Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mathieu Paquette"'
Autor:
Mathieu Paquette, Ming Yan, Josué M. J. Ramírez-Reyes, Leeanna El-Houjeiri, Marco Biondini, Catherine R. Dufour, Hyeonju Jeong, Alain Pacis, Vincent Giguère, Jennifer L. Estall, Peter M. Siegel, Étienne Audet-Walsh, Arnim Pause
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Non-alcoholic fatty liver disease (NAFLD) is the most frequent liver disease worldwide and can progress to non-alcoholic steatohepatitis (NASH), which is characterized by triglyceride accumulation, inflammation, and fibrosis. No pharmacologi
Externí odkaz:
https://doaj.org/article/1475e426b13d4372960b3695a52f08dd
Autor:
Leeanna El-Houjeiri, Elite Possik, Tarika Vijayaraghavan, Mathieu Paquette, José A. Martina, Jalal M. Kazan, Eric H. Ma, Russell Jones, Paola Blanchette, Rosa Puertollano, Arnim Pause
Publikováno v:
Cell Reports, Vol 26, Iss 13, Pp 3613-3628.e6 (2019)
Summary: TFEB and TFE3 are transcriptional regulators of the innate immune response, but the mechanisms regulating their activation upon pathogen infection are poorly elucidated. Using C. elegans and mammalian models, we report that the master metabo
Externí odkaz:
https://doaj.org/article/246d937dce1a41f48fa99b90e869b2e7
Autor:
Josué M. J. Ramírez-Reyes, Ming Yan, Jennifer L. Estall, Catherine R. Dufour, Arnim Pause, Alain Pacis, Étienne Audet-Walsh, Hyeonju Jeong, Mathieu Paquette, Vincent Giguère, Leeanna El-Houjeiri, Marco Biondini, Peter M. Siegel
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
Non-alcoholic fatty liver disease (NAFLD) is the most frequent liver disease worldwide and can progress to non-alcoholic steatohepatitis (NASH), which is characterized by triglyceride accumulation, inflammation, and fibrosis. No pharmacological agent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd6e21648044a6d82f5fd41abef3598
https://doaj.org/article/1475e426b13d4372960b3695a52f08dd
https://doaj.org/article/1475e426b13d4372960b3695a52f08dd
Autor:
Pietri Puustinen, Kurt Dejgaard, Mathieu Paquette, Paola Blanchette, Hyeonju Jeong, Linda C. Zirden, Peter M. Siegel, Arnim Pause, Leeanna El-Houjeiri
Publikováno v:
Autophagy
Increased macroautophagy/autophagy and lysosomal activity promote tumor growth, survival and chemo-resistance. During acute starvation, autophagy is rapidly engaged by AMPK (AMP-activated protein kinase) activation and MTOR (mechanistic target of rap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35bf0ee53dca713e1c9753fd8a9d6360
https://doi.org/10.1080/15548627.2021.1898748
https://doi.org/10.1080/15548627.2021.1898748
Autor:
Kurt Dejgaard, Linda C. Zirden, Paola Blanchette, Pietri Puustinen, Mathieu Paquette, Arnim Pause, Peter M. Siegel, Hyeonju Jeong, Leeanna El-Houjeiri
Increased autophagy and lysosomal activity promote tumor growth, survival and chemo-resistance. During acute starvation, autophagy is rapidly engaged by AMPK activation and mTORC1 inhibition to maintain energy homeostasis and cell survival. TFEB and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94f123ed0e3c0d0bc64bad8bc0f3a05b
https://doi.org/10.1101/2021.01.27.428292
https://doi.org/10.1101/2021.01.27.428292
Autor:
Mathieu Paquette, Arnim Pause, Marco Biondini, Helen Kuasne, Morag Park, Leeanna El-Houjeiri, Alain Pacis, Peter M. Siegel
Publikováno v:
J Clin Invest
Growing tumors exist in metabolically compromised environments that require activation of multiple pathways to scavenge nutrients to support accelerated rates of growth. The folliculin (FLCN) tumor suppressor complex (FLCN, FNIP1, FNIP2) is implicate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::536b645632ec7ad8b0221f78c8254ff3
https://pubmed.ncbi.nlm.nih.gov/34779410
https://pubmed.ncbi.nlm.nih.gov/34779410
Autor:
Marco Biondini, Mathieu Paquette, Leeanna El-Houjeiri, Jennifer L. Estall, Ming Yan, Alain Pacis, Hyeonju Jeong, Arnim Pause, Peter M. Siegel, Josué M. J. Ramírez-Reyes
Non-alcoholic steatohepatitis (NASH) represents a major economic burden and is characterized by triglyceride accumulation, inflammation, and fibrosis. No pharmacological agents are currently approved to treat this condition. Emerging data suggests an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f064ee3c0d2828eb8fd2abae6a3f006
https://doi.org/10.1101/2020.09.10.291617
https://doi.org/10.1101/2020.09.10.291617
Autor:
Elite Possik, Eric H. Ma, Mathieu Paquette, Russell G. Jones, Jose A. Martina, Arnim Pause, Paola Blanchette, Tarika Vijayaraghavan, Rosa Puertollano, Leeanna El-Houjeiri, Jalal M. Kazan
Publikováno v:
Cell Rep
Cell Reports, Vol 26, Iss 13, Pp 3613-3628.e6 (2019)
Cell Reports, Vol 26, Iss 13, Pp 3613-3628.e6 (2019)
Summary: TFEB and TFE3 are transcriptional regulators of the innate immune response, but the mechanisms regulating their activation upon pathogen infection are poorly elucidated. Using C. elegans and mammalian models, we report that the master metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c8adceda6490af340ba5877ce729f0
https://doi.org/10.1101/463430
https://doi.org/10.1101/463430
Publikováno v:
Cancers, Vol 10, Iss 1, p 18 (2018)
Cancers
Cancers
TOR (target of rapamycin), an evolutionarily-conserved serine/threonine kinase, acts as a central regulator of cell growth, proliferation and survival in response to nutritional status, growth factor, and stress signals. It plays a crucial role in co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee8ffbc0494b605ea8ff46f5292095a
http://www.mdpi.com/2072-6694/10/1/18
http://www.mdpi.com/2072-6694/10/1/18
Autor:
Sylvain Pelletier-Bergeron, Yves Bergeron, Mathieu Paquette, Martin P. Girardin, Sylvie Gauthier, Aurélie Terrier
Publikováno v:
Forests; Volume 8; Issue 1; Pages: 9
Forests, Vol 8, Iss 1, p 9 (2016)
Forests, Vol 8, Iss 1, p 9 (2016)
Old-growth forests play a decisive role in preserving biodiversity and ecological functions. In an environment frequently disturbed by fire, the importance of old-growth forests as both a carbon stock as well as a source of emissions when burnt is no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a2368cd20cf2ca7c7db8461aeb62d93