Iodine containing porous organosilica nanoparticles trigger tumor spheroids destruction upon monochromatic X-ray irradiation: DNA breaks and K-edge energy X-ray

Autor: Yuya Higashi, Kotaro Matsumoto, Hiroyuki Saitoh, Ayumi Shiro, Yue Ma, Mathilde Laird, Shanmugavel Chinnathambi, Albane Birault, Tan Le Hoang Doan, Ryo Yasuda, Toshiki Tajima, Tetsuya Kawachi, Fuyuhiko Tamanoi

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract X-ray irradiation of high Z elements causes photoelectric effects that include the release of Auger electrons that can induce localized DNA breaks. We have previously established a tumor spheroid-based assay that used gadolinium containing m

Externí odkaz: https://doaj.org/article/0774ae605b3341aab8bffe43ed7857d6

Organosilica nanoparticles containing sodium borocaptate (BSH) provide new prospects for boron neutron capture therapy (BNCT): efficient cellular uptake and enhanced BNCT efficacy

Autor: Mathilde Laird, Kotaro Matsumoto, Yuya Higashi, Aoi Komatsu, Art Raitano, Kendall Morrison, Minoru Suzuki, Fuyuhiko Tamanoi

Publikováno v: Nanoscale Advances. 5:2537-2546

BSH-containing mesoporous organosilica nanoparticles improve the boron uptake into cells and enhance BNCT efficacy.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3451966268a331297d5ab54ec6bb0608
https://doi.org/10.1039/d2na00839d

Large Polyhedral Oligomeric Silsesquioxane Cages: The Isolation of Functionalized POSS with an Unprecedented Si 18 O 27 Core

Autor: Naseem A. Ramsahye, Mathilde Laird, Masafumi Unno, John R. Bartlett, Michel Wong Chi Man, Carole Carcel, Cédric Totée, Niklas Herrmann

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2021, 60 (6), pp.3022-3027. ⟨10.1002/anie.202010458⟩

International audience; The synthesis of organo-functionalized polyhedral oligomeric silsesquioxanes (POSS, (R-SiO1.5)n, Tn) is an area of significant activity. To date, T14 is the largest such cage synthesized and isolated as a single isomer. Herein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c067786cde1138a4c3525fae56418d4
https://doi.org/10.1002/ange.202010458

Construction of Boronophenylalanine-Loaded Biodegradable Periodic Mesoporous Organosilica Nanoparticles for BNCT Cancer Therapy

Autor: Minoru Suzuki, Kotaro Matsumoto, Aoi Komatsu, Ngoc Xuan Dat Mai, Tan Le Hoang Doan, Albane Birault, Shanmugavel Chinnathambi, Fuyuhiko Tamanoi, Kendall Morrison, Arthur Raitano, Takushi Takata, Mathilde Laird

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 5
International Journal of Molecular Sciences, Vol 22, Iss 2251, p 2251 (2021)

Biodegradable periodic mesoporous organosilica (BPMO) has recently emerged as a promising type of mesoporous silica-based nanoparticle for biomedical applications. Like mesoporous silica nanoparticles (MSN), BPMO possesses a large surface area where

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0110ad31f38b70a0190fc7f3302fbd28

Iodine containing porous organosilica nanoparticles trigger tumor spheroids destruction upon monochromatic X-ray irradiation: DNA breaks and K-edge energy X-ray

Autor: Mathilde Laird, Fuyuhiko Tamanoi, Hiroyuki Saitoh, Tan Le Hoang Doan, Toshiki Tajima, Kotaro Matsumoto, Yuya Higashi, Ryo Yasuda, Ayumi Shiro, Tetsuya Kawachi, Yue Ma, Albane Birault, Shanmugavel Chinnathambi

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

X-ray irradiation of high Z elements causes photoelectric effects that include the release of Auger electrons that can induce localized DNA breaks. We have previously established a tumor spheroid-based assay that used gadolinium containing mesoporous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aaa4bbcd18872c1b44c0f7adcc96405
http://hdl.handle.net/2433/264444