The spindle assembly checkpoint and the spatial activation of Polo kinase determine the duration of cell division and prevent tumor formation.

Autor: Emmanuel Gallaud, Laurent Richard-Parpaillon, Laetitia Bataillé, Aude Pascal, Mathieu Métivier, Vincent Archambault, Régis Giet

Publikováno v: PLoS Genetics, Vol 18, Iss 4, p e1010145 (2022)

The maintenance of a restricted pool of asymmetrically dividing stem cells is essential for tissue homeostasis. This process requires the control of mitotic progression that ensures the accurate chromosome segregation. In addition, this event is coup

Externí odkaz: https://doaj.org/article/9c5a51037ed44bd5852710ef4f3b144b

A novel benzodiazepine derivative that suppresses microtubule dynamics and impairs mitotic progression

Autor: Siou Ku, Mathieu Métivier, Emmanuel Gallaud, Vittoria Pirani, Alexandre Thomas, Denis Chrétien, Lorenzo Corsi, Christelle Benaud, Régis Giet, Roberta Ettari

Publikováno v: Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2020, 133 (7), pp.jcs239244. ⟨10.1242/jcs.239244⟩
Journal of Cell Science, 2020, 133 (7), pp.jcs239244. ⟨10.1242/jcs.239244⟩

International audience; A novel 2,3-benzodiazepine-4 derivative, named 1g, has recently been shown to function as an anti-proliferative compound. We now show that it perturbs the formation of a functional mitotic spindle, inducing a spindle assembly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0440ebddcc53d74dfe2ba665936dd3ba
https://hal-univ-rennes1.archives-ouvertes.fr/hal-02543756

Drosophila Tubulin-Specific Chaperone E Recruits Tubulin around Chromatin to Promote Mitotic Spindle Assembly

Autor: Romain Gibeaux, Jean-Philippe Gagné, Laurent Richard-Parpaillon, Emmanuel Gallaud, Régis Giet, Mathieu Métivier, Christelle Benaud, Guy G. Poirier, Alexandre Thomas, Denis Chrétien, Aude Pascal

Publikováno v: Current Biology-CB
Current Biology-CB, Elsevier, 2020, ⟨10.1016/j.cub.2020.11.009⟩
Current Biology-CB, Elsevier, 2021, 31 (4), pp.684-695.e6. ⟨10.1016/j.cub.2020.11.009⟩
Current Biology-CB, 2021, 31 (4), pp.684-695.e6. ⟨10.1016/j.cub.2020.11.009⟩

International audience; Proper assembly of mitotic spindles requires microtubule nucleation not only at the centrosomes but also around chromatin. In this study, we found that the Drosophila tubulin-specific chaperone dTBCE is required for the enrich

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea72db98bb999c46a34233b4cea8da1
https://pubmed.ncbi.nlm.nih.gov/33259793

Mechanisms of Kinesin-1 activation by Ensconsin/MAP7 in vivo

Autor: Emmanuel Gallaud, Kassandra M. Ori-McKenney, Mathieu Métivier, Antoine Guichet, Régis Giet, Brigette Y. Monroy, Aude Pascal, Laurent Richard-Parpaillon, Renaud Caous

Centrosome separation inDrosophilalarval neuroblasts and asymmetric transport of embryonic determinants in oocytes are both microtubule-dependent processes that require Kinesin-1 activation by Ensconsin/microtubule-associated protein 7 (MAP7). Howeve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cccd114a3a77e20b098b9f59e0523b4