Výsledky vyhledávání - "Mathieu Métifiot"

Akademický článek

Targeting the Integrated Stress Response Kinase GCN2 to Modulate Retroviral Integration

Autor: Chloé Torres, Asja Garling, Saïd Taouji, Christina Calmels, Marie-Line Andreola, Mathieu Métifiot

Publikováno v: Molecules, Vol 26, Iss 17, p 5423 (2021)

Multiple viral targets are now available in the clinic to fight HIV infection. Even if this targeted therapy is highly effective at suppressing viral replication, caregivers are facing growing therapeutic failures in patients due to resistance, with

Externí odkaz: https://doaj.org/article/ee205c82514f4ab9869b13e2b16737d7

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Akademický článek

De novo RNA synthesis catalyzed by the Zika Virus RNA polymerase domain

Autor: Christina Calmels, Michel Ventura, Cindy Aknin, Mathieu Métifiot, Marie-Line Andreola

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)

Abstract Mosquito- and tick-borne pathogens including Chikungunya, Dengue, Japanese encephalitis, West Nile, Yellow fever and Zika virus, represent a new economic and public health challenge. In the absence of effective vaccines and specific therapie

Externí odkaz: https://doaj.org/article/5d7e140debe44068a932d7d7642b5a5f

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Template requirements of Zika RNA polymerase during in vitro RNA synthesis from the 3′-end of virus minus-strand RNA

Autor: Christina Calmels, Mathieu Métifiot, Marie-Line Andreola

Publikováno v: Biochimie
Biochimie, 2021, ⟨10.1016/j.biochi.2021.11.003⟩

As ZIKV continues to spread, many “unknowns” remain and research is needed to advance the understanding of this important pathogen. Viral RNA dependent-RNA polymerases (RdRp) are validated targets for inhibitors of the replication of several viru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae6e3d81f29d83c71d3e02cf063bc9a5
https://doi.org/10.1016/j.biochi.2021.11.003

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Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase

Autor: Nicole Grandi, Enzo Tramontano, Francesca Esposito, Davide Ialongo, Alessandro De Leo, Giorgio Amendola, Daniela De Vita, Antonella Messore, Valentina Noemi Madia, Marie-Line Andreola, Ettore Novellino, Mathieu Métifiot, Sandro Cosconati, Roberta Costi, Angela Corona, Roberto Di Santo, Valeria Tudino, Francesco Saccoliti, Luigi Scipione

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (12), pp.8579-8598. ⟨10.1021/acs.jmedchem.1c00535⟩

Novel anti-HIV agents are still needed to overcome resistance issues, in particular inhibitors acting against novel viral targets. The ribonuclease H (RNase H) function of the reverse transcriptase (RT) represents a validated and promising target, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7119c7f6ddd81a9fee5dea8606a4e7
https://doi.org/10.1021/acs.jmedchem.1c00535

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Bronchial epithelia from adults and children: SARS-CoV-2 spread via syncytia formation and type III interferon infectivity restriction

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2022, 119 (28), ⟨10.1073/pnas.2202370119⟩

International audience; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections initiate in the bronchi of the upper respiratory tract and are able to disseminate to the lower respiratory tract, where infections can cause an acute res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0d2eef99823f2ac361a27dc432c3a3
https://doi.org/10.1073/pnas.2202370119

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Akademický článek

HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence

Autor: Xue Zhi Zhao, Mathieu Métifiot, Evgeny Kiselev, Jacques J. Kessl, Kasthuraiah Maddali, Christophe Marchand, Mamuka Kvaratskhelia, Yves Pommier, Terrence R. Burke

Publikováno v: Molecules, Vol 23, Iss 8, p 1858 (2018)

HIV-1 integrase (IN) inhibitors represent a new class of highly effective anti-AIDS therapeutics. Current FDA-approved IN strand transfer inhibitors (INSTIs) share a common mechanism of action that involves chelation of catalytic divalent metal ions.

Externí odkaz: https://doaj.org/article/4c907d36f6b14c509e53863d153aad7a

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Akademický článek

Resistance to Integrase Inhibitors

Autor: Mathieu Métifiot, Christophe Marchand, Kasthuraiah Maddali, Yves Pommier

Publikováno v: Viruses, Vol 2, Iss 7, Pp 1347-1366 (2010)

Integrase (IN) is a clinically validated target for the treatment of human immunodeficiency virus infections and raltegravir exhibits remarkable clinical activity. The next most advanced IN inhibitor is elvitegravir. However, mutant viruses lead to t

Externí odkaz: https://doaj.org/article/47083e6679e744a6809e556ddb5f9937

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Absence of Resistance Mutations in the Integrase Coding Region among ART-Experienced Patients in the Republic of the Congo

Autor: Gontran Ondzotto, Patricia Recordon-Pinson, Marie-Lise Blondot, Ferdinand Emaniel Brel Got, Ghislain Loubano-Voumbi, Dagene Ebourombi, Mathieu Métifiot, Marie-Line Andreola

Publikováno v: Microorganisms; Volume 9; Issue 11; Pages: 2355
Microorganisms
Microorganisms, MDPI, 2021, 9 (11), pp.2355. ⟨10.3390/microorganisms9112355⟩
Microorganisms, Vol 9, Iss 2355, p 2355 (2021)

International audience; Background: HIV infects around one hundred thousand patients in the Republic of the Congo. Approximately 25% of them receive an antiretroviral treatment; current first-line regimens include two NRTIs and one NNRTI, reverse tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb92ca94dc223f0e33166dcb44d5d603

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