Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Mathieu Lesort"'
Autor:
William Lee, Reno C. Reyes, Manoj K. Gottipati, Karon Lewis, Mathieu Lesort, Vladimir Parpura, Michelle Gray
Publikováno v:
Neurobiology of Disease, Vol 58, Iss , Pp 192-199 (2013)
Huntington's disease (HD) causes preferential loss of a subset of neurons in the brain although the huntingtin protein is expressed broadly in various neural cell types, including astrocytes. Glutamate-mediated excitotoxicity is thought to cause sele
Externí odkaz:
https://doaj.org/article/672487daeeb5416586bd6ddd5b8f0bb6
Publikováno v:
Neurobiology of Disease, Vol 41, Iss 1, Pp 11-22 (2011)
The presence of aggregates of abnormally expanded polyglutamine (polyQ)-containing proteins are a pathological hallmark of a number of neurodegenerative diseases including Huntington's disease (HD) and spinocerebellar ataxia-3 (SCA3). Previous studie
Externí odkaz:
https://doaj.org/article/eabcf0f9b9664eb9a5c14b6b87e5efff
Autor:
Wanjoo Chun, Mathieu Lesort, Janusz Tucholski, Peter W. Faber, Marcy E. MacDonald, Christopher A. Ross, Gail V.W. Johnson
Publikováno v:
Neurobiology of Disease, Vol 8, Iss 3, Pp 391-404 (2001)
The cause of Huntington's disease (HD) is a pathological expansion of the polyglutamine domain within the N-terminal region of huntingtin. Neuronal intranuclear inclusions and cytoplasmic aggregates composed of the mutant huntingtin within certain ne
Externí odkaz:
https://doaj.org/article/31ba455244b5418a870247d3fda8b00b
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21720 (2011)
Disruption of 14-3-3 function by alpha-synuclein has been implicated in Parkinson's disease. As 14-3-3s are important regulators of cell death pathways, disruption of 14-3-3s could result in the release of pro-apoptotic factors, such as Bax. We have
Externí odkaz:
https://doaj.org/article/888dc704a4db46e7b288699e2f41babf
Autor:
Claudia R. Oliva, Shannon M. Bailey, Adrienne L. King, Angela M. Betancourt, Zhengkuan Mao, Mathieu Lesort, Telisha M. Swain, David R. Crowe, Corrine E. Griguer, Uduak S. Udoh
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 306:G265-G277
Chronic ethanol consumption increases sensitivity of the mitochondrial permeability transition (MPT) pore induction in liver. Ca2+promotes MPT pore opening, and genetic ablation of cyclophilin D (CypD) increases the Ca2+threshold for the MPT. We used
Publikováno v:
Experimental Neurology. 240:96-102
Huntington Disease (HD) is an autosomal dominant neurological disorder characterized by motor, psychiatric and cognitive disturbances. Recent evidence indicates that the viability and function of cerebellar Purkinje cells (PCs) are compromised in an
Autor:
Andrew Kneynsberg, Janusz Tucholski, Thomas van Groen, Giselle Perry, Mathieu Lesort, Ashish Kumar, Peter J. Detloff
Publikováno v:
Experimental Neurology. 237:78-89
Huntington's disease (HD) is a devastating autosomal-dominant neurodegenerative disorder initiated by an abnormally expanded polyglutamine in the huntingtin protein. Determining the contribution of specific factors to the pathogenesis of HD should pr
Autor:
Thomas van Groen, Jennifer Zhang, Michael R. Crowley, Inga Kadish, Mathieu Lesort, Peter J. Detloff, Sara J. Tallaksen-Greene, A. Jennifer Morton, Ashish Kumar, Roger L. Albin, David K. Crossman
Identifying molecular drivers of pathology provides potential therapeutic targets. Differentiating between drivers and coincidental molecular alterations presents a major challenge. Variation unrelated to pathology further complicates transcriptomic,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be6a08082a4314e6ae3ff027254c035
https://www.repository.cam.ac.uk/handle/1810/254593
https://www.repository.cam.ac.uk/handle/1810/254593
Publikováno v:
Neurobiology of Disease, Vol 41, Iss 1, Pp 11-22 (2011)
The presence of aggregates of abnormally expanded polyglutamine (polyQ)-containing proteins are a pathological hallmark of a number of neurodegenerative diseases including Huntington's disease (HD) and spinocerebellar ataxia-3 (SCA3). Previous studie
Publikováno v:
Cell Calcium. 49:23-34
Immunophilins are receptors for immunosuppressive drugs such as the macrolides cyclosporin A (CsA) and FK506; correspondingly these immunophilins are referred to as cyclophilins and FK506-binding proteins (FKBPs). In particular, CsA targets cyclophil