Hyperglycemia triggers RyR2-dependent alterations of mitochondrial calcium homeostasis in response to cardiac ischemia-reperfusion: Key role of DRP1 activation

Autor: Mathilde Dubois, Doria Boulghobra, Gilles Rochebloine, Florian Pallot, Marc Yehya, Isabelle Bornard, Sandrine Gayrard, Florence Coste, Guillaume Walther, Gregory Meyer, Jean-Charles Gaillard, Jean Armengaud, Béatrice Alpha-Bazin, Cyril Reboul

Publikováno v: Redox Biology, Vol 70, Iss , Pp 103044- (2024)

Hyperglycemia increases the heart sensitivity to ischemia-reperfusion (IR), but the underlying cellular mechanisms remain unclear. Mitochondrial dynamics (the processes that govern mitochondrial morphology and their interactions with other organelles

Externí odkaz: https://doaj.org/article/2ee5d3684a4543158afbdc835c41bcfb

Impact of exercise training on mitochondrial dynamics during ischemia-reperfusion

Autor: Doria Boulghobra, Mathilde Dubois, Florian Pallot, Isabelle Bornard, Florence Coste, Guillaume Walther, Grégory Meyer, Cyril Reboul

Publikováno v: Archives of Cardiovascular Diseases Supplements. 14:170-171

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04a5b88051c26f9e3192ce4a27e3a938
https://doi.org/10.1016/j.acvdsp.2022.04.036

Digestive n‐6 Lipid Oxidation, a Key Trigger of Vascular Dysfunction and Atherosclerosis in the Western Diet: Protective Effects of Apple Polyphenols

Autor: S. Risdon, Claire Dufour, Gaetan Bolea, Mathilde Dubois, Grégory Meyer, Bernard Geny, Clothilde Philouze, Cyril Reboul, Christian Ginies, Claire Arnaud, Anne-Laure Charles, Anaïs Humberclaude

Publikováno v: Molecular Nutrition and Food Research
Molecular Nutrition and Food Research, Wiley-VCH Verlag, 2021, 65 (6), pp.2000487. ⟨10.1002/mnfr.202000487⟩
Molecular Nutrition and Food Research, Wiley-VCH Verlag, 2021, pp.2000487. ⟨10.1002/mnfr.202000487⟩

International audience; Scope: A main risk factor of atherosclerosis is a Western diet (WD) rich in n-6 polyunsaturated fatty acids (PUFAs) sensitive to oxidation. Their oxidation can be initiated by heme iron of red meat leading to the formation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d03dffad24fa72a92174c321743430
https://hal.archives-ouvertes.fr/hal-03363870

Reactive oxygen species as therapeutic targets in pulmonary hypertension

Autor: Véronique Freund-Michel, Christelle Guibert, Mathilde Dubois, Arnaud Courtois, Roger Marthan, Jean-Pierre Savineau, Bernard Muller

Publikováno v: Therapeutic Advances in Respiratory Disease, Vol 7 (2013)

Pulmonary hypertension (PH) is characterized by a progressive elevation of pulmonary arterial pressure due to alterations of both pulmonary vascular structure and function. This disease is rare but life-threatening, leading to the development of righ

Externí odkaz: https://doaj.org/article/6f29c672da004472ae96316c3e4485eb

Restoring Endothelial Function by Targeting Desert Hedgehog Downstream of Klf2 Improves Critical Limb Ischemia in Adults

Autor: Marie-Ange Renault, Caroline Caradu, Candice Chapouly, Pierre-Louis Hollier, Sarah Guimbal, Alessandra Bura-Rivière, Thierry Couffinhal, Mathilde Dubois, Eric Ducasse, Alain-Pierre Gadeau

Publikováno v: Circulation Research
Circulation Research, American Heart Association, 2018, 123 (9), pp.1053-1065. ⟨10.1161/CIRCRESAHA.118.313177⟩
Circulation Research, 2018, 123 (9), pp.1053-1065. ⟨10.1161/CIRCRESAHA.118.313177⟩

Rationale: Klf (kruppel-like factor) 2 is critical to establish and maintain endothelial integrity. Objective: Therefore, determining upstream and downstream mediators of Klf2 would lead to alternative therapeutic targets in cardiovascular disease ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a772863bb8261c9747d04f7778ce3d
https://doi.org/10.1161/circresaha.118.313177