Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Mathieu Metifiot"'
Autor:
Ferdinand Emaniel Brel Got, Patricia Recordon-Pinson, Ghislain Loubano-Voumbi, Dagene Ebourombi, Marie-Lise Blondot, Mathieu Metifiot, Gontran Ondzotto, Marie-Line Andreola
Publikováno v:
Microorganisms, Vol 9, Iss 11, p 2355 (2021)
Background: HIV infects around one hundred thousand patients in the Republic of the Congo. Approximately 25% of them receive an antiretroviral treatment; current first-line regimens include two NRTIs and one NNRTI, reverse transcriptase inhibitors. R
Externí odkaz:
https://doaj.org/article/d182430eeec342d79337e611664cf62a
Autor:
Cindy Aknin, Elena A. Smith, Christophe Marchand, Marie-Line Andreola, Yves Pommier, Mathieu Metifiot
Publikováno v:
Molecules, Vol 24, Iss 20, p 3675 (2019)
Currently, an increasing number of drugs are becoming available to clinics for the treatment of HIV infection. Even if this targeted therapy is highly effective at suppressing viral replication, caregivers are facing growing therapeutic failures in p
Externí odkaz:
https://doaj.org/article/82f930b645aa45f4913e419ef19e2fd8
Autor:
Chloé Torres, Asja Garling, Saïd Taouji, Christina Calmels, Marie-Line Andreola, Mathieu Métifiot
Publikováno v:
Molecules, Vol 26, Iss 17, p 5423 (2021)
Multiple viral targets are now available in the clinic to fight HIV infection. Even if this targeted therapy is highly effective at suppressing viral replication, caregivers are facing growing therapeutic failures in patients due to resistance, with
Externí odkaz:
https://doaj.org/article/ee205c82514f4ab9869b13e2b16737d7
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Mosquito- and tick-borne pathogens including Chikungunya, Dengue, Japanese encephalitis, West Nile, Yellow fever and Zika virus, represent a new economic and public health challenge. In the absence of effective vaccines and specific therapie
Externí odkaz:
https://doaj.org/article/5d7e140debe44068a932d7d7642b5a5f
Autor:
Xue Zhi Zhao, Mathieu Métifiot, Evgeny Kiselev, Jacques J. Kessl, Kasthuraiah Maddali, Christophe Marchand, Mamuka Kvaratskhelia, Yves Pommier, Terrence R. Burke
Publikováno v:
Molecules, Vol 23, Iss 8, p 1858 (2018)
HIV-1 integrase (IN) inhibitors represent a new class of highly effective anti-AIDS therapeutics. Current FDA-approved IN strand transfer inhibitors (INSTIs) share a common mechanism of action that involves chelation of catalytic divalent metal ions.
Externí odkaz:
https://doaj.org/article/4c907d36f6b14c509e53863d153aad7a
Publikováno v:
Viruses, Vol 2, Iss 7, Pp 1347-1366 (2010)
Integrase (IN) is a clinically validated target for the treatment of human immunodeficiency virus infections and raltegravir exhibits remarkable clinical activity. The next most advanced IN inhibitor is elvitegravir. However, mutant viruses lead to t
Externí odkaz:
https://doaj.org/article/47083e6679e744a6809e556ddb5f9937