Clonal Evolution and Potential Therapeutic Targets in Urothelial Carcinoma

Autor: Lars Dyrskjøt, Torben F. Ørntoft, Jakob Skou Pedersen, Søren Høyer, Jørgen Bjerggaard Jensen, Michael Borre, Jakob Hedegaard, Søren Vang, Palle Villesen, Mathilde Borg Houlberg Thomsen, Karin Birkenkamp-Demtröder, Iver Nordentoft, Philippe Lamy

Legend for Supplementary Tables S1-S6 and Supplementary Figures S1-S19.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60bd67dd5a02a0064ba7a5845f53d97c
https://doi.org/10.1158/0008-5472.22413734

Supplementary Methods and References from Paired Exome Analysis Reveals Clonal Evolution and Potential Therapeutic Targets in Urothelial Carcinoma

Autor: Lars Dyrskjøt, Torben F. Ørntoft, Jakob Skou Pedersen, Søren Høyer, Jørgen Bjerggaard Jensen, Michael Borre, Jakob Hedegaard, Søren Vang, Palle Villesen, Mathilde Borg Houlberg Thomsen, Karin Birkenkamp-Demtröder, Iver Nordentoft, Philippe Lamy

Description of additional methods and procedures used in the study. Also includes Supplementary References.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a148adbb9b7e888808b5a98661b0f11
https://doi.org/10.1158/0008-5472.22413755.v1

Comprehensive multiregional analysis of molecular heterogeneity in bladder cancer

Autor: Lars Dyrskjøt, Christophe K. Mapendano, Torben F. Ørntoft, Iver Nordentoft, Jørgen Bjerggaard Jensen, Søren Høyer, Mathilde Borg Houlberg Thomsen, Philippe Lamy, Søren Vang, Line S. Reinert

Publikováno v: Thomsen, M B H, Nordentoft, I, Lamy, P, Vang, S, Reinert, L, Mapendano, C K, Høyer, S, Ørntoft, T F, Jensen, J B & Dyrskjøt, L 2017, ' Comprehensive multiregional analysis of molecular heterogeneity in bladder cancer ', Scientific Reports, vol. 7, no. 1, pp. 11702 . https://doi.org/10.1038/s41598-017-11291-0
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Scientific Reports

Genetic alterations identified in adjacent normal appearing tissue in bladder cancer patients are indicative of a field disease. Here we assessed normal urothelium transformation and intra-tumour heterogeneity (ITH) in four patients with bladder canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057d98d8b836c8092c06ebe5dbffb8e8
https://doi.org/10.1038/s41598-017-11291-0

Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma

Autor: Lars Dyrskjøt, Michael Borre, Karin Mogensen, Torben F. Ørntoft, Roman Nawroth, Gregers G. Hermann, Jørgen Bjerggaard Jensen, Núria Malats, Mattias Höglund, Philippe Lamy, Ewout W. Steyerberg, Sven Wach, Ellen C. Zwarthoff, Tatjana Simic, Kerstin Junker, Jakob Skou Pedersen, Astrid Christine Petersen, Mathilde Borg Houlberg Thomsen, Arndt Hartmann, Ferran Algaba, Karin Birkenkamp-Demtröder, M. Luz Calle, Jakob Hedegaard, Niels Fristrup, Kim E.M. van Kessel, Per-Uno Malmström, Bastian Keck, Cane Tulic, Søren Vang, Iver Nordentoft, Søren Høyer, Willemien Beukers, Francisco X. Real, Robert Stöhr, Tobias Maurer, Anna Katharina Seitz, Benedicte Parm Ulhøi, Marcus Horstmann, Ulrika Segersten, Mirari Marquez, Thomas Reinert, Morten Muhlig Nielsen, Niels Harving, Mattias Aine

Publikováno v: Hedegaard, J, Lamy, P, Nordentoft, I, Algaba, F, Høyer, S, Ulhøi, B P, Vang, S, Reinert, T, Hermann, G G, Mogensen, K, Thomsen, M B H, Nielsen, M M, Marquez, M, Segersten, U, Aine, M, Höglund, M, Birkenkamp-Demtröder, K, Fristrup, N, Borre, M, Hartmann, A, Stöhr, R, Wach, S, Keck, B, Seitz, A K, Nawroth, R, Maurer, T, Tulic, C, Simic, T, Junker, K, Horstmann, M, Harving, N, Petersen, A C, Calle, M L, Steyerberg, E W, Beukers, W, van Kessel, K E M, Jensen, J B, Pedersen, J S, Malmström, P-U, Malats, N, Real, F X, Zwarthoff, E C, Ørntoft, T F & Dyrskjøt, L 2016, ' Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma ', Cancer Cell, vol. 30, no. 1, pp. 27-42 . https://doi.org/10.1016/j.ccell.2016.05.004
Cancer Cell, 30(1), 27-42. Cell Press
Hedegaard, J, Lamy, P, Nordentoft, I, Algaba, F, Høyer, S, Ulhøi, B P, Vang, S, Reinert, T, Hermann, G G, Mogensen, K, Thomsen, M B H, Nielsen, M M, Marquez, M, Segersten, U, Aine, M, Höglund, M, Birkenkamp-Demtröder, K, Fristrup, N, Borre, M, Hartmann, A, Stöhr, R, Wach, S, Keck, B, Seitz, A K, Nawroth, R, Maurer, T, Tulic, C, Simic, T, Junker, K, Horstmann, M, Harving, N, Petersen, A C, Calle, M L, Steyerberg, E W, Beukers, W, van Kessel, K E M, Jensen, J B, Pedersen, J S, Malmström, P-U, Malats, N, Real, F X, Zwarthoff, E C, Ørntoft, T F & Dyrskjøt, L 2016, ' Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma ', Cancer Cell, vol. 30, no. 1, pp. 27–42 . https://doi.org/10.1016/j.ccell.2016.05.004
CANCER CELL
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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Non-muscle-invasive bladder cancer (NMIBC) is a heterogeneous disease with widely different outcomes. We performed a comprehensive transcriptional analysis of 460 early-stage urothelial carcinomas and showed that NMIBC can be subgrouped into three ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::982a3ccc750a98100bed57ceb2863b2f
https://vbn.aau.dk/da/publications/2c9845c8-f9a6-44e7-aff7-cb4e3d7e9220

Abstract 3948: Comprehensive characterization of genomic and transcriptomic heterogeneity in advanced bladder cancer by multiregional analysis

Autor: Lars Dyrskjøt, Torben F. Ørntoft, Line S. Reinert, Philippe Lamy, Jørgen Bjerggaard Jensen, Søren Høyer, Mathilde Borg Houlberg Thomsen, Søren Vang, Iver Nordentoft

Publikováno v: Cancer Research. 77:3948-3948

Background: Bladder cancer is a highly heterogeneous disease - both clinically, and at the genomic and the transcriptomic levels. Despite complete tumor resections, recurrent tumors share a high number of mutations with the initial/earlier tumors, in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aab776d393e1b7ecf682edc01258eefa
https://doi.org/10.1158/1538-7445.am2017-3948